FLHD_CUPNH
ID FLHD_CUPNH Reviewed; 105 AA.
AC Q0K4N8;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Flagellar transcriptional regulator FlhD {ECO:0000255|HAMAP-Rule:MF_00725};
GN Name=flhD {ECO:0000255|HAMAP-Rule:MF_00725}; OrderedLocusNames=H16_B0235;
OS Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS / H16 / Stanier 337) (Ralstonia eutropha).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=381666;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337;
RX PubMed=16964242; DOI=10.1038/nbt1244;
RA Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I.,
RA Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT eutropha H16.";
RL Nat. Biotechnol. 24:1257-1262(2006).
CC -!- FUNCTION: Functions in complex with FlhC as a master transcriptional
CC regulator that regulates transcription of several flagellar and non-
CC flagellar operons by binding to their promoter region. Activates
CC expression of class 2 flagellar genes, including fliA, which is a
CC flagellum-specific sigma factor that turns on the class 3 genes. Also
CC regulates genes whose products function in a variety of physiological
CC pathways. {ECO:0000255|HAMAP-Rule:MF_00725}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. Forms a heterohexamer composed of
CC two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming
CC a heterotrimer, and a hexamer assembles by dimerization of two
CC heterotrimers. {ECO:0000255|HAMAP-Rule:MF_00725}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00725}.
CC -!- DOMAIN: The C-terminal region contains a putative helix-turn-helix
CC (HTH) motif, suggesting that this region may bind DNA.
CC {ECO:0000255|HAMAP-Rule:MF_00725}.
CC -!- SIMILARITY: Belongs to the FlhD family. {ECO:0000255|HAMAP-
CC Rule:MF_00725}.
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DR EMBL; AM260480; CAJ95036.1; -; Genomic_DNA.
DR RefSeq; WP_010812713.1; NZ_CP039288.1.
DR AlphaFoldDB; Q0K4N8; -.
DR SMR; Q0K4N8; -.
DR STRING; 381666.H16_B0235; -.
DR EnsemblBacteria; CAJ95036; CAJ95036; H16_B0235.
DR GeneID; 57646114; -.
DR KEGG; reh:H16_B0235; -.
DR eggNOG; ENOG5031P80; Bacteria.
DR HOGENOM; CLU_144160_1_0_4; -.
DR OMA; REDKPMG; -.
DR OrthoDB; 2022460at2; -.
DR Proteomes; UP000008210; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:1902208; P:regulation of bacterial-type flagellum assembly; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.4000.10; -; 1.
DR HAMAP; MF_00725; FlhD; 1.
DR InterPro; IPR023559; Flagellar_FlhD.
DR InterPro; IPR036194; FlhD_sf.
DR Pfam; PF05247; FlhD; 1.
DR SUPFAM; SSF63592; SSF63592; 1.
PE 3: Inferred from homology;
KW Activator; Bacterial flagellum biogenesis; Cytoplasm; Disulfide bond;
KW DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..105
FT /note="Flagellar transcriptional regulator FlhD"
FT /id="PRO_1000045885"
FT DISULFID 65
FT /note="Interchain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00725"
SQ SEQUENCE 105 AA; 11827 MW; 32044C5A5899D6DD CRC64;
MESSEVLQEI REVNLAYLLL AQRLVRENQV EAMFRLGVSK EIADILAKLT SAQLVKLAAS
NMVLCRFRFD DHALLSTLTH TAKSHDMQQI HAAILLARQP VESLN
