FLHD_SALTY
ID FLHD_SALTY Reviewed; 113 AA.
AC P0A2R2; O52221;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Flagellar transcriptional regulator FlhD {ECO:0000255|HAMAP-Rule:MF_00725};
GN Name=flhD {ECO:0000255|HAMAP-Rule:MF_00725}; OrderedLocusNames=STM1925;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RA Toguchi A., Harshey R.M.;
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10586519; DOI=10.1266/ggs.74.105;
RA Yanagihara S., Iyoda S., Ohnishi K., Iino T., Kutsukake K.;
RT "Structure and transcriptional control of the flagellar master operon of
RT Salmonella typhimurium.";
RL Genes Genet. Syst. 74:105-111(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [4]
RP INTERACTION WITH YDIV, DNA-BINDING, AND INDUCTION.
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=21278297; DOI=10.1128/jb.01494-10;
RA Wada T., Morizane T., Abo T., Tominaga A., Inoue-Tanaka K., Kutsukake K.;
RT "EAL domain protein YdiV acts as an anti-FlhD4C2 factor responsible for
RT nutritional control of the flagellar regulon in Salmonella enterica Serovar
RT Typhimurium.";
RL J. Bacteriol. 193:1600-1611(2011).
CC -!- FUNCTION: Functions in complex with FlhC as a master transcriptional
CC regulator that regulates transcription of several flagellar and non-
CC flagellar operons by binding to their promoter region. Activates
CC expression of class 2 flagellar genes, including fliA, which is a
CC flagellum-specific sigma factor that turns on the class 3 genes. Also
CC regulates genes whose products function in a variety of physiological
CC pathways (Probable). {ECO:0000305}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. Forms a heterohexamer composed of
CC two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming
CC a heterotrimer, and a hexamer assembles by dimerization of two
CC heterotrimers (Probable). This subunit binds DNA and interacts with
CC YdiV, which decreases its ability to bind DNA. {ECO:0000255|HAMAP-
CC Rule:MF_00725, ECO:0000269|PubMed:21278297, ECO:0000305}.
CC -!- INTERACTION:
CC P0A2R2; Q8ZPS6: ydiV; NbExp=2; IntAct=EBI-6413853, EBI-6413835;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00725}.
CC -!- INDUCTION: 1.5-fold induced in nutrient-poor medium.
CC {ECO:0000269|PubMed:21278297}.
CC -!- DOMAIN: The C-terminal region contains a putative helix-turn-helix
CC (HTH) motif, suggesting that this region may bind DNA.
CC {ECO:0000255|HAMAP-Rule:MF_00725}.
CC -!- SIMILARITY: Belongs to the FlhD family. {ECO:0000255|HAMAP-
CC Rule:MF_00725}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB96639.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAL20841.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAA85314.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF029300; AAB96639.1; ALT_INIT; Genomic_DNA.
DR EMBL; D43640; BAA85314.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE006468; AAL20841.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_460882.1; NC_003197.2.
DR AlphaFoldDB; P0A2R2; -.
DR SMR; P0A2R2; -.
DR IntAct; P0A2R2; 1.
DR STRING; 99287.STM1925; -.
DR PaxDb; P0A2R2; -.
DR EnsemblBacteria; AAL20841; AAL20841; STM1925.
DR GeneID; 1253446; -.
DR KEGG; stm:STM1925; -.
DR PATRIC; fig|99287.12.peg.2042; -.
DR HOGENOM; CLU_144160_0_0_6; -.
DR OMA; REDKPMG; -.
DR PhylomeDB; P0A2R2; -.
DR PHI-base; PHI:7271; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:1902208; P:regulation of bacterial-type flagellum assembly; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.4000.10; -; 1.
DR HAMAP; MF_00725; FlhD; 1.
DR InterPro; IPR023559; Flagellar_FlhD.
DR InterPro; IPR036194; FlhD_sf.
DR Pfam; PF05247; FlhD; 1.
DR SUPFAM; SSF63592; SSF63592; 1.
PE 1: Evidence at protein level;
KW Activator; Bacterial flagellum biogenesis; Cytoplasm; Disulfide bond;
KW DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..113
FT /note="Flagellar transcriptional regulator FlhD"
FT /id="PRO_0000182725"
FT DISULFID 65
FT /note="Interchain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00725"
SQ SEQUENCE 113 AA; 13006 MW; 58327B10C1E385D9 CRC64;
MHTSELLKHI YDINLSYLLL AQRLIVQDKA SAMFRLGINE EMANTLGALT LPQMVKLAET
NQLVCHFRFD DHQTITRLTQ DSRVDDLQQI HTGIMLSTRL LNEVDDTARK KRA
