ID   FLHC_ENTCC              Reviewed;         191 AA.
AC   D5CIL6;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Flagellar transcriptional regulator FlhC {ECO:0000255|HAMAP-Rule:MF_01891};
GN   Name=flhC {ECO:0000255|HAMAP-Rule:MF_01891}; OrderedLocusNames=ECL_03263;
OS   Enterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC
OS   13535 / NCTC 10005 / WDCM 00083 / NCDC 279-56).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex.
OX   NCBI_TaxID=716541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13047 / DSM 30054 / NBRC 13535 / NCTC 10005 / WDCM 00083 / NCDC
RC   279-56;
RX   PubMed=20207761; DOI=10.1128/jb.00067-10;
RA   Ren Y., Ren Y., Zhou Z., Guo X., Li Y., Feng L., Wang L.;
RT   "Complete genome sequence of Enterobacter cloacae subsp. cloacae type
RT   strain ATCC 13047.";
RL   J. Bacteriol. 192:2463-2464(2010).
CC   -!- FUNCTION: Functions in complex with FlhD as a master transcriptional
CC       regulator that regulates transcription of several flagellar and non-
CC       flagellar operons by binding to their promoter region. Activates
CC       expression of class 2 flagellar genes, including fliA, which is a
CC       flagellum-specific sigma factor that turns on the class 3 genes. Also
CC       regulates genes whose products function in a variety of physiological
CC       pathways. {ECO:0000255|HAMAP-Rule:MF_01891}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01891};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01891};
CC   -!- SUBUNIT: Heterohexamer composed of two FlhC and four FlhD subunits.
CC       Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer
CC       assembles by dimerization of two heterotrimers. {ECO:0000255|HAMAP-
CC       Rule:MF_01891}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01891}.
CC   -!- SIMILARITY: Belongs to the FlhC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01891}.
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DR   EMBL; CP001918; ADF62797.1; -; Genomic_DNA.
DR   RefSeq; WP_013097769.1; NC_014121.1.
DR   RefSeq; YP_003613746.1; NC_014121.1.
DR   AlphaFoldDB; D5CIL6; -.
DR   SMR; D5CIL6; -.
DR   STRING; 716541.ECL_03263; -.
DR   EnsemblBacteria; ADF62797; ADF62797; ECL_03263.
DR   KEGG; enc:ECL_03263; -.
DR   PATRIC; fig|716541.4.peg.3426; -.
DR   eggNOG; ENOG502ZD66; Bacteria.
DR   HOGENOM; CLU_122824_0_0_6; -.
DR   OMA; NEARCSH; -.
DR   Proteomes; UP000002363; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:1902208; P:regulation of bacterial-type flagellum assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01891; FhlC; 1.
DR   InterPro; IPR007944; FlhC.
DR   Pfam; PF05280; FlhC; 1.
DR   PIRSF; PIRSF003159; FlhC; 1.
PE   3: Inferred from homology;
KW   Activator; Bacterial flagellum biogenesis; Cytoplasm; DNA-binding;
KW   Metal-binding; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..191
FT                   /note="Flagellar transcriptional regulator FlhC"
FT                   /id="PRO_0000406760"
FT   BINDING         139
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT   BINDING         142
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT   BINDING         159
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT   BINDING         162
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
SQ   SEQUENCE   191 AA;  21591 MW;  8A37DA5C1FA7C4FD CRC64;
     MCGEKSLLQE IDEVNIAMGL ISLGARMQVL ESETSLSRRR LLRLYKELRG CPPPKGMLPF
     SEDWFMSWEQ NIHSSMFYNI YLYLKKTEQG RSIEMLMKTY RLYLEQCSTC SDEKPVLGLT
     RAWTLLRFID CGIISRKACS VCGGGFIVTT EFIKNPFTCS LCSPPSRALK KSQVSNTGLL
     GTFAAPEIMT A