FLHC_SALTY
ID FLHC_SALTY Reviewed; 192 AA.
AC O52222;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Flagellar transcriptional regulator FlhC {ECO:0000255|HAMAP-Rule:MF_01891};
GN Name=flhC {ECO:0000255|HAMAP-Rule:MF_01891}; OrderedLocusNames=STM1924;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RA Toguchi A., Harshey R.M.;
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10586519; DOI=10.1266/ggs.74.105;
RA Yanagihara S., Iyoda S., Ohnishi K., Iino T., Kutsukake K.;
RT "Structure and transcriptional control of the flagellar master operon of
RT Salmonella typhimurium.";
RL Genes Genet. Syst. 74:105-111(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [4]
RP INDUCTION.
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=21278297; DOI=10.1128/jb.01494-10;
RA Wada T., Morizane T., Abo T., Tominaga A., Inoue-Tanaka K., Kutsukake K.;
RT "EAL domain protein YdiV acts as an anti-FlhD4C2 factor responsible for
RT nutritional control of the flagellar regulon in Salmonella enterica Serovar
RT Typhimurium.";
RL J. Bacteriol. 193:1600-1611(2011).
CC -!- FUNCTION: Functions in complex with FlhD as a master transcriptional
CC regulator that regulates transcription of several flagellar and non-
CC flagellar operons by binding to their promoter region. Activates
CC expression of class 2 flagellar genes, including fliA, which is a
CC flagellum-specific sigma factor that turns on the class 3 genes. Also
CC regulates genes whose products function in a variety of physiological
CC pathways (Probable). {ECO:0000305}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01891};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01891};
CC -!- SUBUNIT: Heterohexamer composed of two FlhC and four FlhD subunits.
CC Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer
CC assembles by dimerization of two heterotrimers (Probable). YdiV binds
CC to FlhD which inhibits the ability of FlhC(2)FlhD(4) to bind DNA.
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01891}.
CC -!- SIMILARITY: Belongs to the FlhC family. {ECO:0000255|HAMAP-
CC Rule:MF_01891}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL20840.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF029300; AAB96640.1; -; Genomic_DNA.
DR EMBL; D43640; BAA85315.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL20840.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_460881.3; NC_003197.2.
DR AlphaFoldDB; O52222; -.
DR SMR; O52222; -.
DR IntAct; O52222; 1.
DR STRING; 99287.STM1924; -.
DR PaxDb; O52222; -.
DR PRIDE; O52222; -.
DR DNASU; 1253445; -.
DR EnsemblBacteria; AAL20840; AAL20840; STM1924.
DR GeneID; 1253445; -.
DR KEGG; stm:STM1924; -.
DR PATRIC; fig|99287.12.peg.2041; -.
DR HOGENOM; CLU_122824_0_0_6; -.
DR OMA; MLQLSAC; -.
DR PhylomeDB; O52222; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:1902208; P:regulation of bacterial-type flagellum assembly; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01891; FhlC; 1.
DR InterPro; IPR007944; FlhC.
DR Pfam; PF05280; FlhC; 1.
DR PIRSF; PIRSF003159; FlhC; 1.
PE 2: Evidence at transcript level;
KW Activator; Bacterial flagellum biogenesis; Cytoplasm; DNA-binding;
KW Metal-binding; Reference proteome; Transcription; Transcription regulation;
KW Zinc.
FT CHAIN 1..192
FT /note="Flagellar transcriptional regulator FlhC"
FT /id="PRO_0000064342"
FT BINDING 137
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT BINDING 140
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT BINDING 157
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT BINDING 160
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
SQ SEQUENCE 192 AA; 21579 MW; C7334C691ECE3F8D CRC64;
MSEKSIVQEA RDIQLAMELI NLGARLQMLE SETQLSRGRL IRLYKELRGS PPPKGMLPFS
TDWFMTWEQN IHASMFCNAW QFLLKTGLCS GVDAVIKAYR LYLEQCPQPP EGPLLALTRA
WTLVRFVESG LLELSSCNCC GGNFITHAHQ PVGSFACSLC QPPSRAVKRR KLSRDAADII
PQLLDEQIEQ AV
