FLHC_SERMA
ID FLHC_SERMA Reviewed; 194 AA.
AC O85807;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Flagellar transcriptional regulator FlhC {ECO:0000255|HAMAP-Rule:MF_01891};
GN Name=flhC {ECO:0000255|HAMAP-Rule:MF_01891};
OS Serratia marcescens.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Serratia.
OX NCBI_TaxID=615;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=CH1;
RX PubMed=11060496; DOI=10.1159/000025483;
RA Lai H.C., Luh K.T., Ho S.W., Swift S.;
RT "Role of flhDC in the expression of the nuclease gene nucA, cell division
RT and flagellar synthesis in Serratia marcescens.";
RL J. Biomed. Sci. 7:475-483(2000).
CC -!- FUNCTION: Functions in complex with FlhD as a master transcriptional
CC regulator that regulates transcription of several flagellar and non-
CC flagellar operons by binding to their promoter region. Activates
CC expression of class 2 flagellar genes, including fliA, which is a
CC flagellum-specific sigma factor that turns on the class 3 genes. Also
CC regulates genes whose products function in a variety of physiological
CC pathways. {ECO:0000255|HAMAP-Rule:MF_01891}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01891};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01891};
CC -!- SUBUNIT: Heterohexamer composed of two FlhC and four FlhD subunits.
CC Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer
CC assembles by dimerization of two heterotrimers. {ECO:0000255|HAMAP-
CC Rule:MF_01891}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01891}.
CC -!- SIMILARITY: Belongs to the FlhC family. {ECO:0000255|HAMAP-
CC Rule:MF_01891}.
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DR EMBL; AF077334; AAC27634.1; -; Genomic_DNA.
DR AlphaFoldDB; O85807; -.
DR SMR; O85807; -.
DR STRING; 273526.SMDB11_2237; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:1902208; P:regulation of bacterial-type flagellum assembly; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01891; FhlC; 1.
DR InterPro; IPR007944; FlhC.
DR Pfam; PF05280; FlhC; 1.
DR PIRSF; PIRSF003159; FlhC; 1.
PE 3: Inferred from homology;
KW Activator; Bacterial flagellum biogenesis; Cytoplasm; DNA-binding;
KW Metal-binding; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..194
FT /note="Flagellar transcriptional regulator FlhC"
FT /id="PRO_0000064344"
FT BINDING 139
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT BINDING 142
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT BINDING 159
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT BINDING 162
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
SQ SEQUENCE 194 AA; 21810 MW; E57993DB273AD2DD CRC64;
MMVEKSIVQE AKDIQLAMEL ISLGARLQML ESETQLSRGR LIKLYKELRG SPPPKGMLPF
STDWFMTWEQ NIHSSMFYNA YLFLMKSGQC SGVEAVIKAY RLYLEQCPQQ AGEAPLLALT
RAWTLVRFVD SGMLQLSACS CCGGAFITHA HQPLNGFICS LCQPPSRAVK RRKLSPQLAD
IIPQLLDEQV KRAI