FLHA_HELPY
ID FLHA_HELPY Reviewed; 733 AA.
AC O06758; O06759;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 25-MAY-2022, entry version 124.
DE RecName: Full=Flagellar biosynthesis protein FlhA;
GN Name=flhA; Synonyms=flbA; OrderedLocusNames=HP_1041;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=85P;
RA Schmitz A., Josenhans C., Suerbaum S.;
RL Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 93-733.
RC STRAIN=ATCC 49503 / 60190;
RA Fauconnier A., Lage A., Bollen A., Godfroid E.;
RL Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the export of flagellum proteins.
CC -!- INTERACTION:
CC O06758; O25747: HP_1122; NbExp=2; IntAct=EBI-6407872, EBI-527952;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC pore) family. {ECO:0000305}.
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DR EMBL; AE000511; AAD08087.1; -; Genomic_DNA.
DR EMBL; Y13395; CAA73825.1; -; Genomic_DNA.
DR EMBL; Y08762; CAA70007.1; -; Genomic_DNA.
DR PIR; A64650; A64650.
DR RefSeq; NP_207831.1; NC_000915.1.
DR RefSeq; WP_001262893.1; NC_018939.1.
DR PDB; 3MYD; X-ray; 2.40 A; A=373-732.
DR PDBsum; 3MYD; -.
DR AlphaFoldDB; O06758; -.
DR SMR; O06758; -.
DR DIP; DIP-3095N; -.
DR IntAct; O06758; 10.
DR MINT; O06758; -.
DR STRING; 85962.C694_05385; -.
DR PaxDb; O06758; -.
DR EnsemblBacteria; AAD08087; AAD08087; HP_1041.
DR KEGG; hpy:HP_1041; -.
DR PATRIC; fig|85962.47.peg.1120; -.
DR eggNOG; COG1298; Bacteria.
DR OMA; MAINPGQ; -.
DR PhylomeDB; O06758; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IBA:GO_Central.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 1.10.8.540; -; 1.
DR Gene3D; 3.40.30.60; -; 1.
DR Gene3D; 3.40.50.12790; -; 1.
DR InterPro; IPR042194; FHIPEP_1.
DR InterPro; IPR042193; FHIPEP_3.
DR InterPro; IPR042196; FHIPEP_4.
DR InterPro; IPR025505; FHIPEP_CS.
DR InterPro; IPR006301; FlhA.
DR InterPro; IPR001712; T3SS_FHIPEP.
DR PANTHER; PTHR30161; PTHR30161; 1.
DR Pfam; PF00771; FHIPEP; 1.
DR PIRSF; PIRSF005419; FlhA; 1.
DR PRINTS; PR00949; TYPE3IMAPROT.
DR TIGRFAMs; TIGR01398; FlhA; 1.
DR PROSITE; PS00994; FHIPEP; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Bacterial flagellum biogenesis;
KW Bacterial flagellum protein export; Cell membrane; Membrane;
KW Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..733
FT /note="Flagellar biosynthesis protein FlhA"
FT /id="PRO_0000190018"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 360..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 113
FT /note="D -> I (in Ref. 1; CAA73825)"
FT /evidence="ECO:0000305"
FT CONFLICT 267
FT /note="A -> R (in Ref. 1; CAA73825)"
FT /evidence="ECO:0000305"
FT CONFLICT 305..307
FT /note="LLL -> YC (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 309
FT /note="A -> C (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 324
FT /note="T -> A (in Ref. 1; CAA73825)"
FT /evidence="ECO:0000305"
FT CONFLICT 370
FT /note="T -> A (in Ref. 1 and 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 381
FT /note="L -> I (in Ref. 1; CAA73825)"
FT /evidence="ECO:0000305"
FT CONFLICT 407
FT /note="I -> Y (in Ref. 1; CAA73825)"
FT /evidence="ECO:0000305"
FT CONFLICT 670
FT /note="V -> A (in Ref. 1; CAA73825)"
FT /evidence="ECO:0000305"
FT CONFLICT 670
FT /note="V -> G (in Ref. 3; CAA70007)"
FT /evidence="ECO:0000305"
FT CONFLICT 710
FT /note="I -> V (in Ref. 3; CAA70007)"
FT /evidence="ECO:0000305"
FT HELIX 388..393
FT /evidence="ECO:0007829|PDB:3MYD"
FT STRAND 398..402
FT /evidence="ECO:0007829|PDB:3MYD"
FT HELIX 404..409
FT /evidence="ECO:0007829|PDB:3MYD"
FT HELIX 412..414
FT /evidence="ECO:0007829|PDB:3MYD"
FT HELIX 418..423
FT /evidence="ECO:0007829|PDB:3MYD"
FT HELIX 425..433
FT /evidence="ECO:0007829|PDB:3MYD"
FT STRAND 441..444
FT /evidence="ECO:0007829|PDB:3MYD"
FT STRAND 452..457
FT /evidence="ECO:0007829|PDB:3MYD"
FT STRAND 460..466
FT /evidence="ECO:0007829|PDB:3MYD"
FT STRAND 471..475
FT /evidence="ECO:0007829|PDB:3MYD"
FT STRAND 486..490
FT /evidence="ECO:0007829|PDB:3MYD"
FT TURN 492..494
FT /evidence="ECO:0007829|PDB:3MYD"
FT STRAND 497..501
FT /evidence="ECO:0007829|PDB:3MYD"
FT HELIX 503..505
FT /evidence="ECO:0007829|PDB:3MYD"
FT HELIX 506..511
FT /evidence="ECO:0007829|PDB:3MYD"
FT STRAND 515..517
FT /evidence="ECO:0007829|PDB:3MYD"
FT HELIX 519..533
FT /evidence="ECO:0007829|PDB:3MYD"
FT HELIX 535..538
FT /evidence="ECO:0007829|PDB:3MYD"
FT HELIX 541..552
FT /evidence="ECO:0007829|PDB:3MYD"
FT HELIX 556..561
FT /evidence="ECO:0007829|PDB:3MYD"
FT HELIX 562..564
FT /evidence="ECO:0007829|PDB:3MYD"
FT HELIX 567..579
FT /evidence="ECO:0007829|PDB:3MYD"
FT HELIX 587..597
FT /evidence="ECO:0007829|PDB:3MYD"
FT HELIX 598..601
FT /evidence="ECO:0007829|PDB:3MYD"
FT HELIX 605..614
FT /evidence="ECO:0007829|PDB:3MYD"
FT HELIX 617..624
FT /evidence="ECO:0007829|PDB:3MYD"
FT STRAND 629..636
FT /evidence="ECO:0007829|PDB:3MYD"
FT HELIX 638..646
FT /evidence="ECO:0007829|PDB:3MYD"
FT STRAND 648..651
FT /evidence="ECO:0007829|PDB:3MYD"
FT STRAND 654..657
FT /evidence="ECO:0007829|PDB:3MYD"
FT HELIX 661..680
FT /evidence="ECO:0007829|PDB:3MYD"
FT STRAND 685..690
FT /evidence="ECO:0007829|PDB:3MYD"
FT HELIX 692..694
FT /evidence="ECO:0007829|PDB:3MYD"
FT HELIX 695..705
FT /evidence="ECO:0007829|PDB:3MYD"
FT STRAND 709..713
FT /evidence="ECO:0007829|PDB:3MYD"
FT HELIX 714..716
FT /evidence="ECO:0007829|PDB:3MYD"
FT STRAND 721..729
FT /evidence="ECO:0007829|PDB:3MYD"
SQ SEQUENCE 733 AA; 80909 MW; C15B4C9EBB3333C5 CRC64;
MANERSKLAF KKTFPVFKRF LQSKDLALVV FVIAILAIII VPLPPFVLDF LLTISIALSV
LIILIGLYID KPTDFSAFPT LLLIVTLYRL ALNVATTRMI LTQGYKGPSA VSDIITAFGE
FSVSGNYVIG AIIFSILVLV NLLVVTNGST RVTEVRARFA LDAMPGKQMA IDADLNSGLI
DDKEAKKRRA ALSQEADFYG AMDGASKFVK GDAIASIIIT LINIIGGFLV GVFQRDMSLS
FSASTFTILT IGDGLVGQIP ALIIATATGI VATRTTQNEE EDFASKLITQ LTNKSKTLVI
VGAILLLFAT IPGLPTFSLA FVGTLFLFIA WLISREGKDG LLTKLENYLS QKFGLDLSEK
PHSSKIKPHT PTTRAKTQEE LKREEEQAID EVLKIEFLEL ALGYQLISLA DMKQGGDLLE
RIRGIRKKIA SDYGFLMPQI RIRDNLQLPP THYEIKLKGI VIGEGMVMPD KFLAMNTGFV
NKEIEGIPTK EPAFGMDALW IETKNKEEAI IQGYTIIDPS TVIATHTSEL VKKYAEDFIT
KDEVKSLLER LAKDYPTIVE ESKKIPTGAI RSVLQALLHE KIPIKDMLTI LETITDIAPL
VQNDVNILTE QVRARLSRVI TNAFKSEDGR LKFLTFSTDS EQFLLNKLRE NGTSKSLLLN
VGELQKLIEV VSEEAMKVLQ KGIAPVILIV EPNLRKALSN QMEQARIDVI VLSHAELDPN
SNFEALGTIH INF
