ID   FLIF_CAUVC              Reviewed;         536 AA.
AC   Q04954;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Flagellar M-ring protein;
GN   Name=fliF; Synonyms=flaO; OrderedLocusNames=CC_0905;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=8002583; DOI=10.1128/jb.176.24.7587-7600.1994;
RA   Ramakrishnan G., Zhao J.L., Newton A.;
RT   "Multiple structural proteins are required for both transcriptional
RT   activation and negative autoregulation of Caulobacter crescentus flagellar
RT   genes.";
RL   J. Bacteriol. 176:7587-7600(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC   -!- FUNCTION: The M ring may be actively involved in energy transduction.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The basal body constitutes a major portion of the flagellar
CC       organelle and consists of five rings (E,L,P,S, and M) mounted on a
CC       central rod. The M ring is integral to the inner membrane of the cell
CC       and may be connected to the flagellar rod via the S ring. The S
CC       (supramembrane ring) lies just distal to the M ring. The L and P rings
CC       lie in the outer membrane and the periplasmic space, respectively (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Bacterial flagellum basal body
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FliF family. {ECO:0000305}.
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DR   EMBL; M98855; AAA66325.1; -; Genomic_DNA.
DR   EMBL; AE005673; AAK22889.1; -; Genomic_DNA.
DR   PIR; A55544; A55544.
DR   AlphaFoldDB; Q04954; -.
DR   SMR; Q04954; -.
DR   STRING; 190650.CC_0905; -.
DR   PRIDE; Q04954; -.
DR   EnsemblBacteria; AAK22889; AAK22889; CC_0905.
DR   KEGG; ccr:CC_0905; -.
DR   eggNOG; COG1766; Bacteria.
DR   HOGENOM; CLU_028108_4_1_5; -.
DR   OMA; WMEPQRE; -.
DR   BioCyc; CAULO:CC0905-MON; -.
DR   Proteomes; UP000001816; Chromosome.
DR   GO; GO:0009431; C:bacterial-type flagellum basal body, MS ring; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003774; F:cytoskeletal motor activity; IEA:InterPro.
DR   GO; GO:0071973; P:bacterial-type flagellum-dependent cell motility; IEA:InterPro.
DR   Gene3D; 3.30.300.30; -; 1.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR013556; Flag_M-ring_C.
DR   InterPro; IPR000067; FlgMring_FliF.
DR   InterPro; IPR006182; FliF_N_dom.
DR   InterPro; IPR043427; YscJ/FliF.
DR   PANTHER; PTHR30046; PTHR30046; 1.
DR   PANTHER; PTHR30046:SF0; PTHR30046:SF0; 1.
DR   Pfam; PF01514; YscJ_FliF; 1.
DR   Pfam; PF08345; YscJ_FliF_C; 1.
DR   PIRSF; PIRSF004862; FliF; 1.
DR   PRINTS; PR01009; FLGMRINGFLIF.
DR   TIGRFAMs; TIGR00206; fliF; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..536
FT                   /note="Flagellar M-ring protein"
FT                   /id="PRO_0000180881"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          247..300
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        260..281
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   536 AA;  56856 MW;  058B65B175A8E032 CRC64;
     MLGVGAGVVA VLVALVMFMG KEPSELLYSN LDLKEASEVT QALDQAGIKY ETKGDGSTIM
     VPRDKVASAR LMVAGKGLVS SGSIGYEIFD TNNALGQTDF VQQLNRQRAL QGELERTIKA
     MQGVNSVRVH LVLPKRQLFE EDAEQPSAAV TIGVGSREPS SDMVRAIQNL VSSSVPNMKA
     EKVAVIDQHG KTLSAPSDES LAGKMAQDRK SEVEARIAKT VKDMIEGVLG PGKARVNVTA
     ELDLNRVTTQ EERFDPDGQV IRSESTTEAS SQENKNDDNA GVTAAANVPG GQGANGFQQL
     GSRTGQNDAV TNYEISKSVT TTVQEPGTIK KIAVAVAIDG VSAPMAADGK PGAYTPRTAQ
     EIQQIEELVK TAVGFDAERG DQVRVTNIKF PQPEDQGLEE QGLLAGFDKN DIMRAAELGV
     LAVVALLILL FAVRPFIKNL SAPAPGQIAL AGPSGGPPVT RLVTLADGTQ QQVVVDQSGE
     PIALAGPPVS DIDQRIDIAK IEGQVKASSI KRVSEFVEKH PDESVAILRN WLHEST