ID   FLI1_XENLA              Reviewed;         453 AA.
AC   P41157;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Retroviral integration site protein Fli-1 homolog;
GN   Name=fli1; Synonyms=fli;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8155576; DOI=10.1016/0925-4773(93)90061-2;
RA   Meyer D., Wolff C.M., Stiegler P., Senan F., Befort N., Befort J.J.,
RA   Remy P.;
RT   "Xl-fli, the Xenopus homologue of the fli-1 gene, is expressed during
RT   embryogenesis in a restricted pattern evocative of neural crest cell
RT   distribution.";
RL   Mech. Dev. 44:109-121(1993).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR   EMBL; X66979; CAA47389.1; -; mRNA.
DR   PIR; S49013; S49013.
DR   RefSeq; NP_001084371.1; NM_001090902.1.
DR   AlphaFoldDB; P41157; -.
DR   BMRB; P41157; -.
DR   SMR; P41157; -.
DR   GeneID; 399466; -.
DR   KEGG; xla:399466; -.
DR   CTD; 399466; -.
DR   Xenbase; XB-GENE-6253886; fli1.S.
DR   OrthoDB; 1113327at2759; -.
DR   Proteomes; UP000186698; Chromosome 7S.
DR   Bgee; 399466; Expressed in lung and 14 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd08541; SAM_PNT-FLI-1; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR035575; Fli-1.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR035573; SAM_PNT-FLI-1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; PTHR11849; 1.
DR   PANTHER; PTHR11849:SF161; PTHR11849:SF161; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..453
FT                   /note="Retroviral integration site protein Fli-1 homolog"
FT                   /id="PRO_0000204126"
FT   DOMAIN          111..197
FT                   /note="PNT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT   DNA_BIND        282..362
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT   REGION          201..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        228..273
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   453 AA;  51016 MW;  A6E6FCC60EC42DA4 CRC64;
     MDGTIKEALS VVSDDQSLFD SAYGASSHLS KADMTASANP DYGQPHKINP IPPQQDWINQ
     PMRVNIKREY EHMNGSRESP VDCSINKCSK LIGGSEGNAM TYTYMDEKNG PPPPNMTTNE
     RRVIVPADPA LWSQDHVRQW LEWAIKEYGL VEIDCSLFQN IDGKELCKMS KEDFLRSTSI
     YNTEVLLSHL NYLRDSSSSL GYNTQAHTDQ SSRLTAKEDP SYEAVRRSGW GNSMSSPVTK
     SPPMGGTQNV NKSGDQQRSQ PDPYQILGPT SSRLANPGSG QIQLWQFLLE LLSDSSNASC
     ITWEGTNGEF KMTDPDEVAR RWGERKSKPN MNYDKLSRAL RYYYDKSIMT KVHGKRYAYK
     FDFHGIAQAL QPHPTDTSMY KYPSEFSYMP SYHSHQQKVN FVPSHPSSMP VTSSGFFGAT
     SPYWNSPSAN IYPNPNVPRH PNTHVQSHLG GFY