FLHC_ERWT9
ID FLHC_ERWT9 Reviewed; 178 AA.
AC B2VDW1;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Flagellar transcriptional regulator FlhC {ECO:0000255|HAMAP-Rule:MF_01891};
GN Name=flhC {ECO:0000255|HAMAP-Rule:MF_01891}; OrderedLocusNames=ETA_09510;
OS Erwinia tasmaniensis (strain DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB
OS 4357 / Et1/99).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Erwinia.
OX NCBI_TaxID=465817;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB 4357 / Et1/99;
RX PubMed=18462403; DOI=10.1111/j.1462-2920.2008.01639.x;
RA Kube M., Migdoll A.M., Mueller I., Kuhl H., Beck A., Reinhardt R.,
RA Geider K.;
RT "The genome of Erwinia tasmaniensis strain Et1/99, a non-pathogenic
RT bacterium in the genus Erwinia.";
RL Environ. Microbiol. 10:2211-2222(2008).
CC -!- FUNCTION: Functions in complex with FlhD as a master transcriptional
CC regulator that regulates transcription of several flagellar and non-
CC flagellar operons by binding to their promoter region. Activates
CC expression of class 2 flagellar genes, including fliA, which is a
CC flagellum-specific sigma factor that turns on the class 3 genes. Also
CC regulates genes whose products function in a variety of physiological
CC pathways. {ECO:0000255|HAMAP-Rule:MF_01891}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01891};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01891};
CC -!- SUBUNIT: Heterohexamer composed of two FlhC and four FlhD subunits.
CC Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer
CC assembles by dimerization of two heterotrimers. {ECO:0000255|HAMAP-
CC Rule:MF_01891}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01891}.
CC -!- SIMILARITY: Belongs to the FlhC family. {ECO:0000255|HAMAP-
CC Rule:MF_01891}.
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DR EMBL; CU468135; CAO95997.1; -; Genomic_DNA.
DR AlphaFoldDB; B2VDW1; -.
DR SMR; B2VDW1; -.
DR STRING; 465817.ETA_09510; -.
DR EnsemblBacteria; CAO95997; CAO95997; ETA_09510.
DR KEGG; eta:ETA_09510; -.
DR eggNOG; ENOG502ZD66; Bacteria.
DR HOGENOM; CLU_122824_0_0_6; -.
DR OMA; NEARCSH; -.
DR Proteomes; UP000001726; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:1902208; P:regulation of bacterial-type flagellum assembly; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01891; FhlC; 1.
DR InterPro; IPR007944; FlhC.
DR Pfam; PF05280; FlhC; 1.
DR PIRSF; PIRSF003159; FlhC; 1.
PE 3: Inferred from homology;
KW Activator; Bacterial flagellum biogenesis; Cytoplasm; DNA-binding;
KW Metal-binding; Reference proteome; Transcription; Transcription regulation;
KW Zinc.
FT CHAIN 1..178
FT /note="Flagellar transcriptional regulator FlhC"
FT /id="PRO_0000406761"
FT BINDING 138
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT BINDING 141
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT BINDING 158
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT BINDING 161
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
SQ SEQUENCE 178 AA; 20403 MW; 92E71F546D11308B CRC64;
MIGKKVLDEI YEINIAMELI VLGARMQVLE SETSVSRRRL VRLYKEIRGC PPPKGMLPFS
EDWFMCWEQN IHSSLFYNIY LCLQKTENER PITTLMQAYR LYLEQCYPHS SETPVLGLTR
AWTLLRFIGC GMISRKSCML CAGGFVMVTE FIKEPFTCSL CCPPSRALKK FSATSGSS