ID   FLIF_TREPA              Reviewed;         567 AA.
AC   O83414;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Flagellar M-ring protein;
GN   Name=fliF; OrderedLocusNames=TP_0399;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- FUNCTION: The M ring may be actively involved in energy transduction.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The basal body constitutes a major portion of the flagellar
CC       organelle and consists of five rings (E,L,P,S, and M) mounted on a
CC       central rod. The M ring is integral to the inner membrane of the cell
CC       and may be connected to the flagellar rod via the S ring. The S
CC       (supramembrane ring) lies just distal to the M ring. The L and P rings
CC       lie in the outer membrane and the periplasmic space, respectively (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Bacterial flagellum basal body
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FliF family. {ECO:0000305}.
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DR   EMBL; AE000520; AAC65387.1; -; Genomic_DNA.
DR   PIR; F71328; F71328.
DR   RefSeq; WP_010881847.1; NC_021490.2.
DR   AlphaFoldDB; O83414; -.
DR   SMR; O83414; -.
DR   IntAct; O83414; 6.
DR   STRING; 243276.TPANIC_0399; -.
DR   PRIDE; O83414; -.
DR   EnsemblBacteria; AAC65387; AAC65387; TP_0399.
DR   GeneID; 57878925; -.
DR   KEGG; tpa:TP_0399; -.
DR   eggNOG; COG1766; Bacteria.
DR   HOGENOM; CLU_028108_2_0_12; -.
DR   OMA; NYEVNRI; -.
DR   OrthoDB; 167675at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0009431; C:bacterial-type flagellum basal body, MS ring; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003774; F:cytoskeletal motor activity; IEA:InterPro.
DR   GO; GO:0071973; P:bacterial-type flagellum-dependent cell motility; IEA:InterPro.
DR   Gene3D; 3.30.300.30; -; 1.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR013556; Flag_M-ring_C.
DR   InterPro; IPR000067; FlgMring_FliF.
DR   InterPro; IPR006182; FliF_N_dom.
DR   InterPro; IPR043427; YscJ/FliF.
DR   PANTHER; PTHR30046; PTHR30046; 1.
DR   PANTHER; PTHR30046:SF0; PTHR30046:SF0; 1.
DR   Pfam; PF01514; YscJ_FliF; 1.
DR   Pfam; PF08345; YscJ_FliF_C; 1.
DR   PRINTS; PR01009; FLGMRINGFLIF.
DR   TIGRFAMs; TIGR00206; fliF; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..567
FT                   /note="Flagellar M-ring protein"
FT                   /id="PRO_0000180887"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        469..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          320..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   567 AA;  64639 MW;  16344A3FB94281EE CRC64;
     MGEWLGQLGV KLKTQWKKWT LVQKSVLAGA ALVSVMGVVV LLTWSAKPTL VPLIDTPITD
     ETVREKIILR LNEENVRATV SSVGLISVSD EKTARRMRSI LIREDLIPKN VDPWAIFDVE
     RWTRTDFERR VDVRRAINNT VTNHIKALDD IDDAHVVINV PEDALFQADQ KPITASVVIF
     PKPSSTIASE RKKIEGIQKL LKLAVPGLKD ENITIVDSDA TVLNDFEGFK DADRLSLIEK
     QQKMIAKLES QYEAKVLALL QKTYGKDRVR DLNIKIEMDL SEKTSQTTKY LPIEIRQDNP
     DTPWDDSQVV PSVTSISETA TTTWQGTGLN PEGPPGVEGQ TPPAYKDMSN QVGLSNQSVV
     KKQEAISKSE INEVVSPVLG RRTVSVNIDG EWRKKRDEHG RFIVKEGHIE REYIPISAEE
     LREATKAVQD AIGFDAGRKD SVSVLNIKFD RTSEFDREDE HYLRVQQRNM IILYSLASVA
     IVLFIFMVYK VISKEVERRR RLREEELLRQ QQLMRERALW EAEQAGMNVS MSVEERKRLE
     LQENVLNMAR EHPEDVALLV RTWLMEE