ID   FLHC_SODGM              Reviewed;         196 AA.
AC   Q2NX28;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Flagellar transcriptional regulator FlhC {ECO:0000255|HAMAP-Rule:MF_01891};
GN   Name=flhC {ECO:0000255|HAMAP-Rule:MF_01891}; OrderedLocusNames=SG0022;
OS   Sodalis glossinidius (strain morsitans).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Bruguierivoracaceae; Sodalis.
OX   NCBI_TaxID=343509;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=morsitans;
RX   PubMed=16365377; DOI=10.1101/gr.4106106;
RA   Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M.,
RA   Aksoy S.;
RT   "Massive genome erosion and functional adaptations provide insights into
RT   the symbiotic lifestyle of Sodalis glossinidius in the tsetse host.";
RL   Genome Res. 16:149-156(2006).
CC   -!- FUNCTION: Functions in complex with FlhD as a master transcriptional
CC       regulator that regulates transcription of several flagellar and non-
CC       flagellar operons by binding to their promoter region. Activates
CC       expression of class 2 flagellar genes, including fliA, which is a
CC       flagellum-specific sigma factor that turns on the class 3 genes. Also
CC       regulates genes whose products function in a variety of physiological
CC       pathways. {ECO:0000255|HAMAP-Rule:MF_01891}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01891};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01891};
CC   -!- SUBUNIT: Heterohexamer composed of two FlhC and four FlhD subunits.
CC       Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer
CC       assembles by dimerization of two heterotrimers. {ECO:0000255|HAMAP-
CC       Rule:MF_01891}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01891}.
CC   -!- SIMILARITY: Belongs to the FlhC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01891}.
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DR   EMBL; AP008232; BAE73297.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2NX28; -.
DR   SMR; Q2NX28; -.
DR   STRING; 343509.SG0022; -.
DR   EnsemblBacteria; BAE73297; BAE73297; SG0022.
DR   KEGG; sgl:SG0022; -.
DR   eggNOG; ENOG502Z927; Bacteria.
DR   HOGENOM; CLU_122824_0_0_6; -.
DR   OMA; NEARCSH; -.
DR   Proteomes; UP000001932; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:1902208; P:regulation of bacterial-type flagellum assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01891; FhlC; 1.
DR   InterPro; IPR007944; FlhC.
DR   Pfam; PF05280; FlhC; 1.
DR   PIRSF; PIRSF003159; FlhC; 1.
PE   3: Inferred from homology;
KW   Activator; Bacterial flagellum biogenesis; Cytoplasm; DNA-binding;
KW   Metal-binding; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..196
FT                   /note="Flagellar transcriptional regulator FlhC"
FT                   /id="PRO_0000406765"
FT   BINDING         138
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT   BINDING         141
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT   BINDING         158
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT   BINDING         161
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
SQ   SEQUENCE   196 AA;  22473 MW;  0CBAA38398CA54E6 CRC64;
     MYRKSIMQES RDIQLAMELI ALGARLPILE NETCLSRSRL LRLYKEVKGT PAPKGLLPFS
     ADWFLSWEQN IHSSAFYNAY LCLIRVGNIP TIEAMIKAYR LYLELCPQRQ DGGPLLGLTR
     AWILLRFIDS QLLGQTRCKL CGGAFITYAF HPPHNFVCSF CHPPSRAVKK RKLSHAAADN
     RIYNLRQRNM CNVKPC