ID   FLHF_HELPY              Reviewed;         459 AA.
AC   O25679;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Flagellar biosynthesis protein FlhF;
DE   AltName: Full=Flagella-associated GTP-binding protein;
GN   Name=flhF; OrderedLocusNames=HP_1035;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- FUNCTION: Necessary for flagellar biosynthesis. May be involved in
CC       translocation of the flagellum (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GTP-binding SRP family. {ECO:0000305}.
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DR   EMBL; AE000511; AAD08078.1; -; Genomic_DNA.
DR   PIR; C64649; C64649.
DR   RefSeq; NP_207825.1; NC_000915.1.
DR   RefSeq; WP_000238399.1; NC_018939.1.
DR   AlphaFoldDB; O25679; -.
DR   SMR; O25679; -.
DR   DIP; DIP-3259N; -.
DR   IntAct; O25679; 8.
DR   MINT; O25679; -.
DR   STRING; 85962.C694_05355; -.
DR   PaxDb; O25679; -.
DR   EnsemblBacteria; AAD08078; AAD08078; HP_1035.
DR   KEGG; hpy:HP_1035; -.
DR   PATRIC; fig|85962.8.peg.1084; -.
DR   eggNOG; COG1419; Bacteria.
DR   OMA; LIQNMFW; -.
DR   PhylomeDB; O25679; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0005047; F:signal recognition particle binding; IBA:GO_Central.
DR   GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR   GO; GO:0006605; P:protein targeting; IBA:GO_Central.
DR   GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR020006; FlhF.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000897; SRP54_GTPase_dom.
DR   PANTHER; PTHR43134:SF3; PTHR43134:SF3; 1.
DR   Pfam; PF00448; SRP54; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00962; SRP54; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03499; FlhF; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum biogenesis; Bacterial flagellum protein export;
KW   Cell membrane; GTP-binding; Membrane; Nucleotide-binding;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..459
FT                   /note="Flagellar biosynthesis protein FlhF"
FT                   /id="PRO_0000101223"
FT   BINDING         263..270
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         342..346
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         400..403
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   459 AA;  52302 MW;  4C6B513BCC43E815 CRC64;
     MVKFYTYSGE TAAEALKIAQ SHHGVDTLVF KTQEIRKKTL TSSGLYEIVV AVEEESENKP
     SKAPLIPESL YDEELNEEDV VMQLSSTVEE MRKLAGVSSS QRHYSFSKNK TLLEKDAPLE
     DAPLEANKQD ALLQALKDEA NHKKEREKRE VKQEEEIKDI NLQLSKIRDS LKLIQNMFWD
     EKNPNSINIP QEFAEIYKLA KQSGMKPSHL DEIMQLSLEL MPLRMRENSV TIKRYFREVL
     RKMILCCPED LNLRQKRILM LVGPTGVGKT TTLAKLAARY SRMLAKKYKV GIITLDNYRI
     GALEQLSWYA NKMKMSIEAV IDAKDFAKEI EALEYCDFIL VDTTGHSQYD KEKIAGLKEF
     IDGGYNIDVS LVLSVTTKYE DMKDIYDSFG VLGIDTLIFT KLDESRGLGN LFSLVHESQK
     PISYLSVGQE VPMDLKVATN EYLVDCMLDG FSNPNKEQA