ID   FLID1_PSEAI             Reviewed;         478 AA.
AC   O33421; Q51456; Q9LAG5; Q9LAG6;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=A-type flagellar hook-associated protein 2;
DE            Short=HAP2;
DE   AltName: Full=Filament cap protein;
DE   AltName: Full=Flagellar cap protein;
GN   Name=fliD;
OS   Pseudomonas aeruginosa.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=PAK;
RX   PubMed=9488388; DOI=10.1128/iai.66.3.1000-1007.1998;
RA   Arora S.K., Ritchings B.W., Almira E.C., Lory S., Ramphal R.;
RT   "The Pseudomonas aeruginosa flagellar cap protein, FliD, is responsible for
RT   mucin adhesion.";
RL   Infect. Immun. 66:1000-1007(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 29260 / PA103, CS2, CS32, and PAK;
RX   PubMed=10678962; DOI=10.1128/iai.68.3.1474-1479.2000;
RA   Arora S.K., Dasgupta N., Lory S., Ramphal R.;
RT   "Identification of two distinct types of flagellar cap proteins, FliD, in
RT   Pseudomonas aeruginosa.";
RL   Infect. Immun. 68:1474-1479(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 347-478.
RC   STRAIN=DG1;
RA   Wahl S.A., Darzins A., Baker N.R.;
RL   Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the morphogenesis and for the elongation of the
CC       flagellar filament by facilitating polymerization of the flagellin
CC       monomers at the tip of growing filament. Forms a capping structure,
CC       which prevents flagellin subunits (transported through the central
CC       channel of the flagellum) from leaking out without polymerization at
CC       the distal end. Essential for motility. Responsible for adhesion to
CC       mucin, which is the initial event in colonization by this organism of
CC       the airways of cystic fibrosis patients. {ECO:0000269|PubMed:9488388}.
CC   -!- SUBUNIT: Homopentamer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Bacterial flagellum.
CC   -!- SIMILARITY: Belongs to the FliD family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L81176; AAC09391.1; -; Genomic_DNA.
DR   EMBL; AF139824; AAF35981.1; -; Genomic_DNA.
DR   EMBL; AF139823; AAF35979.1; -; Genomic_DNA.
DR   EMBL; AF139825; AAF35983.1; -; Genomic_DNA.
DR   EMBL; AF139822; AAF35977.1; -; Genomic_DNA.
DR   EMBL; L43064; AAA99299.1; -; Genomic_DNA.
DR   RefSeq; WP_003123161.1; NZ_WXZX01000001.1.
DR   RefSeq; WP_043083576.1; NZ_WCHW01000009.1.
DR   AlphaFoldDB; O33421; -.
DR   SMR; O33421; -.
DR   PATRIC; fig|287.1479.peg.3135; -.
DR   eggNOG; COG1345; Bacteria.
DR   GO; GO:0009421; C:bacterial-type flagellum filament cap; IEA:InterPro.
DR   GO; GO:0009424; C:bacterial-type flagellum hook; IEA:InterPro.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   InterPro; IPR010810; Flagellin_hook_IN_motif.
DR   InterPro; IPR040026; FliD.
DR   InterPro; IPR010809; FliD_C.
DR   InterPro; IPR003481; FliD_N.
DR   PANTHER; PTHR30288; PTHR30288; 1.
DR   Pfam; PF07196; Flagellin_IN; 1.
DR   Pfam; PF07195; FliD_C; 1.
DR   Pfam; PF02465; FliD_N; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum; Coiled coil; Secreted.
FT   CHAIN           1..478
FT                   /note="A-type flagellar hook-associated protein 2"
FT                   /id="PRO_0000177021"
FT   COILED          409..460
FT                   /evidence="ECO:0000255"
FT   VARIANT         166
FT                   /note="T -> S (in strain: PA103 and CS32)"
FT   VARIANT         235
FT                   /note="K -> R (in strain: PA103)"
FT   VARIANT         347..352
FT                   /note="TDVRML -> DLQACV (in strain: DG1)"
FT   VARIANT         430
FT                   /note="E -> Q (in strain: PA103 and CS32)"
FT   VARIANT         433
FT                   /note="N -> D (in strain: PA103)"
SQ   SEQUENCE   478 AA;  50705 MW;  A54C1FBCF9AE6579 CRC64;
     MANSTTINGY NSGLDIKNIV STLVAAEKAP KEAQLKRLES DTTAKFTGIG QLKSAISDLQ
     TILKELNKPE LFQKRSASTS DEKFATATAT KDALPGIYKL EVTQLASVSK VATASFADGY
     KTTSGGTLTI KQGADDAGVT VNVAAGATLA EVRDSLNAQL KDKGITANIV NNPGDGTSRL
     VFTGKDSGAG KDVFVQGSSG LENFNIGSVG ADGKLTLSQL DGTSSSSSGY ITQAKNAKFS
     IDGLTLESPT NTVDKVINGV TFELKTVTDT NKPITISVEQ DRGGVKDNIK KFVEAYNKLV
     GVTSELTGVT KVGDDKAPVV GALVGDSSVR NLLTTMRNEM VQPGQGTDVR MLADMGITTK
     KDGTLEIDDK KLDKVLKDKF ESVSALFTGD TGLMKRLDDK LTPYTQTGGV LQQRLDGLQD
     TIKSVDTQRE ALNRRVEQLQ DRLLKQFTAM DQLIGQLNQT SGRMAQALSS LPGLVKKS