ID   FLHA_HELPJ              Reviewed;         733 AA.
AC   Q9ZM40;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Flagellar biosynthesis protein FlhA;
GN   Name=flhA; Synonyms=flbA; OrderedLocusNames=jhp_0383;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- FUNCTION: Involved in the export of flagellum proteins.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC       pore) family. {ECO:0000305}.
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DR   EMBL; AE001439; AAD05964.1; -; Genomic_DNA.
DR   PIR; E71937; E71937.
DR   RefSeq; WP_001262913.1; NC_000921.1.
DR   AlphaFoldDB; Q9ZM40; -.
DR   SMR; Q9ZM40; -.
DR   STRING; 85963.jhp_0383; -.
DR   EnsemblBacteria; AAD05964; AAD05964; jhp_0383.
DR   KEGG; hpj:jhp_0383; -.
DR   eggNOG; COG1298; Bacteria.
DR   OMA; MAINPGQ; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 1.10.8.540; -; 1.
DR   Gene3D; 3.40.30.60; -; 1.
DR   Gene3D; 3.40.50.12790; -; 1.
DR   InterPro; IPR042194; FHIPEP_1.
DR   InterPro; IPR042193; FHIPEP_3.
DR   InterPro; IPR042196; FHIPEP_4.
DR   InterPro; IPR025505; FHIPEP_CS.
DR   InterPro; IPR006301; FlhA.
DR   InterPro; IPR001712; T3SS_FHIPEP.
DR   PANTHER; PTHR30161; PTHR30161; 1.
DR   Pfam; PF00771; FHIPEP; 1.
DR   PIRSF; PIRSF005419; FlhA; 1.
DR   PRINTS; PR00949; TYPE3IMAPROT.
DR   TIGRFAMs; TIGR01398; FlhA; 1.
DR   PROSITE; PS00994; FHIPEP; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum biogenesis; Bacterial flagellum protein export;
KW   Cell membrane; Membrane; Protein transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..733
FT                   /note="Flagellar biosynthesis protein FlhA"
FT                   /id="PRO_0000190019"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          360..381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   733 AA;  80779 MW;  EDB00DF3A2F28F0E CRC64;
     MANERSKLAF KKTFPVFKRF LQSKDLALVV FVIAILAIII VPLPPFVLDF LLTISIALSV
     LIILIGLYID KPTDFSAFPT LLLIVTLYRL ALNVATTRMI LTQGYKGPSA VSDIITAFGE
     FSVSGNYVIG AIIFSILVLV NLLVVTNGST RVTEVRARFA LDAMPGKQMA IDADLNSGLI
     DDKEAKKRRA ALSQEADFYG AMDGASKFVK GDAIASIIIT LINIIGGFLV GVFQRDMSLS
     FSASTFTILT IGDGLVGQIP ALIIATATGI VATRTTQNEE EDFASKLITQ LTNKSKTLVI
     VGANLLLFAT IPGLPTFSLA FVGTLFLFIA WLISREGKDG LLTKLENYLS QKFGLDLSEK
     PHSSKIKPHA PTTKTKTPEE IKREEEQAID EVLKIEFLEL ALGYQLISLA DMKQGGDLLE
     RIRGIRKKIA SDYGFLMPQI RIRDNLQLPP THYEIKLKGI VIGEGMVMPD KFLAMNTGFV
     NREIEGIPTK EPAFGMDALW IDAKNKEEAI IQGYTIIDPS TVIATHTSEL VKKYAEDFIT
     KDEVKSLLER LAKDYPTIVE ESKKIPTGAI RSVLQALLHE KIPIKDMLTI LETITDIAPL
     VQNDVNILTE QVRARLSRVI TNAFKSEDGR LKFLTFSTDS EQFLLNKLRE NGTSKSLLLN
     VGELQKLIEG VSEEAMKVLQ KGIAPVILIV EPNLRKALSN QMEQARIDVV VLSHAELDPN
     SNFEALGTIH INF