ID   FLHF_TREPA              Reviewed;         437 AA.
AC   Q56339;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Flagellar biosynthesis protein FlhF;
DE   AltName: Full=Flagella-associated GTP-binding protein;
GN   Name=flhF; OrderedLocusNames=TP_0713;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9063647; DOI=10.3109/10425179709020157;
RA   Hardham J.M., Frye J.G., Young N.R., Stamm L.V.;
RT   "Identification and sequences of the Treponema pallidum flhA, flhF, and
RT   orf304 genes.";
RL   DNA Seq. 7:107-116(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- FUNCTION: Necessary for flagellar biosynthesis. May be involved in
CC       translocation of the flagellum (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GTP-binding SRP family. {ECO:0000305}.
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DR   EMBL; U36839; AAB00551.1; -; Genomic_DNA.
DR   EMBL; AE000520; AAC65679.1; -; Genomic_DNA.
DR   PIR; E71290; E71290.
DR   RefSeq; WP_010882158.1; NC_021490.2.
DR   AlphaFoldDB; Q56339; -.
DR   SMR; Q56339; -.
DR   IntAct; Q56339; 3.
DR   STRING; 243276.TPANIC_0713; -.
DR   EnsemblBacteria; AAC65679; AAC65679; TP_0713.
DR   GeneID; 57879238; -.
DR   KEGG; tpa:TP_0713; -.
DR   eggNOG; COG1419; Bacteria.
DR   HOGENOM; CLU_009301_11_4_12; -.
DR   OMA; WYEVDEY; -.
DR   OrthoDB; 1162441at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR   GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR020006; FlhF.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000897; SRP54_GTPase_dom.
DR   PANTHER; PTHR43134:SF3; PTHR43134:SF3; 1.
DR   Pfam; PF00448; SRP54; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00962; SRP54; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR03499; FlhF; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum biogenesis; Bacterial flagellum protein export;
KW   Cell membrane; GTP-binding; Membrane; Nucleotide-binding;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..437
FT                   /note="Flagellar biosynthesis protein FlhF"
FT                   /id="PRO_0000101226"
FT   BINDING         224..231
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         308..312
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         368..371
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   437 AA;  49284 MW;  FBDFA22D4599BED0 CRC64;
     MELLVEVAPT KEKAIEKIRK KYGDRVNILR TQRNNRSFFF GLIERVSVEI FFSVNSGSQS
     SVHEIPSVQS RTRVSAARVE DTEAEKIKIL ESAQRINAKI AQQVEPLISA AKEKKTEKVP
     TSPEAVHALT QTLEGMIQKI TNSAPVVIAQ ELQSIQRIEL LLEENDFSFS FIRKSIARLK
     DELSYHDLES FEKVESTVLR WIIESVHIQV PPICTGTRNI VLVGPTGVGK TTTLAKLAAF
     YFVTEPKRTG IQPRVKIITT DNFRIGAAFQ MERYCELMGL DLCVVQAPVE FLTYMTLYQQ
     ETDVVFVDTE GRSPVDGQNI ERMVEYFRAV KNFELEVYLT IDAGSKANDL REVFKQYALF
     EYRALIVTKL DETTSIGNLI SALSEARTPI TYITTGQTVP SNLEKASVNL LLSKLKGFKL
     LAEEMGNDYG DYGSKER