ID   AKTPB_XENLA             Reviewed;         292 AA.
AC   Q5XGV8;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=AKT-interacting protein homolog B;
GN   Name=aktip-b; Synonyms=aktip, fts-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function to promote vesicle trafficking and/or fusion.
CC       May also regulate apoptosis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. FTS
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00388}.
CC   -!- CAUTION: Lacks the conserved Cys residue necessary for ubiquitin-
CC       conjugating enzyme E2 activity. {ECO:0000305}.
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DR   EMBL; BC084320; AAH84320.1; -; mRNA.
DR   RefSeq; NP_001088292.1; NM_001094823.1.
DR   AlphaFoldDB; Q5XGV8; -.
DR   SMR; Q5XGV8; -.
DR   DNASU; 495128; -.
DR   GeneID; 495128; -.
DR   KEGG; xla:495128; -.
DR   CTD; 495128; -.
DR   Xenbase; XB-GENE-5735853; aktip.S.
DR   OMA; QVLKYMQ; -.
DR   OrthoDB; 1226125at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 495128; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0070695; C:FHF complex; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0045022; P:early endosome to late endosome transport; ISS:UniProtKB.
DR   GO; GO:0007032; P:endosome organization; ISS:UniProtKB.
DR   GO; GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.
DR   GO; GO:0007040; P:lysosome organization; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.110.10; -; 1.
DR   InterPro; IPR000608; UBQ-conjugat_E2.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   Pfam; PF00179; UQ_con; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
DR   PROSITE; PS50127; UBC_2; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cell membrane; Cytoplasm; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..292
FT                   /note="AKT-interacting protein homolog B"
FT                   /id="PRO_0000379023"
FT   DOMAIN          75..223
FT                   /note="UBC core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00388"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..42
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   292 AA;  33269 MW;  8F4F24A0C2765338 CRC64;
     MNPFWNMPSA SVRKRSDNDE KIATADQKIS PARSSSAKKQ LPSIPKNAVP ITKPISPPLS
     VQSTNGTHAS YGPFYLEYSL LAEFTLVVKQ KLPGVYVQPS YSSALMWFGV IFIRHGLYQD
     GVFKFTVYIP DNYPDGECPR LVFDIPVFHP LVDPISGELD VKRAFTKWRR NHNHIWQVLM
     YARRIFYKID TTSPLNPEAA VLYEKDVQLF KSKVVDSVKL CNSHLFDKPK IEDPYAIIFS
     PWNPVLHDDA RERMLAQKKS EEQSRGLHVS GLSWVKPGSV LPFSKEENSL QT