ID   AKTIP_XENTR             Reviewed;         292 AA.
AC   Q28IA3;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=AKT-interacting protein;
DE   AltName: Full=Fused toes protein homolog;
GN   Name=aktip; Synonyms=fts; ORFNames=TEgg032d16.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula, and Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function to promote vesicle trafficking and/or fusion.
CC       May also regulate apoptosis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. FTS
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00388}.
CC   -!- CAUTION: Lacks the conserved Cys residue necessary for ubiquitin-
CC       conjugating enzyme E2 activity. {ECO:0000305}.
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DR   EMBL; CR760509; CAJ81886.1; -; mRNA.
DR   EMBL; BC166144; AAI66144.1; -; mRNA.
DR   EMBL; BC170870; AAI70870.1; -; mRNA.
DR   EMBL; BC171017; AAI71017.1; -; mRNA.
DR   RefSeq; NP_001017203.1; NM_001017203.3.
DR   AlphaFoldDB; Q28IA3; -.
DR   SMR; Q28IA3; -.
DR   STRING; 8364.ENSXETP00000017728; -.
DR   PaxDb; Q28IA3; -.
DR   DNASU; 549957; -.
DR   GeneID; 549957; -.
DR   KEGG; xtr:549957; -.
DR   CTD; 64400; -.
DR   Xenbase; XB-GENE-5735786; aktip.
DR   eggNOG; KOG0429; Eukaryota.
DR   HOGENOM; CLU_083049_0_0_1; -.
DR   InParanoid; Q28IA3; -.
DR   OMA; QVLKYMQ; -.
DR   OrthoDB; 1226125at2759; -.
DR   TreeFam; TF314386; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0070695; C:FHF complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0061631; F:ubiquitin conjugating enzyme activity; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0045022; P:early endosome to late endosome transport; ISS:UniProtKB.
DR   GO; GO:0007032; P:endosome organization; ISS:UniProtKB.
DR   GO; GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.
DR   GO; GO:0007040; P:lysosome organization; ISS:UniProtKB.
DR   GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.110.10; -; 1.
DR   InterPro; IPR000608; UBQ-conjugat_E2.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   Pfam; PF00179; UQ_con; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
DR   PROSITE; PS50127; UBC_2; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cell membrane; Cytoplasm; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..292
FT                   /note="AKT-interacting protein"
FT                   /id="PRO_0000379024"
FT   DOMAIN          75..223
FT                   /note="UBC core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00388"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          273..292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..42
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   292 AA;  33252 MW;  672149EE83B9794C CRC64;
     MNPFWNMSSA AVRKRSDNDE KIATGDQKIS PPRSSSAKKQ LPSIPKNAVP ITKPISPSPS
     VQPTNGTHAS YGPFYLEYSL LAEFTLVVKQ KLPGVYVQPS YRSALMWFGV IFIRHGLYQD
     GVFKFTVYIP DNYPDGECPR LVFDVPVFHP LVDPVSGELD VKRAFTKWRR NHNHIWQVLM
     YARRIFYKID TTSPLNPEAA VLYEKDVQLF KSKVVDSVKL CNSHLFDQPK IEDPYAIIFS
     PWNPVLHDDA RERMLAQKKS EEQSKGLHVS GLSWVKPGSV LPFSKEENSL QT