FLHA_CAUVC
ID FLHA_CAUVC Reviewed; 700 AA.
AC Q03845;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Flagellar biosynthesis protein FlhA;
GN Name=flhA; Synonyms=flbF; OrderedLocusNames=CC_0910;
OS Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=190650;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 19089 / CB15;
RX PubMed=1938923; DOI=10.1128/jb.173.22.7283-7292.1991;
RA Ramakrishnan G., Zhao J.L., Newton A.;
RT "The cell cycle-regulated flagellar gene flbF of Caulobacter crescentus is
RT homologous to a virulence locus (lcrD) of Yersinia pestis.";
RL J. Bacteriol. 173:7283-7292(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 19089 / CB15;
RX PubMed=1732219; DOI=10.1128/jb.174.3.857-866.1992;
RA Sanders L.A., van Way S., Mullin D.A.;
RT "Characterization of the Caulobacter crescentus flbF promoter and
RT identification of the inferred FlbF product as a homolog of the LcrD
RT protein from a Yersinia enterocolitica virulence plasmid.";
RL J. Bacteriol. 174:857-866(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19089 / CB15;
RX PubMed=11259647; DOI=10.1073/pnas.061029298;
RA Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT "Complete genome sequence of Caulobacter crescentus.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC -!- FUNCTION: Required for formation of the rod structure of the flagellar
CC apparatus. Together with FliI and FliH, may constitute the export
CC apparatus of flagellin (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC pore) family. {ECO:0000305}.
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DR EMBL; M73782; AAA23041.1; -; Genomic_DNA.
DR EMBL; M69228; AAA23040.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AE005673; AAK22894.1; -; Genomic_DNA.
DR PIR; A42599; A42599.
DR RefSeq; NP_419726.1; NC_002696.2.
DR RefSeq; WP_010918794.1; NC_002696.2.
DR AlphaFoldDB; Q03845; -.
DR SMR; Q03845; -.
DR STRING; 190650.CC_0910; -.
DR PRIDE; Q03845; -.
DR EnsemblBacteria; AAK22894; AAK22894; CC_0910.
DR KEGG; ccr:CC_0910; -.
DR PATRIC; fig|190650.5.peg.923; -.
DR eggNOG; COG1298; Bacteria.
DR HOGENOM; CLU_015346_3_0_5; -.
DR OMA; MAINPGQ; -.
DR BioCyc; CAULO:CC0910-MON; -.
DR Proteomes; UP000001816; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 1.10.8.540; -; 1.
DR Gene3D; 3.40.30.60; -; 1.
DR Gene3D; 3.40.50.12790; -; 1.
DR InterPro; IPR042194; FHIPEP_1.
DR InterPro; IPR042193; FHIPEP_3.
DR InterPro; IPR042196; FHIPEP_4.
DR InterPro; IPR025505; FHIPEP_CS.
DR InterPro; IPR006301; FlhA.
DR InterPro; IPR001712; T3SS_FHIPEP.
DR PANTHER; PTHR30161; PTHR30161; 1.
DR Pfam; PF00771; FHIPEP; 1.
DR PIRSF; PIRSF005419; FlhA; 1.
DR PRINTS; PR00949; TYPE3IMAPROT.
DR TIGRFAMs; TIGR01398; FlhA; 1.
DR PROSITE; PS00994; FHIPEP; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis; Bacterial flagellum protein export;
KW Cell inner membrane; Cell membrane; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..700
FT /note="Flagellar biosynthesis protein FlhA"
FT /id="PRO_0000190015"
FT TRANSMEM 27..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..323
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..380
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 700 AA; 74529 MW; 833A13B443AF052E CRC64;
MADAAAPNAS SMPSAKSLLD GLMRGEMGLA LGVVGIIVLL IIPVPAPLLD VLLAISLTGS
VLILMTAILI KKPLEFTSFP TVLLVTTLFR LGLNIASTRL ILSHGQEGTG GAGAVIEAFG
HLMMQGNFVI GVIVFIILIV VNFMVVTKGS GRIAEVAARF TLDSMPGKQM AIDADLSTGL
ISQDEAKIRR KELEQESTFF GAMDGASKFV KGDAIAGLII TAINIIGGII IGVVQHKMPF
GDAASTYTIM TIGDGLVSQI PALIISIAAG MVVSKAGVEG SADKALTTQL AMNPVGLGMV
SASSGIIALI PGMPIFPFAA MALAAGALAY KRVQDAKKPK ALDPADLEAA APSEPEEEPI
SASLAIDDVK IELGYGLLTL INDLDGRKLT DQIRALRKTL ASEYGFVMPP VRILDNMRLA
NQGYAIRIKE MEAGAGEVRL GCLMCMDPRG GQVELPGEHV REPAFGLPAT WIADDLREEA
TFRGYTVVDP ATVLTTHLTE ILKENMADLL SYAEVQKLLK ELPETQKKLV DDLIPGTVTA
TTVQRVLQSL LRERVSIRDL PQILEGVGEA APHTASVTQL VEQVRARLAR QLCWANRGDD
GALPIITLSA DWEQAFAEAL IGPGDDKQLA LPPSRLQDFI RGVRDSFERA ALAGEAPVLL
TSPGVRPYVR SIIERFRGQT VVMSQNEIHP RARLKTVGMV
