FLHF_HELPJ
ID FLHF_HELPJ Reviewed; 455 AA.
AC Q9ZM34;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Flagellar biosynthesis protein FlhF;
DE AltName: Full=Flagella-associated GTP-binding protein;
GN Name=flhF; OrderedLocusNames=jhp_0389;
OS Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85963;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J99 / ATCC 700824;
RX PubMed=9923682; DOI=10.1038/16495;
RA Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT "Genomic sequence comparison of two unrelated isolates of the human gastric
RT pathogen Helicobacter pylori.";
RL Nature 397:176-180(1999).
CC -!- FUNCTION: Necessary for flagellar biosynthesis. May be involved in
CC translocation of the flagellum (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GTP-binding SRP family. {ECO:0000305}.
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DR EMBL; AE001439; AAD05976.1; -; Genomic_DNA.
DR PIR; C71938; C71938.
DR RefSeq; WP_010882516.1; NZ_CP011330.1.
DR AlphaFoldDB; Q9ZM34; -.
DR SMR; Q9ZM34; -.
DR STRING; 85963.jhp_0389; -.
DR EnsemblBacteria; AAD05976; AAD05976; jhp_0389.
DR KEGG; hpj:jhp_0389; -.
DR PATRIC; fig|85963.30.peg.621; -.
DR eggNOG; COG1419; Bacteria.
DR OMA; LIQNMFW; -.
DR Proteomes; UP000000804; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR020006; FlhF.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000897; SRP54_GTPase_dom.
DR PANTHER; PTHR43134:SF3; PTHR43134:SF3; 1.
DR Pfam; PF00448; SRP54; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00962; SRP54; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR03499; FlhF; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis; Bacterial flagellum protein export;
KW Cell membrane; GTP-binding; Membrane; Nucleotide-binding;
KW Protein transport; Transport.
FT CHAIN 1..455
FT /note="Flagellar biosynthesis protein FlhF"
FT /id="PRO_0000101224"
FT BINDING 259..266
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 338..342
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 396..399
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
SQ SEQUENCE 455 AA; 51949 MW; 03CEC37D234B4565 CRC64;
MKFYTYSGET AAEALKIAQS HHGVDTLVFK TQEIRKKTLT SSGLYEIVVA VEEEENKKAP
LIPESLYDEE LNEEDVVMQL SSTVEEMRKL AGVSSNQRNY TFSKNKTLLE KDAPLEDTPL
EANKQDALLQ ALKDEANHKK EREKREVKQE EEIKDINAQL SKIRDSLKLI QNMFWDEKNP
NSVNIPQEFA EIYKLAKQSG MKSSHLDEIM QLSLELMPLR MRENSVTIKR YFREVLRKII
LCRPEDLNLR QKRILMLVGP TGVGKTTTLA KLAARYSRML AKKYKVGIIT LDNYRIGALE
QLSWYANKMK MSIEAVIDAK DFAKEIEALE YCDFILVDTT GHSQYDKEKI AGLKEFIDGG
YNIDVSLVLS VTTKYEDMKD IYDSFGVLGI DTLIFTKLDE SRGLGNLFSL VHESQKPISY
LSVGQEVPMD LKVATNEYLV DCMLDGFSNP NKEQA
