ID   FLHC_PROMI              Reviewed;         193 AA.
AC   O34202;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Flagellar transcriptional regulator FlhC {ECO:0000255|HAMAP-Rule:MF_01891};
GN   Name=flhC {ECO:0000255|HAMAP-Rule:MF_01891};
OS   Proteus mirabilis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Proteus.
OX   NCBI_TaxID=584;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=U6450;
RX   PubMed=9287017; DOI=10.1128/jb.179.17.5585-5588.1997;
RA   Furness R.B., Fraser G.M., Hay N.A., Hughes C.;
RT   "Negative feedback from a Proteus class II flagellum export defect to the
RT   flhDC master operon controlling cell division and flagellum assembly.";
RL   J. Bacteriol. 179:5585-5588(1997).
RN   [2]
RP   FUNCTION, INTERACTION WITH FLHD, AND DNA-BINDING.
RC   STRAIN=U6450;
RX   PubMed=12144778; DOI=10.1016/s0022-2836(02)00600-9;
RA   Claret L., Hughes C.;
RT   "Interaction of the atypical prokaryotic transcription activator FlhD2C2
RT   with early promoters of the flagellar gene hierarchy.";
RL   J. Mol. Biol. 321:185-199(2002).
CC   -!- FUNCTION: Functions in complex with FlhD as a master transcriptional
CC       regulator that regulates transcription of several flagellar and non-
CC       flagellar operons by binding to their promoter region. Activates
CC       expression of class 2 flagellar genes, including fliA, which is a
CC       flagellum-specific sigma factor that turns on the class 3 genes. Also
CC       regulates genes whose products function in a variety of physiological
CC       pathways. {ECO:0000255|HAMAP-Rule:MF_01891,
CC       ECO:0000269|PubMed:12144778}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01891};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01891};
CC   -!- SUBUNIT: Heterohexamer composed of two FlhC and four FlhD subunits.
CC       Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer
CC       assembles by dimerization of two heterotrimers. {ECO:0000255|HAMAP-
CC       Rule:MF_01891}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01891}.
CC   -!- SIMILARITY: Belongs to the FlhC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01891}.
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DR   EMBL; U96964; AAB69768.1; -; Genomic_DNA.
DR   AlphaFoldDB; O34202; -.
DR   SMR; O34202; -.
DR   STRING; 584.AOUC001_07215; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:1902208; P:regulation of bacterial-type flagellum assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01891; FhlC; 1.
DR   InterPro; IPR007944; FlhC.
DR   Pfam; PF05280; FlhC; 1.
DR   PIRSF; PIRSF003159; FlhC; 1.
PE   1: Evidence at protein level;
KW   Activator; Bacterial flagellum biogenesis; Cytoplasm; DNA-binding;
KW   Metal-binding; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..193
FT                   /note="Flagellar transcriptional regulator FlhC"
FT                   /id="PRO_0000064341"
FT   BINDING         138
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT   BINDING         141
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT   BINDING         158
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT   BINDING         161
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
SQ   SEQUENCE   193 AA;  21927 MW;  EC8729C44A15B129 CRC64;
     MSEKSIVREA KDIRLAMELI TLGARLQMLE SETQLSRGRL IKLYKELRGS PPPKGMLPFS
     TDWFMTWEQN IHSSMFYNAY RFLLKSGGSV GIEAVVKAYR LYLEQCPPVK DQEPILALTR
     AWTLVRFVES GMLQLSVCTK CNGSFITHAH QPASNYVCSL CQPPSRAIKK RKLSANPADI
     NLQLLDGLEQ FRM