ID   FLID_TREPA              Reviewed;         722 AA.
AC   O83842;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Flagellar hook-associated protein 2;
DE            Short=HAP2;
DE   AltName: Full=Filament cap protein;
DE   AltName: Full=Flagellar cap protein;
GN   Name=fliD; OrderedLocusNames=TP_0872;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- FUNCTION: Required for the morphogenesis and for the elongation of the
CC       flagellar filament by facilitating polymerization of the flagellin
CC       monomers at the tip of growing filament. Forms a capping structure,
CC       which prevents flagellin subunits (transported through the central
CC       channel of the flagellum) from leaking out without polymerization at
CC       the distal end (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homopentamer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasmic flagellum. Periplasm.
CC   -!- SIMILARITY: Belongs to the FliD family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000520; AAC65836.1; -; Genomic_DNA.
DR   PIR; F71270; F71270.
DR   RefSeq; WP_010882315.1; NC_021490.2.
DR   AlphaFoldDB; O83842; -.
DR   SMR; O83842; -.
DR   IntAct; O83842; 1.
DR   STRING; 243276.TPANIC_0872; -.
DR   EnsemblBacteria; AAC65836; AAC65836; TP_0872.
DR   KEGG; tpa:TP_0872; -.
DR   eggNOG; COG0373; Bacteria.
DR   eggNOG; COG1345; Bacteria.
DR   HOGENOM; CLU_028399_0_0_12; -.
DR   OMA; FIGAYNE; -.
DR   OrthoDB; 883503at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0009421; C:bacterial-type flagellum filament cap; IEA:InterPro.
DR   GO; GO:0009424; C:bacterial-type flagellum hook; IEA:InterPro.
DR   GO; GO:0055040; C:periplasmic flagellum; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   InterPro; IPR040026; FliD.
DR   InterPro; IPR010809; FliD_C.
DR   InterPro; IPR003481; FliD_N.
DR   PANTHER; PTHR30288; PTHR30288; 1.
DR   Pfam; PF07195; FliD_C; 1.
DR   Pfam; PF02465; FliD_N; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum; Coiled coil; Periplasm; Reference proteome.
FT   CHAIN           1..722
FT                   /note="Flagellar hook-associated protein 2"
FT                   /id="PRO_0000177027"
FT   REGION          251..299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          311..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          660..710
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        260..278
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..366
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   722 AA;  78400 MW;  E2AEEAD06348B0BC CRC64;
     MSDVRIPGVG AGKYDNLIQS LMKKERIPRD NAAAKVKVYE VQNNALKDVE RYARDLRDAV
     KGLYSFNNPF AEKEAHSSNE RAFTVDATRD AAEQNHTLRV KDIAQGDAFL SDPLPEDFRV
     PSGTYTFCIG EKKICVSWKG GHYRDFIRAV NKQGKDSLTL SEIKTSGASR ALLFRSELTG
     KSSRLSFEDA ALDLALRLRV VQEARSDVFT QDVLSVGPGK HARLDFPHPL RAQAGLTLEF
     VASLEGASIA NEESRAHTPA QGGAPTSSHG NTASAAHNQD GAAAVRPTEP ANGAPVQEET
     SSVFFEGVTV KNEASQGDLP TTDGLEKYPA VDDKGDNPRA PGESQGTATH EGSGSSTDNA
     DDTRSTGALA GSGKLALESL QGHALPLPPL VLTQNAPQMV SIPLREYGDV RALILDNAQA
     RGALTLRAIR VRAEDAPGGY VPVNPASQAQ DAAFDFDGVH VTRGTNSITD LIPGVTLSLH
     ERTEKTETLS VTPDVNAMKN AIIEFVAKYN RLMAEINIVT SNKSAIIDEL AYLTPEEKKK
     ETEQLGSLHG DSTLLMLKDR LRRNTSNAYR AGDDGASRTL AHIGISTKAH ASSGINTAQL
     RGYLEIDEEK LHSSLNAQKD QVRALFGHDS DGDLLVDNGV AFTLTELLNP YLGRSGIFAI
     RSNGVDERIK STEKRVETYD KQLEKKEREL RHKYHTMDGA LRSLQKQSDA IQNFNQSVRN
     RN