ID   FLHD_ECO57              Reviewed;         116 AA.
AC   Q8XCE8;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   07-NOV-2003, sequence version 2.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Flagellar transcriptional regulator FlhD {ECO:0000255|HAMAP-Rule:MF_00725};
GN   Name=flhD {ECO:0000255|HAMAP-Rule:MF_00725};
GN   OrderedLocusNames=Z2946, ECs2602;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Functions in complex with FlhC as a master transcriptional
CC       regulator that regulates transcription of several flagellar and non-
CC       flagellar operons by binding to their promoter region. Activates
CC       expression of class 2 flagellar genes, including fliA, which is a
CC       flagellum-specific sigma factor that turns on the class 3 genes. Also
CC       regulates genes whose products function in a variety of physiological
CC       pathways. {ECO:0000255|HAMAP-Rule:MF_00725}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. Forms a heterohexamer composed of
CC       two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming
CC       a heterotrimer, and a hexamer assembles by dimerization of two
CC       heterotrimers. {ECO:0000255|HAMAP-Rule:MF_00725}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00725}.
CC   -!- DOMAIN: The C-terminal region contains a putative helix-turn-helix
CC       (HTH) motif, suggesting that this region may bind DNA.
CC       {ECO:0000255|HAMAP-Rule:MF_00725}.
CC   -!- SIMILARITY: Belongs to the FlhD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00725}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG56882.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAB36025.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE005174; AAG56882.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BA000007; BAB36025.1; ALT_INIT; Genomic_DNA.
DR   PIR; B90954; B90954.
DR   PIR; F85802; F85802.
DR   RefSeq; NP_310629.2; NC_002695.1.
DR   RefSeq; WP_001302091.1; NZ_SEKU01000012.1.
DR   AlphaFoldDB; Q8XCE8; -.
DR   SMR; Q8XCE8; -.
DR   STRING; 155864.EDL933_2867; -.
DR   EnsemblBacteria; AAG56882; AAG56882; Z2946.
DR   EnsemblBacteria; BAB36025; BAB36025; ECs_2602.
DR   GeneID; 913958; -.
DR   KEGG; ece:Z2946; -.
DR   KEGG; ecs:ECs_2602; -.
DR   PATRIC; fig|386585.9.peg.2728; -.
DR   eggNOG; ENOG5031P80; Bacteria.
DR   HOGENOM; CLU_144160_0_0_6; -.
DR   OMA; REDKPMG; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:1902208; P:regulation of bacterial-type flagellum assembly; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.4000.10; -; 1.
DR   HAMAP; MF_00725; FlhD; 1.
DR   InterPro; IPR023559; Flagellar_FlhD.
DR   InterPro; IPR036194; FlhD_sf.
DR   Pfam; PF05247; FlhD; 1.
DR   SUPFAM; SSF63592; SSF63592; 1.
PE   3: Inferred from homology;
KW   Activator; Bacterial flagellum biogenesis; Cytoplasm; Disulfide bond;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..116
FT                   /note="Flagellar transcriptional regulator FlhD"
FT                   /id="PRO_0000182715"
FT   DISULFID        65
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00725"
SQ   SEQUENCE   116 AA;  13301 MW;  D31A3E239E9A4C06 CRC64;
     MHTSELLKHI YDINLSYLLL AQRLIVQDKA SAMFRLGINE EMATTLAALT LPQMVKLAET
     NQLVCHFRFD SHQTITLLTQ DSRVDDLQQI HTGIMLSTRL LNDVNQPEEA LRKKRA