ID   FLIC_BRUME              Reviewed;         282 AA.
AC   Q8YDM5;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Flagellin;
GN   Name=fliC; OrderedLocusNames=BMEII0150;
OS   Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=224914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=16M / ATCC 23456 / NCTC 10094;
RX   PubMed=11756688; DOI=10.1073/pnas.221575398;
RA   DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA   Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA   Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA   Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA   Haselkorn R., Kyrpides N.C., Overbeek R.;
RT   "The genome sequence of the facultative intracellular pathogen Brucella
RT   melitensis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
RN   [2]
RP   FUNCTION IN INFECTION PERSISTENCE, EXPRESSION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=16M / ATCC 23456 / NCTC 10094;
RX   PubMed=15839898; DOI=10.1111/j.1462-5822.2005.00502.x;
RA   Fretin D., Fauconnier A., Koehler S., Halling S., Leonard S., Nijskens C.,
RA   Ferooz J., Lestrate P., Delrue R.-M., Danese I., Vandenhaute J., Tibor A.,
RA   DeBolle X., Letesson J.-J.;
RT   "The sheathed flagellum of Brucella melitensis is involved in persistence
RT   in a murine model of infection.";
RL   Cell. Microbiol. 7:687-698(2005).
CC   -!- FUNCTION: Flagellin is the subunit protein which polymerizes to form
CC       the filaments of bacterial flagella (By similarity). The flagellum is
CC       required to cause a persistent disease in a murine model of infection.
CC       {ECO:0000250, ECO:0000269|PubMed:15839898}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Bacterial flagellum.
CC   -!- INDUCTION: Expressed at the onset of the exponential phase (after 4, 8
CC       and 12 hours of culture) but not at later time points.
CC   -!- DISRUPTION PHENOTYPE: A fliC mutant is attenuated in a murine model of
CC       infection. As the infection progresses, the number of cfu per spleen
CC       from mice infected with the mutant is significantly lower than the
CC       number from mice infected with the wild-type.
CC       {ECO:0000269|PubMed:15839898}.
CC   -!- SIMILARITY: Belongs to the bacterial flagellin family. {ECO:0000305}.
CC   -!- CAUTION: Despite the presence of a stop codon in position 243 in the
CC       fliF gene and in position 127 in the flhA gene, it has been shown that
CC       B.melitensis is able to express genes corresponding to the M ring, the
CC       hook and the filament of the flagellar apparatus in the early log phase
CC       of growth in 2YT broth. Under these conditions, a polar and sheathed
CC       flagellar structure is visible by transmission electron microscopy.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE008918; AAL53391.1; -; Genomic_DNA.
DR   PIR; AD3528; AD3528.
DR   RefSeq; WP_004681009.1; NZ_GG703779.1.
DR   AlphaFoldDB; Q8YDM5; -.
DR   SMR; Q8YDM5; -.
DR   STRING; 224914.BMEII0150; -.
DR   EnsemblBacteria; AAL53391; AAL53391; BMEII0150.
DR   GeneID; 29595008; -.
DR   KEGG; bme:BMEII0150; -.
DR   PATRIC; fig|224914.52.peg.3240; -.
DR   eggNOG; COG1344; Bacteria.
DR   OMA; ENEKRMN; -.
DR   PhylomeDB; Q8YDM5; -.
DR   Proteomes; UP000000419; Chromosome II.
DR   GO; GO:0009288; C:bacterial-type flagellum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR001492; Flagellin.
DR   InterPro; IPR046358; Flagellin_C.
DR   InterPro; IPR001029; Flagellin_N.
DR   PANTHER; PTHR42792; PTHR42792; 1.
DR   Pfam; PF00700; Flagellin_C; 1.
DR   Pfam; PF00669; Flagellin_N; 1.
DR   PRINTS; PR00207; FLAGELLIN.
PE   1: Evidence at protein level;
KW   Bacterial flagellum; Secreted.
FT   CHAIN           1..282
FT                   /note="Flagellin"
FT                   /id="PRO_0000323998"
SQ   SEQUENCE   282 AA;  29069 MW;  DF645A110EC1D4B0 CRC64;
     MASILTNSSA LTALQTLAST NKSLESTQNR ISTGLRISEA SDNASYWSIA TSMKSDNKAN
     SAVQDALGLG AGKVDTAYSA INKIRESVDD IKTKLVSAMG ASTEDKGKIE TEIKSIVANI
     NSALSNANYA GSNLLNGPTT DLNVVASYNR SGNAVAVDKI TVKATDTDAK TMVKDIVDAG
     FFTSASDDTA IGTALNTVET ALASLATGAA TLGAAKSQID SQKSFLSGLQ DSIEKGVGTL
     VDADMNKESA RLSALQVQQQ LGVQALSIAN SSNQSILSLF RG