FLHB_SALTY
ID FLHB_SALTY Reviewed; 383 AA.
AC P40727; Q6LDV3;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Flagellar biosynthetic protein FlhB;
GN Name=flhB; OrderedLocusNames=STM1914;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KK1004;
RX PubMed=8002587; DOI=10.1128/jb.176.24.7630-7637.1994;
RA Minamino T., Iino T., Kutsukake K.;
RT "Molecular characterization of the Salmonella typhimurium flhB operon and
RT its protein products.";
RL J. Bacteriol. 176:7630-7637(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-213.
RX PubMed=3298217; DOI=10.1128/jb.169.7.3301-3311.1987;
RA Stock A.M., Stock J.B.;
RT "Purification and characterization of the CheZ protein of bacterial
RT chemotaxis.";
RL J. Bacteriol. 169:3301-3311(1987).
CC -!- FUNCTION: Required for formation of the rod structure in the basal body
CC of the flagellar apparatus. Together with FliI and FliH, may constitute
CC the export apparatus of flagellin.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the type III secretion exporter family.
CC {ECO:0000305}.
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DR EMBL; D32203; BAA06902.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL20830.1; -; Genomic_DNA.
DR EMBL; M16691; AAD15121.1; -; Genomic_DNA.
DR PIR; A55546; A55546.
DR RefSeq; NP_460871.1; NC_003197.2.
DR RefSeq; WP_000797081.1; NC_003197.2.
DR PDB; 3B0Z; X-ray; 2.45 A; A=219-269, B=270-383.
DR PDBsum; 3B0Z; -.
DR AlphaFoldDB; P40727; -.
DR SMR; P40727; -.
DR IntAct; P40727; 1.
DR STRING; 99287.STM1914; -.
DR TCDB; 3.A.6.2.1; the type iii (virulence-related) secretory pathway (iiisp) family.
DR PaxDb; P40727; -.
DR EnsemblBacteria; AAL20830; AAL20830; STM1914.
DR GeneID; 1253435; -.
DR KEGG; stm:STM1914; -.
DR PATRIC; fig|99287.12.peg.2030; -.
DR HOGENOM; CLU_041013_1_2_6; -.
DR OMA; DEYKQQE; -.
DR PhylomeDB; P40727; -.
DR BioCyc; SENT99287:STM1914-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 3.40.1690.10; -; 1.
DR InterPro; IPR006136; FlhB.
DR InterPro; IPR006135; T3SS_substrate_exporter.
DR InterPro; IPR029025; T3SS_substrate_exporter_C.
DR PANTHER; PTHR30531; PTHR30531; 1.
DR Pfam; PF01312; Bac_export_2; 1.
DR PRINTS; PR00950; TYPE3IMSPROT.
DR SUPFAM; SSF160544; SSF160544; 1.
DR TIGRFAMs; TIGR00328; flhB; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Bacterial flagellum biogenesis;
KW Bacterial flagellum protein export; Cell inner membrane; Cell membrane;
KW Membrane; Protein transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..383
FT /note="Flagellar biosynthetic protein FlhB"
FT /id="PRO_0000180950"
FT TOPO_DOM 1..32
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 117..145
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..190
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..383
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 230..236
FT /evidence="ECO:0007829|PDB:3B0Z"
FT HELIX 238..258
FT /evidence="ECO:0007829|PDB:3B0Z"
FT HELIX 259..262
FT /evidence="ECO:0007829|PDB:3B0Z"
FT STRAND 264..269
FT /evidence="ECO:0007829|PDB:3B0Z"
FT STRAND 273..278
FT /evidence="ECO:0007829|PDB:3B0Z"
FT STRAND 288..293
FT /evidence="ECO:0007829|PDB:3B0Z"
FT HELIX 296..307
FT /evidence="ECO:0007829|PDB:3B0Z"
FT STRAND 312..314
FT /evidence="ECO:0007829|PDB:3B0Z"
FT HELIX 316..325
FT /evidence="ECO:0007829|PDB:3B0Z"
FT HELIX 334..336
FT /evidence="ECO:0007829|PDB:3B0Z"
FT HELIX 337..350
FT /evidence="ECO:0007829|PDB:3B0Z"
SQ SEQUENCE 383 AA; 42355 MW; 742BA0BBED9DF238 CRC64;
MAEESDDDKT EAPTPHRLEK AREEGQIPRS RELTSLLILL VGVCIIWFGG ESLARQLAGM
LSAGLHFDHR MVNDPNLILG QIILLIKAAM MALLPLIAGV VLVALISPVM LGGLIFSGKS
LQPKFSKLNP LPGIKRMFSA QTGAELLKAV LKSTLVGCVT GFYLWHHWPQ MMRLMAESPI
VAMGNALDLV GLCALLVVLG VIPMVGFDVF FQIFSHLKKL RMSRQDIRDE FKESEGDPHV
KGKIRQMQRA AAQRRMMEDV PKADVIVTNP THYSVALQYD ENKMSAPKVV AKGAGLIALR
IREIGAEHRV PTLEAPPLAR ALYRHAEIGQ QIPGQLYAAV AEVLAWVWQL KRWRLAGGQR
PPQPENLPVP EALDFMNEKN TDG
