FLHA_BORBU
ID FLHA_BORBU Reviewed; 697 AA.
AC Q44909; Q44759;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 118.
DE RecName: Full=Flagellar biosynthesis protein FlhA;
GN Name=flhA; OrderedLocusNames=BB_0271;
OS Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)
OS (Borrelia burgdorferi).
OC Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX NCBI_TaxID=224326;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RA Dunn J.J., Butler-Loffredo L., Kieleczawa J., Medalle J., Luft B.J.;
RL Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=212;
RA Ge Y., Charon N.W.;
RL Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX PubMed=9403685; DOI=10.1038/37551;
RA Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L.,
RA Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L.,
RA Peterson J.D., Kerlavage A.R., Quackenbush J., Salzberg S.L., Hanson M.,
RA van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F.,
RA Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C.,
RA Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B.,
RA Smith H.O., Venter J.C.;
RT "Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.";
RL Nature 390:580-586(1997).
CC -!- FUNCTION: Required for formation of the rod structure of the flagellar
CC apparatus. Together with FliI and FliH, may constitute the export
CC apparatus of flagellin (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC pore) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA85595.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U43739; AAA85595.1; ALT_INIT; Genomic_DNA.
DR EMBL; L75945; AAB58972.1; -; Genomic_DNA.
DR EMBL; AE000783; AAC66677.1; -; Genomic_DNA.
DR PIR; G70133; G70133.
DR RefSeq; NP_212405.1; NC_001318.1.
DR RefSeq; WP_010889723.1; NC_001318.1.
DR AlphaFoldDB; Q44909; -.
DR SMR; Q44909; -.
DR STRING; 224326.BB_0271; -.
DR PRIDE; Q44909; -.
DR EnsemblBacteria; AAC66677; AAC66677; BB_0271.
DR GeneID; 56567702; -.
DR KEGG; bbu:BB_0271; -.
DR PATRIC; fig|224326.49.peg.670; -.
DR HOGENOM; CLU_015346_3_0_12; -.
DR OMA; MAINPGQ; -.
DR Proteomes; UP000001807; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 1.10.8.540; -; 1.
DR Gene3D; 3.40.30.60; -; 1.
DR Gene3D; 3.40.50.12790; -; 1.
DR InterPro; IPR042194; FHIPEP_1.
DR InterPro; IPR042193; FHIPEP_3.
DR InterPro; IPR042196; FHIPEP_4.
DR InterPro; IPR025505; FHIPEP_CS.
DR InterPro; IPR006301; FlhA.
DR InterPro; IPR001712; T3SS_FHIPEP.
DR PANTHER; PTHR30161; PTHR30161; 1.
DR Pfam; PF00771; FHIPEP; 1.
DR PIRSF; PIRSF005419; FlhA; 1.
DR PRINTS; PR00949; TYPE3IMAPROT.
DR TIGRFAMs; TIGR01398; FlhA; 1.
DR PROSITE; PS00994; FHIPEP; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis; Bacterial flagellum protein export;
KW Cell membrane; Membrane; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..697
FT /note="Flagellar biosynthesis protein FlhA"
FT /id="PRO_0000190011"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 683..685
FT /note="QNI -> PKY (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 697 AA; 76969 MW; C094B9B04FF36EBD CRC64;
MLDARKNSIL GYLGLNNKSD LIISVGLIFV VAGFILPLPA VILDVLITVN LVISLLIILI
VLYSKRSLDF SVFPTLLLVM TIFGLVLNIS STRLILTKGI NFDGQMIRTF GTFVVGSSGI
QGLVIGFIIF IIIIAVQFIV ITKGATRVAE VAARFALDAL PGKQMAIDSA YSSGNLTEEE
ATRQKNDLQS EVNFYGAMDG ASKFVSGNVK VGFLITLINI LGGLLVGITL QGLNFNEALN
NYVSLTVGDG LVSQLPSLLI STSTGLIVTR SISKNSFGGE IFDQFTNHLG IYWIVSGFLL
FLAFLPGFPT LILMFLSLSI AFLAYSLSGI RQKEEIDKKM KLEEEQASIY SDKDVSPVVP
LDPLALEIGY NLVPIVDDTK TSELLDRIVK IRREIAFEFG IVVPKIRIVD NMRLEPNAYS
FKLRGVEVGR GEIKLGKFLV INVGIDSGID GDLVKDPSFG LPSLWVNDDG RETAEKLGYT
VVDPPSIIAT HMTELIKRHS YEILTRQDVQ NTLDVFKKDY GAIVEEVLKN FSVGEIQRVL
QGLLKEQVSI RNLVTIFETI ADFTSITKDI FFLIEKCRQS VGRQITSGYL DLNSELNVIT
LNPSFEQMII DSRVESNHDL ISSIDPNLKT KFIYELFKIV NEVQAEGFYP VVLSSESSRP
IIKVITSREI PDLVVMSVLE VPQNIKVNVL KTVEVEE
