ID   FLIDP_VIBPA             Reviewed;         670 AA.
AC   Q56705;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2003, sequence version 2.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Polar flagellar hook-associated protein 2;
DE            Short=HAP2;
DE   AltName: Full=Filament cap protein;
DE   AltName: Full=Flagellar cap protein;
GN   Name=fliDP; Synonyms=flaH; OrderedLocusNames=VP2256;
OS   Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=223926;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BB22;
RX   PubMed=7883718; DOI=10.1128/jb.177.6.1595-1609.1995;
RA   McCarter L.L.;
RT   "Genetic and molecular characterization of the polar flagellum of Vibrio
RT   parahaemolyticus.";
RL   J. Bacteriol. 177:1595-1609(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RIMD 2210633;
RX   PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA   Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA   Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA   Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT   "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT   distinct from that of V. cholerae.";
RL   Lancet 361:743-749(2003).
CC   -!- FUNCTION: Required for the morphogenesis and for the elongation of the
CC       flagellar filament by facilitating polymerization of the flagellin
CC       monomers at the tip of growing filament. Forms a capping structure,
CC       which prevents flagellin subunits (transported through the central
CC       channel of the flagellum) from leaking out without polymerization at
CC       the distal end. Important for swimming motility.
CC   -!- SUBUNIT: Homopentamer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Bacterial flagellum.
CC   -!- MISCELLANEOUS: V.parahaemolyticus possesses two flagellar systems: a
CC       single polar flagellum propels the bacterium in liquid (swimming),
CC       while multiple lateral (peritrichous) flagella move the bacterium over
CC       surfaces (swarming). The polar flagellum is synthesized constitutively
CC       but lateral flagella are produced only under conditions in which the
CC       polar flagellum is not functional.
CC   -!- SIMILARITY: Belongs to the FliD family. {ECO:0000305}.
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DR   EMBL; AF069392; AAC27803.1; -; Genomic_DNA.
DR   EMBL; BA000031; BAC60519.1; -; Genomic_DNA.
DR   PIR; S71032; S71032.
DR   RefSeq; NP_798635.1; NC_004603.1.
DR   RefSeq; WP_005481075.1; NC_004603.1.
DR   AlphaFoldDB; Q56705; -.
DR   STRING; 223926.28807249; -.
DR   EnsemblBacteria; BAC60519; BAC60519; BAC60519.
DR   GeneID; 1189769; -.
DR   KEGG; vpa:VP2256; -.
DR   PATRIC; fig|223926.6.peg.2159; -.
DR   eggNOG; COG1345; Bacteria.
DR   HOGENOM; CLU_015182_2_0_6; -.
DR   OMA; FIGAYNE; -.
DR   Proteomes; UP000002493; Chromosome 1.
DR   GO; GO:0009421; C:bacterial-type flagellum filament cap; IEA:InterPro.
DR   GO; GO:0009424; C:bacterial-type flagellum hook; IEA:InterPro.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   InterPro; IPR010810; Flagellin_hook_IN_motif.
DR   InterPro; IPR040026; FliD.
DR   InterPro; IPR010809; FliD_C.
DR   InterPro; IPR003481; FliD_N.
DR   PANTHER; PTHR30288; PTHR30288; 1.
DR   Pfam; PF07196; Flagellin_IN; 1.
DR   Pfam; PF07195; FliD_C; 1.
DR   Pfam; PF02465; FliD_N; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum; Coiled coil; Reference proteome; Secreted.
FT   CHAIN           1..670
FT                   /note="Polar flagellar hook-associated protein 2"
FT                   /id="PRO_0000177030"
FT   REGION          226..300
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          342..428
FT                   /evidence="ECO:0000255"
FT   CONFLICT        260
FT                   /note="D -> G (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        262..265
FT                   /note="Missing (in Ref. 1)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   670 AA;  73249 MW;  B3A7CDDB3B23F663 CRC64;
     MSLGPVGMSG GMDINSMVSK IVDAERVPKQ QRIDNDRTTI NASISAYGRL RESLDTMKNL
     MANFRQEKAF AVRTVETTDD NIVSATATTD AIAGKYAIDV LQLAQSHKVA SDVLPEDAKF
     GPGKLQISLG DDRFNIEVRS RSKLIDVVRG INGAKDNPGV RASVINDVEG PRLILASNLS
     GKDHQIKVSV EAERGNPLKY FEYQTLEDRV NALEEARAAA EEVLGPLQAP QQPDQPEILD
     ENGNPLPPEA QKAADNAQDD AQDDASQEPI SAAGAEAAKA GQEAIDKANQ RSSLRPEERI
     PGWTETASGT LLDSYEEPEL ELDEKAIEKA PDVPGWNNAA SGTLTDSYVT TKEAKQLLEQ
     EKAEIEQKIA DEKQELDAKV ERGELSEEQA KQIHRAKLDP QERERLEKID EAEAKIAKAQ
     SSFEEYLGMT EVQAGQDSEV LLDGVAKLSS HNNVIEDAIE GVDLTLKGKS EPNKPPAEIG
     VEYDRQSVRS DIENFVSAYN SFYQTSQALS SVDPTTGQKG PLAGDSTVRS ADSRLKAVFS
     SRIDQAPENL KSLTEFGITT TRQGTLEINY DMLDRQLNNN FNELEKFFGG NTGFAKRIED
     AIHGITGITG SIRTREKSLT EQNYRLNDDQ AALDRRMEGL EKRTHAKFTA MQDATGKMQG
     QLGALMSALG