ID   FLHC_YEREN              Reviewed;         193 AA.
AC   O86047;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Flagellar transcriptional regulator FlhC {ECO:0000255|HAMAP-Rule:MF_01891};
GN   Name=flhC {ECO:0000255|HAMAP-Rule:MF_01891};
OS   Yersinia enterocolitica.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=630;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=8081V / Serotype O:8;
RX   PubMed=10217774; DOI=10.1128/jb.181.9.2823-2833.1999;
RA   Young G.M., Smith M.J., Minnich S.A., Miller V.L.;
RT   "The Yersinia enterocolitica motility master regulatory operon, flhDC, is
RT   required for flagellin production, swimming motility, and swarming
RT   motility.";
RL   J. Bacteriol. 181:2823-2833(1999).
CC   -!- FUNCTION: Functions in complex with FlhD as a master transcriptional
CC       regulator that regulates transcription of several flagellar and non-
CC       flagellar operons by binding to their promoter region. Activates
CC       expression of class 2 flagellar genes, including fliA, which is a
CC       flagellum-specific sigma factor that turns on the class 3 genes. Also
CC       regulates genes whose products function in a variety of physiological
CC       pathways (Probable). {ECO:0000305|PubMed:10217774}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01891};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01891};
CC   -!- SUBUNIT: Heterohexamer composed of two FlhC and four FlhD subunits.
CC       Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer
CC       assembles by dimerization of two heterotrimers. {ECO:0000255|HAMAP-
CC       Rule:MF_01891}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01891}.
CC   -!- SIMILARITY: Belongs to the FlhC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01891}.
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DR   EMBL; AF081587; AAC31211.1; -; Genomic_DNA.
DR   RefSeq; WP_005164496.1; NZ_UHIX01000001.1.
DR   AlphaFoldDB; O86047; -.
DR   SMR; O86047; -.
DR   STRING; 1443113.LC20_02133; -.
DR   GeneID; 67421582; -.
DR   eggNOG; ENOG502Z927; Bacteria.
DR   OMA; MLQLSAC; -.
DR   OrthoDB; 1247512at2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:1902208; P:regulation of bacterial-type flagellum assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01891; FhlC; 1.
DR   InterPro; IPR007944; FlhC.
DR   Pfam; PF05280; FlhC; 1.
DR   PIRSF; PIRSF003159; FlhC; 1.
PE   3: Inferred from homology;
KW   Activator; Bacterial flagellum biogenesis; Cytoplasm; DNA-binding;
KW   Metal-binding; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..193
FT                   /note="Flagellar transcriptional regulator FlhC"
FT                   /id="PRO_0000064346"
FT   BINDING         138
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT   BINDING         141
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT   BINDING         158
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
FT   BINDING         161
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01891"
SQ   SEQUENCE   193 AA;  21724 MW;  EAD1E0AAFF6A1A3C CRC64;
     MVEKSIVQEA KDIHLAMELI TLGARLQMLE SETQLSRGRL IKLYKELRGS PPPKGMLPFS
     TDWFMTWEQN IHSSMFYNAY SFLLKSGQCT GVEAVIKAYR LYLEQCPDQS GIPPLLALTR
     AWTLVRFVDS GMLQLSGCNC CGGTFITHAH QPRNSFVCSL CQPPSRAVKK RKLSPQSADI
     TSQLLDEQVR RAV