ID   FLHB_TREPA              Reviewed;         376 AA.
AC   O83710; Q56337;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 121.
DE   RecName: Full=Flagellar biosynthetic protein FlhB;
GN   Name=flhB; OrderedLocusNames=TP_0715;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=8529894; DOI=10.1016/0378-1119(95)00583-x;
RA   Hardham J.M., Frye J.G., Stamm L.V.;
RT   "Identification and sequences of the Treponema pallidum fliM', fliY, fliP,
RT   fliQ, fliR and flhB' genes.";
RL   Gene 166:57-64(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- FUNCTION: Required for formation of the rod structure in the basal body
CC       of the flagellar apparatus. Together with FliI and FliH, may constitute
CC       the export apparatus of flagellin (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the type III secretion exporter family.
CC       {ECO:0000305}.
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DR   EMBL; U36839; AAB00549.1; -; Genomic_DNA.
DR   EMBL; AE000520; AAC65681.1; -; Genomic_DNA.
DR   PIR; G71290; G71290.
DR   RefSeq; WP_010882160.1; NC_021490.2.
DR   AlphaFoldDB; O83710; -.
DR   SMR; O83710; -.
DR   IntAct; O83710; 2.
DR   STRING; 243276.TPANIC_0715; -.
DR   PRIDE; O83710; -.
DR   EnsemblBacteria; AAC65681; AAC65681; TP_0715.
DR   KEGG; tpa:TP_0715; -.
DR   eggNOG; COG1377; Bacteria.
DR   HOGENOM; CLU_041013_1_2_12; -.
DR   OMA; DEYKQQE; -.
DR   OrthoDB; 1424100at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 3.40.1690.10; -; 1.
DR   InterPro; IPR006136; FlhB.
DR   InterPro; IPR006135; T3SS_substrate_exporter.
DR   InterPro; IPR029025; T3SS_substrate_exporter_C.
DR   PANTHER; PTHR30531; PTHR30531; 1.
DR   Pfam; PF01312; Bac_export_2; 1.
DR   PRINTS; PR00950; TYPE3IMSPROT.
DR   SUPFAM; SSF160544; SSF160544; 1.
DR   TIGRFAMs; TIGR00328; flhB; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum biogenesis; Bacterial flagellum protein export;
KW   Cell inner membrane; Cell membrane; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..376
FT                   /note="Flagellar biosynthetic protein FlhB"
FT                   /id="PRO_0000180954"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        357..376
FT                   /note="ALVLIFTKLDKFKTHAQRKR -> CFSADFYQAG (in Ref. 1;
FT                   AAB00549)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   376 AA;  43039 MW;  FEA32E2E8B269540 CRC64;
     MIEQEGTFPL PLFIIDLQWF AAEDEGRSED PTETKLRKAR EEGRVPKSQD LNGAFVMLFT
     STSLFLLAPF ILRECIGVLR FFFTRATTAS IQNTGWFFVF VRYFMKLALP ISFVALVSGV
     AANIVQNKTV LFSVKSIRPQ FKKISPDVIR FFKRSFFSTE GLFNLLKSLI KITAIFFVSY
     FTIRNDLFMF VSLLGVSLTQ SIFYITSLAG KVLLEVSLLL VVFSLPDYFF QRRQFIDSLK
     MSRQEVKEEL KEQEGDPLVR SYVRKQMQSL VRESARNTTD ADVVITNPTH FAVAVQYEPA
     YMTAPTVVAK GSDGTAYRIK RLAKEAGILI EENKPLARAL YTQVAIGREV PYEYFNALVL
     IFTKLDKFKT HAQRKR