FLHA_SALTY
ID FLHA_SALTY Reviewed; 692 AA.
AC P40729;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Flagellar biosynthesis protein FlhA;
GN Name=flhA; OrderedLocusNames=STM1913;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KK1004;
RX PubMed=8002587; DOI=10.1128/jb.176.24.7630-7637.1994;
RA Minamino T., Iino T., Kutsukake K.;
RT "Molecular characterization of the Salmonella typhimurium flhB operon and
RT its protein products.";
RL J. Bacteriol. 176:7630-7637(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Required for formation of the rod structure of the flagellar
CC apparatus. Together with FliI and FliH, may constitute the export
CC apparatus of flagellin.
CC -!- INTERACTION:
CC P40729; P15934: fliH; NbExp=2; IntAct=EBI-6410261, EBI-6410310;
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC pore) family. {ECO:0000305}.
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DR EMBL; D32203; BAA06903.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL20829.1; -; Genomic_DNA.
DR PIR; B55546; B55546.
DR RefSeq; NP_460870.1; NC_003197.2.
DR RefSeq; WP_000002386.1; NC_003197.2.
DR PDB; 3A5I; X-ray; 2.80 A; A/B=328-692.
DR PDB; 6AI0; X-ray; 2.40 A; A/B=328-692.
DR PDB; 6AI1; X-ray; 3.50 A; A/B=328-692.
DR PDB; 6AI2; X-ray; 3.30 A; A/B=328-692.
DR PDB; 6AI3; X-ray; 3.30 A; A/B=328-692.
DR PDB; 6CH1; X-ray; 1.90 A; A=360-692.
DR PDB; 6CH2; X-ray; 2.70 A; A/B/C=360-692.
DR PDB; 6CH3; X-ray; 2.68 A; A=360-690.
DR PDB; 7CTN; X-ray; 2.80 A; A/B=328-692.
DR PDBsum; 3A5I; -.
DR PDBsum; 6AI0; -.
DR PDBsum; 6AI1; -.
DR PDBsum; 6AI2; -.
DR PDBsum; 6AI3; -.
DR PDBsum; 6CH1; -.
DR PDBsum; 6CH2; -.
DR PDBsum; 6CH3; -.
DR PDBsum; 7CTN; -.
DR AlphaFoldDB; P40729; -.
DR SMR; P40729; -.
DR IntAct; P40729; 4.
DR STRING; 99287.STM1913; -.
DR TCDB; 3.A.6.2.1; the type iii (virulence-related) secretory pathway (iiisp) family.
DR PaxDb; P40729; -.
DR PRIDE; P40729; -.
DR EnsemblBacteria; AAL20829; AAL20829; STM1913.
DR GeneID; 1253434; -.
DR KEGG; stm:STM1913; -.
DR PATRIC; fig|99287.12.peg.2029; -.
DR HOGENOM; CLU_015346_3_0_6; -.
DR OMA; MAINPGQ; -.
DR PhylomeDB; P40729; -.
DR BioCyc; SENT99287:STM1913-MON; -.
DR EvolutionaryTrace; P40729; -.
DR PHI-base; PHI:8731; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IBA:GO_Central.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 1.10.8.540; -; 1.
DR Gene3D; 3.40.30.60; -; 1.
DR Gene3D; 3.40.50.12790; -; 1.
DR InterPro; IPR042194; FHIPEP_1.
DR InterPro; IPR042193; FHIPEP_3.
DR InterPro; IPR042196; FHIPEP_4.
DR InterPro; IPR025505; FHIPEP_CS.
DR InterPro; IPR006301; FlhA.
DR InterPro; IPR001712; T3SS_FHIPEP.
DR PANTHER; PTHR30161; PTHR30161; 1.
DR Pfam; PF00771; FHIPEP; 1.
DR PIRSF; PIRSF005419; FlhA; 1.
DR PRINTS; PR00949; TYPE3IMAPROT.
DR TIGRFAMs; TIGR01398; FlhA; 1.
DR PROSITE; PS00994; FHIPEP; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Bacterial flagellum biogenesis;
KW Bacterial flagellum protein export; Cell inner membrane; Cell membrane;
KW Membrane; Protein transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..692
FT /note="Flagellar biosynthesis protein FlhA"
FT /id="PRO_0000190017"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT HELIX 354..356
FT /evidence="ECO:0007829|PDB:3A5I"
FT STRAND 362..367
FT /evidence="ECO:0007829|PDB:6CH1"
FT HELIX 369..371
FT /evidence="ECO:0007829|PDB:6CH1"
FT HELIX 373..375
FT /evidence="ECO:0007829|PDB:6CH1"
FT STRAND 377..379
FT /evidence="ECO:0007829|PDB:6AI0"
FT HELIX 382..398
FT /evidence="ECO:0007829|PDB:6CH1"
FT STRAND 406..409
FT /evidence="ECO:0007829|PDB:6CH1"
FT STRAND 417..422
FT /evidence="ECO:0007829|PDB:6CH1"
FT STRAND 425..431
FT /evidence="ECO:0007829|PDB:6CH1"
FT STRAND 437..440
FT /evidence="ECO:0007829|PDB:6CH1"
FT STRAND 450..455
FT /evidence="ECO:0007829|PDB:6CH1"
FT TURN 457..459
FT /evidence="ECO:0007829|PDB:6CH1"
FT STRAND 462..466
FT /evidence="ECO:0007829|PDB:6CH1"
FT HELIX 468..470
FT /evidence="ECO:0007829|PDB:6CH1"
FT HELIX 471..476
FT /evidence="ECO:0007829|PDB:6CH1"
FT STRAND 480..483
FT /evidence="ECO:0007829|PDB:6CH1"
FT HELIX 484..498
FT /evidence="ECO:0007829|PDB:6CH1"
FT HELIX 500..503
FT /evidence="ECO:0007829|PDB:6CH1"
FT HELIX 506..519
FT /evidence="ECO:0007829|PDB:6CH1"
FT HELIX 521..527
FT /evidence="ECO:0007829|PDB:6CH1"
FT TURN 528..531
FT /evidence="ECO:0007829|PDB:6CH1"
FT HELIX 534..546
FT /evidence="ECO:0007829|PDB:6CH1"
FT HELIX 554..564
FT /evidence="ECO:0007829|PDB:6CH1"
FT TURN 565..567
FT /evidence="ECO:0007829|PDB:6CH1"
FT HELIX 571..581
FT /evidence="ECO:0007829|PDB:6CH1"
FT HELIX 583..590
FT /evidence="ECO:0007829|PDB:6CH1"
FT STRAND 593..595
FT /evidence="ECO:0007829|PDB:6CH1"
FT STRAND 597..602
FT /evidence="ECO:0007829|PDB:6CH1"
FT HELIX 604..614
FT /evidence="ECO:0007829|PDB:6CH1"
FT STRAND 615..617
FT /evidence="ECO:0007829|PDB:6AI0"
FT HELIX 622..642
FT /evidence="ECO:0007829|PDB:6CH1"
FT STRAND 646..650
FT /evidence="ECO:0007829|PDB:6CH1"
FT HELIX 652..654
FT /evidence="ECO:0007829|PDB:6CH1"
FT HELIX 655..663
FT /evidence="ECO:0007829|PDB:6CH1"
FT STRAND 670..673
FT /evidence="ECO:0007829|PDB:6CH1"
FT TURN 674..676
FT /evidence="ECO:0007829|PDB:6CH1"
FT STRAND 679..681
FT /evidence="ECO:0007829|PDB:6CH3"
FT STRAND 683..689
FT /evidence="ECO:0007829|PDB:6CH1"
SQ SEQUENCE 692 AA; 74849 MW; 8E0D65026DE84B47 CRC64;
MANLVAMLRL PSNLKSTQWQ ILAGPILILL ILSMMVLPLP AFILDLLFTF NIALSIMVLL
VAMFTQRTLD FAAFPTILLF TTLLRLALNV ASTRIILMEG HTGAAAAGKV VEAFGHFLVG
GNFAIGIVVF IILVIINFMV ITKGAGRIAE VGARFVLDGM PGKQMAIDAD LNAGLIGEDE
AKKRRSEVTQ EADFYGSMDG ASKFVRGDAI AGILIMVINV VGGLLVGVLQ HGMSIGSAAE
SYTLLTIGDG LVAQIPALVI STAAGVIVTR VSTDQDVGEQ MVGQLFSNPR VMLLAAAVLG
LLGMVPGMPN LVFLLFTAAL LGLAWWLRGR EEKAPEEPQP VKMPENNSVV EATWNDVQLE
DSLGMEVGYR LIPMVDFQQD GELLGRIRSI RKKFAQDMGF LPPVVHIRDN MDLQPARYRI
LMKGVEIGSG DAYPGRWLAI NPGTAAGTLP GEKTVDPAFG LDAIWIESAL KEQAQIQGFT
VVEASTVVAT HLNHLIGQFS AELFGRQEAQ QLLDRVSQEM PKLTEDLVPG VVTLTTLHKV
LQNLLAEKVP IRDMRTILET LAEHAPLQSD PHELTAVVRV ALGRAITQQW FPGNEEVQVI
GLDTALERLL LQALQGGGGL EPGLADRLLA QTQEALSRQE MLGAPPVLLV NHALRPLLSR
FLRRSLPQLV VLSNLELSDN RHIRMTATIG GK
