ID   AKTR2_ALTAL             Reviewed;         435 AA.
AC   Q9P4U8;
DT   18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Transcription activator AKTR-2 {ECO:0000303|PubMed:10975654};
DE   AltName: Full=AK-toxin biosynthesis regulator 2 {ECO:0000303|PubMed:10975654};
GN   Name=AKTR-2 {ECO:0000303|PubMed:10975654};
OS   Alternaria alternata (Alternaria rot fungus) (Torula alternata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Alternaria;
OC   Alternaria sect. Alternaria; Alternaria alternata complex.
OX   NCBI_TaxID=5599;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=15A;
RX   PubMed=10975654; DOI=10.1094/mpmi.2000.13.9.975;
RA   Tanaka A., Tsuge T.;
RT   "Structural and functional complexity of the genomic region controlling AK-
RT   toxin biosynthesis and pathogenicity in the Japanese pear pathotype of
RT   Alternaria alternata.";
RL   Mol. Plant Microbe Interact. 13:975-986(2000).
RN   [2]
RP   REVIEW ON HOST-SELECTIVE TOXINS.
RX   PubMed=22846083; DOI=10.1111/j.1574-6976.2012.00350.x;
RA   Tsuge T., Harimoto Y., Akimitsu K., Ohtani K., Kodama M., Akagi Y.,
RA   Egusa M., Yamamoto M., Otani H.;
RT   "Host-selective toxins produced by the plant pathogenic fungus Alternaria
RT   alternata.";
RL   FEMS Microbiol. Rev. 37:44-66(2013).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene clusters that mediate the biosynthesis of the host-selective
CC       toxins (HSTs) AK-toxins responsible for Japanese pear black spot
CC       disease by the Japanese pear pathotype (Probable). AK-toxins are esters
CC       of 9,10-epoxy 8-hydroxy 9-methyldecatrienoic acid (EDA)
CC       (PubMed:22846083). On cellular level, AK-toxins affect plasma membrane
CC       of susceptible cells and cause a sudden increase in loss of K(+) after
CC       a few minutes of toxin treatment (PubMed:22846083).
CC       {ECO:0000303|PubMed:22846083, ECO:0000305|PubMed:10975654}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- MISCELLANEOUS: Gene clusters encoding host-selective toxins (HSTs) are
CC       localized on conditionally dispensable chromosomes (CDCs), also called
CC       supernumerary chromosomes, where they are present in multiple copies
CC       (PubMed:10975654). The CDCs are not essential for saprophytic growth
CC       but controls host-selective pathogenicity (PubMed:10975654).
CC       {ECO:0000269|PubMed:10975654}.
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DR   EMBL; AB035493; BAB07812.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9P4U8; -.
DR   SMR; Q9P4U8; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..435
FT                   /note="Transcription activator AKTR-2"
FT                   /id="PRO_0000444842"
FT   DNA_BIND        16..43
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          49..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..89
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   435 AA;  48235 MW;  AAD028C78F51A1C9 CRC64;
     MLQCAPKKNE RLRGSCDFCT QSKLRCNKNK PSCRRCTIQQ QVCVYSVARR TGRPPKHPRR
     ADDSQETSGQ HGHQDPMTSA PADSCEQQSS HLDLEGDDTD FTLVDGRTTA EGRATVAPPV
     LDNAFLMGET FEFNSLLDDP LVQSEDIFSF SPHIPRGEKG VHMASFHALN ESTSPCSPSA
     LLSIDVPQLP TNFRFLESFI GSELHGRNEP HPVEQPDEME KTYDKGSILL GLDSAINAIT
     NNGKDEPSIS GWTVARPHSK HLCFCSMSMS KLQVLVSHPA LCRQNSRTPF DMVLFLEEFV
     FGIHSDVLRC LICQSRSLHS LASLCICTDW VVEALVDVAQ DLSLGQDNLG GLRAEICPPK
     NGSSIYVGRL ILADQFRESC TRSLVKYRLR KLIPIMDTMI KLNYRGAGGA LSQAIRTMVE
     DVRHKIESAL GMMEL