ID   FLID_HELPJ              Reviewed;         685 AA.
AC   Q9ZL91;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Flagellar hook-associated protein 2;
DE            Short=HAP2;
DE   AltName: Full=Filament cap protein;
DE   AltName: Full=Flagellar cap protein;
GN   Name=fliD; OrderedLocusNames=jhp_0689;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- FUNCTION: Required for the morphogenesis and for the elongation of the
CC       flagellar filament by facilitating polymerization of the flagellin
CC       monomers at the tip of growing filament. Forms a capping structure,
CC       which prevents flagellin subunits (transported through the central
CC       channel of the flagellum) from leaking out without polymerization at
CC       the distal end. Essential to colonize and establish infection in
CC       gastric mucosa as a result of its essential role in motility (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homopentamer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Bacterial flagellum.
CC   -!- SIMILARITY: Belongs to the FliD family. {ECO:0000305}.
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DR   EMBL; AE001439; AAD06264.1; -; Genomic_DNA.
DR   PIR; A71901; A71901.
DR   RefSeq; WP_010882551.1; NZ_CP011330.1.
DR   AlphaFoldDB; Q9ZL91; -.
DR   SMR; Q9ZL91; -.
DR   STRING; 85963.jhp_0689; -.
DR   EnsemblBacteria; AAD06264; AAD06264; jhp_0689.
DR   KEGG; hpj:jhp_0689; -.
DR   PATRIC; fig|85963.30.peg.290; -.
DR   eggNOG; COG1345; Bacteria.
DR   OMA; IMAERFA; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0009421; C:bacterial-type flagellum filament cap; IEA:InterPro.
DR   GO; GO:0009424; C:bacterial-type flagellum hook; IEA:InterPro.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   InterPro; IPR040026; FliD.
DR   InterPro; IPR010809; FliD_C.
DR   InterPro; IPR003481; FliD_N.
DR   PANTHER; PTHR30288; PTHR30288; 1.
DR   Pfam; PF07195; FliD_C; 1.
DR   Pfam; PF02465; FliD_N; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum; Coiled coil; Secreted.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..685
FT                   /note="Flagellar hook-associated protein 2"
FT                   /id="PRO_0000177020"
FT   COILED          618..647
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   685 AA;  74119 MW;  6CCD640B64252C12 CRC64;
     MAIGSLSSLG LGSKVLNYDV IDKLKDADEK ALIAPLDKKM EQNVEKQKAL VEIKTLLSSL
     KGPVKTLSDY STYISRKSNV TGDALSASVG AGVPIQDIKV DVQNLAQGDI NELGAKFSSR
     DDIFSQVDTT LKFYTQNKDY AVDIKAGMTL GDVAQSITDA TNGEVMGIVM KTGGNDPYQL
     MVNTKNTGED NRVYFGSHLQ STLTNKNALS LGLDGAGKSE LSLNLKGADG SMHEVPIMLE
     LPESASIKQK NAAIQKAMEQ ALENDPNFKD LIANGDISID TLHGGESLII NDRRGGNIEV
     KGSKAKELGF SQTTTQESDL LKSARTIKEG KLEGVVSLNG QKLDLSALTK ESNTSEENTD
     AIIQAINAKE GLNAFKNAEG KLVINSKTGM LTIKGEDALG KASLKDLGLS AGMVQSYEAS
     QDTLFMSKNL QKASDSQFTY NGVSITRPTN EVNDVISGVN ITLEQTTEPN KPAIISVSRD
     NQAIIDSLKE FVKAYNELIP KLDEDTRYDA DTKIAGIFNG VGDIRAIRSS LNNVFSYSVH
     TDNGVESLMK YGLSLDDKGV MSLDEAKLSS ALNSNPKATQ DFFYGSDSKD MGGREIHQEG
     IFSKFNQVIA NLIDGGNAKL KIYEDSLDRD AKSLTKDKEN AQELLKTRYN IMAERFAAYD
     SQISKANQKF NSVQMMIDQA AAKKN