FLIC_ECOLI
ID FLIC_ECOLI Reviewed; 498 AA.
AC P04949;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Flagellin;
GN Name=fliC; Synonyms=flaF, hag; OrderedLocusNames=b1923, JW1908;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=3536885; DOI=10.1128/jb.168.3.1479-1483.1986;
RA Kuwajima G., Asaka J., Fujiwara T., Fujiwara T., Node K., Kondo E.;
RT "Nucleotide sequence of the hag gene encoding flagellin of Escherichia
RT coli.";
RL J. Bacteriol. 168:1479-1483(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=2659972; DOI=10.1007/bf00332229;
RA Hanafusa T., Sakai A., Tominaga A., Enomoto M.;
RT "Isolation and characterization of Escherichia coli hag operator mutants
RT whose hag48 expression has become repressible by a Salmonella H1
RT repressor.";
RL Mol. Gen. Genet. 216:44-50(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y.,
RA Horiuchi T.;
RT "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 40.1-50.0 min region on the linkage map.";
RL DNA Res. 3:379-392(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
RX PubMed=6305924; DOI=10.1128/jb.155.1.74-81.1983;
RA Szekely E., Simon M.;
RT "DNA sequence adjacent to flagellar genes and evolution of flagellar-phase
RT variation.";
RL J. Bacteriol. 155:74-81(1983).
RN [7]
RP PROTEIN SEQUENCE OF 2-13.
RC STRAIN=K12 / EMG2;
RX PubMed=9298646; DOI=10.1002/elps.1150180807;
RA Link A.J., Robison K., Church G.M.;
RT "Comparing the predicted and observed properties of proteins encoded in the
RT genome of Escherichia coli K-12.";
RL Electrophoresis 18:1259-1313(1997).
RN [8]
RP PROTEIN SEQUENCE OF 2-5.
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9600841; DOI=10.1006/jmbi.1998.1726;
RA Wilkins M.R., Gasteiger E., Tonella L., Ou K., Tyler M., Sanchez J.-C.,
RA Gooley A.A., Walsh B.J., Bairoch A., Appel R.D., Williams K.L.,
RA Hochstrasser D.F.;
RT "Protein identification with N and C-terminal sequence tags in proteome
RT projects.";
RL J. Mol. Biol. 278:599-608(1998).
CC -!- FUNCTION: Flagellin is the subunit protein which polymerizes to form
CC the filaments of bacterial flagella.
CC -!- INTERACTION:
CC P04949; Q29XT7: etpA; Xeno; NbExp=5; IntAct=EBI-1112859, EBI-15745451;
CC -!- SUBCELLULAR LOCATION: Secreted. Bacterial flagellum.
CC -!- SIMILARITY: Belongs to the bacterial flagellin family. {ECO:0000305}.
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DR EMBL; M14358; AAA23950.1; -; Genomic_DNA.
DR EMBL; X17440; CAA35488.1; -; Genomic_DNA.
DR EMBL; U00096; AAC74990.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA15751.1; -; Genomic_DNA.
DR EMBL; J01607; AAA92491.1; -; Genomic_DNA.
DR PIR; A37249; FLEC.
DR RefSeq; NP_416433.1; NC_000913.3.
DR RefSeq; WP_000079739.1; NZ_LN832404.1.
DR AlphaFoldDB; P04949; -.
DR SMR; P04949; -.
DR BioGRID; 4259658; 13.
DR DIP; DIP-9649N; -.
DR IntAct; P04949; 12.
DR STRING; 511145.b1923; -.
DR SWISS-2DPAGE; P04949; -.
DR PaxDb; P04949; -.
DR PRIDE; P04949; -.
DR EnsemblBacteria; AAC74990; AAC74990; b1923.
DR EnsemblBacteria; BAA15751; BAA15751; BAA15751.
DR GeneID; 949101; -.
DR KEGG; ecj:JW1908; -.
DR KEGG; eco:b1923; -.
DR PATRIC; fig|1411691.4.peg.326; -.
DR EchoBASE; EB0317; -.
DR eggNOG; COG1344; Bacteria.
DR HOGENOM; CLU_011142_7_2_6; -.
DR InParanoid; P04949; -.
DR OMA; IASQTTY; -.
DR PhylomeDB; P04949; -.
DR BioCyc; EcoCyc:EG10321-MON; -.
DR Reactome; R-HSA-168176; Toll Like Receptor 5 (TLR5) Cascade.
DR Reactome; R-HSA-5602680; MyD88 deficiency (TLR5).
DR Reactome; R-HSA-5603037; IRAK4 deficiency (TLR5).
DR Reactome; R-HSA-975871; MyD88 cascade initiated on plasma membrane.
DR PRO; PR:P04949; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0009288; C:bacterial-type flagellum; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 6.10.10.10; -; 1.
DR InterPro; IPR001492; Flagellin.
DR InterPro; IPR046358; Flagellin_C.
DR InterPro; IPR042187; Flagellin_C_sub2.
DR InterPro; IPR014981; Flagellin_D3.
DR InterPro; IPR001029; Flagellin_N.
DR PANTHER; PTHR42792; PTHR42792; 1.
DR Pfam; PF00700; Flagellin_C; 1.
DR Pfam; PF08884; Flagellin_D3; 1.
DR Pfam; PF00669; Flagellin_N; 1.
DR PRINTS; PR00207; FLAGELLIN.
PE 1: Evidence at protein level;
KW Bacterial flagellum; Direct protein sequencing; Reference proteome;
KW Secreted.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:9298646,
FT ECO:0000269|PubMed:9600841"
FT CHAIN 2..498
FT /note="Flagellin"
FT /id="PRO_0000182560"
FT CONFLICT 285
FT /note="P -> L (in Ref. 2; CAA35488)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 498 AA; 51295 MW; 14A0ED3E68E326A1 CRC64;
MAQVINTNSL SLITQNNINK NQSALSSSIE RLSSGLRINS AKDDAAGQAI ANRFTSNIKG
LTQAARNAND GISVAQTTEG ALSEINNNLQ RVRELTVQAT TGTNSESDLS SIQDEIKSRL
DEIDRVSGQT QFNGVNVLAK NGSMKIQVGA NDNQTITIDL KQIDAKTLGL DGFSVKNNDT
VTTSAPVTAF GATTTNNIKL TGITLSTEAA TDTGGTNPAS IEGVYTDNGN DYYAKITGGD
NDGKYYAVTV ANDGTVTMAT GATANATVTD ANTTKATTIT SGGTPVQIDN TAGSATANLG
AVSLVKLQDS KGNDTDTYAL KDTNGNLYAA DVNETTGAVS VKTITYTDSS GAASSPTAVK
LGGDDGKTEV VDIDGKTYDS ADLNGGNLQT GLTAGGEALT AVANGKTTDP LKALDDAIAS
VDKFRSSLGA VQNRLDSAVT NLNNTTTNLS EAQSRIQDAD YATEVSNMSK AQIIQQAGNS
VLAKANQVPQ QVLSLLQG
