ID   FLHA_TREPA              Reviewed;         707 AA.
AC   Q56338;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 123.
DE   RecName: Full=Flagellar biosynthesis protein FlhA;
GN   Name=flhA; OrderedLocusNames=TP_0714;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9063647; DOI=10.3109/10425179709020157;
RA   Hardham J.M., Frye J.G., Young N.R., Stamm L.V.;
RT   "Identification and sequences of the Treponema pallidum flhA, flhF, and
RT   orf304 genes.";
RL   DNA Seq. 7:107-116(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- FUNCTION: Involved in the export of flagellum proteins.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC       pore) family. {ECO:0000305}.
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DR   EMBL; U36839; AAB00550.1; -; Genomic_DNA.
DR   EMBL; AE000520; AAC65680.1; -; Genomic_DNA.
DR   PIR; F71290; F71290.
DR   RefSeq; WP_010882159.1; NC_021490.2.
DR   AlphaFoldDB; Q56338; -.
DR   SMR; Q56338; -.
DR   IntAct; Q56338; 2.
DR   STRING; 243276.TPANIC_0714; -.
DR   EnsemblBacteria; AAC65680; AAC65680; TP_0714.
DR   GeneID; 57879239; -.
DR   KEGG; tpa:TP_0714; -.
DR   eggNOG; COG1298; Bacteria.
DR   HOGENOM; CLU_015346_3_0_12; -.
DR   OMA; MAINPGQ; -.
DR   OrthoDB; 436367at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 1.10.8.540; -; 1.
DR   Gene3D; 3.40.30.60; -; 1.
DR   Gene3D; 3.40.50.12790; -; 1.
DR   InterPro; IPR042194; FHIPEP_1.
DR   InterPro; IPR042193; FHIPEP_3.
DR   InterPro; IPR042196; FHIPEP_4.
DR   InterPro; IPR006301; FlhA.
DR   InterPro; IPR001712; T3SS_FHIPEP.
DR   PANTHER; PTHR30161; PTHR30161; 1.
DR   Pfam; PF00771; FHIPEP; 1.
DR   PIRSF; PIRSF005419; FlhA; 1.
DR   PRINTS; PR00949; TYPE3IMAPROT.
DR   TIGRFAMs; TIGR01398; FlhA; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum biogenesis; Bacterial flagellum protein export;
KW   Cell membrane; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..707
FT                   /note="Flagellar biosynthesis protein FlhA"
FT                   /id="PRO_0000190021"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        290..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          329..350
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   707 AA;  77944 MW;  12468B80C5922C14 CRC64;
     MAHGKSAFFT TDAFVAISVL VVVFSIVVPL PTQILDALMA FNLIFNLLIL LMVLFVEKPT
     DFSVFPSLLL TSTVFGLGLN VSSTRLILTL GDRFSGYMIR AFSSFVVGGS GTQGLVIGFT
     VFIILIAVQA FVITKGATRI AEVAARFTLD FNATKSMSID AEYNAGVITE EEARERKRQI
     QREADFFGAM DGASKFVSGN VKIGIFITIV NVIAGLIVGV IFRREGFQAA LQTYTNLTIG
     DGLLAQLPSL LLSVATGFIV TRSSDQGSFG QNVQEQFSKS ALVYFIGSGA LIVMAVLPGF
     PHSILFFMAV CFAFVGLQLR KRERVHVQEH EMQKSSDKKG MQQTQDSTSE MGPIVPLDPL
     SLELGYGLIP LVDKEKGAEL LSRITVIRKD AALDLGLVAP KIRIIDNMRL DPSSYCFKIQ
     GLEVARGKLR LGWFLAIKSG QVTEEVPGER TIDPTFGLPA VWISEENRDR AERVGYTVVA
     PSAIIATHLT QVIRTNAADI LGRQNVQMII DALRKEYPAV VDDVTQKCPL GKIQKVLQGL
     LREQVSIRNT VAIFETLADF ASTSDTVPVP ILIEKVRQRL GRQICLQYAD EQNVLHVMRL
     DSSLETFLSE KIALTVDSLS ILTLSLDEQR QVLQAVRTVF VPTRQEGYIP VLLTTDTIRS
     AMWNLFFSDR IEIAVMSYKE VSTDMRIETV GVVRIEESDV DAFVRKQ