FLHC_GALCS
ID FLHC_GALCS Reviewed; 182 AA.
AC D9SEU0;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 1.
DT 03-AUG-2022, entry version 51.
DE RecName: Full=Flagellar transcriptional regulator FlhC {ECO:0000255|HAMAP-Rule:MF_01891};
GN Name=flhC {ECO:0000255|HAMAP-Rule:MF_01891}; OrderedLocusNames=Galf_1007;
OS Gallionella capsiferriformans (strain ES-2) (Gallionella ferruginea
OS capsiferriformans (strain ES-2)).
OC Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC Gallionellaceae; Gallionella.
OX NCBI_TaxID=395494;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ES-2;
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Chertkov O., Davenport K.W., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Chang Y.-J., Jeffries C., Kyrpides N., Ivanova N.,
RA Mikhailova N., Shelobolina E.S., Picardal F., Roden E., Emerson D.,
RA Woyke T.;
RT "Complete sequence of Gallionella capsiferriformans ES-2.";
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions in complex with FlhD as a master transcriptional
CC regulator that regulates transcription of several flagellar and non-
CC flagellar operons by binding to their promoter region. Activates
CC expression of class 2 flagellar genes, including fliA, which is a
CC flagellum-specific sigma factor that turns on the class 3 genes. Also
CC regulates genes whose products function in a variety of physiological
CC pathways. {ECO:0000255|HAMAP-Rule:MF_01891}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01891};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01891};
CC -!- SUBUNIT: Heterohexamer composed of two FlhC and four FlhD subunits.
CC Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer
CC assembles by dimerization of two heterotrimers. {ECO:0000255|HAMAP-
CC Rule:MF_01891}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01891}.
CC -!- SIMILARITY: Belongs to the FlhC family. {ECO:0000255|HAMAP-
CC Rule:MF_01891}.
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DR EMBL; CP002159; ADL55037.1; -; Genomic_DNA.
DR RefSeq; WP_013292977.1; NC_014394.1.
DR AlphaFoldDB; D9SEU0; -.
DR SMR; D9SEU0; -.
DR STRING; 395494.Galf_1007; -.
DR EnsemblBacteria; ADL55037; ADL55037; Galf_1007.
DR KEGG; gca:Galf_1007; -.
DR eggNOG; ENOG502Z927; Bacteria.
DR HOGENOM; CLU_122824_0_0_4; -.
DR OMA; MLQLSAC; -.
DR OrthoDB; 1247512at2; -.
DR Proteomes; UP000001235; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:1902208; P:regulation of bacterial-type flagellum assembly; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01891; FhlC; 1.
DR InterPro; IPR007944; FlhC.
DR Pfam; PF05280; FlhC; 1.
DR PIRSF; PIRSF003159; FlhC; 1.
PE 3: Inferred from homology;
KW Activator; Bacterial flagellum biogenesis; Cytoplasm; DNA-binding;
KW Metal-binding; Reference proteome; Transcription; Transcription regulation;
KW Zinc.
FT CHAIN 1..182
FT /note="Flagellar transcriptional regulator FlhC"
FT /id="PRO_0000406762"
FT BINDING 138
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT BINDING 141
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT BINDING 158
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT BINDING 161
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
SQ SEQUENCE 182 AA; 20370 MW; 364CD99BAE306560 CRC64;
MAIKTVLGEA QQIKIATDLI VLGARLQVLQ EETSLSRERL LKLYKEVRGE SPSKGMLPYS
TDWFISWQPN IHSSLFMGIY QFMIKNAGVD GVHALISAYR LYLDQVQGIE GGEVVLSITR
AWFLVRFFKA GMMQLITCRE CSGKFVTHTN ELHNNYVCGI CHPPARAGKT NAKARLLAGH
AE