ID   FLIG_ECOL6              Reviewed;         331 AA.
AC   P0ABZ2; P31067; P76915;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Flagellar motor switch protein FliG;
GN   Name=fliG; OrderedLocusNames=c2355;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: FliG is one of three proteins (FliG, FliN, FliM) that forms
CC       the rotor-mounted switch complex (C ring), located at the base of the
CC       basal body. This complex interacts with the CheY and CheZ chemotaxis
CC       proteins, in addition to contacting components of the motor that
CC       determine the direction of flagellar rotation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC       Bacterial flagellum basal body {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FliG family. {ECO:0000305}.
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DR   EMBL; AE014075; AAN80814.1; -; Genomic_DNA.
DR   RefSeq; WP_000067950.1; NC_004431.1.
DR   AlphaFoldDB; P0ABZ2; -.
DR   SMR; P0ABZ2; -.
DR   STRING; 199310.c2355; -.
DR   EnsemblBacteria; AAN80814; AAN80814; c2355.
DR   GeneID; 66674171; -.
DR   KEGG; ecc:c2355; -.
DR   eggNOG; COG1536; Bacteria.
DR   HOGENOM; CLU_047835_2_0_6; -.
DR   OMA; QVRPFEF; -.
DR   BioCyc; ECOL199310:C2355-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0009425; C:bacterial-type flagellum basal body; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003774; F:cytoskeletal motor activity; IEA:InterPro.
DR   GO; GO:0071973; P:bacterial-type flagellum-dependent cell motility; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   InterPro; IPR000090; Flg_Motor_Flig.
DR   InterPro; IPR023087; Flg_Motor_Flig_C.
DR   InterPro; IPR011002; FliG_a-hlx.
DR   InterPro; IPR032779; FliG_M.
DR   InterPro; IPR028263; FliG_N.
DR   PANTHER; PTHR30534; PTHR30534; 1.
DR   Pfam; PF01706; FliG_C; 1.
DR   Pfam; PF14841; FliG_M; 1.
DR   Pfam; PF14842; FliG_N; 1.
DR   PIRSF; PIRSF003161; FliG; 1.
DR   PRINTS; PR00954; FLGMOTORFLIG.
DR   SUPFAM; SSF48029; SSF48029; 2.
DR   TIGRFAMs; TIGR00207; fliG; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum; Cell inner membrane; Cell membrane; Chemotaxis;
KW   Flagellar rotation; Membrane.
FT   CHAIN           1..331
FT                   /note="Flagellar motor switch protein FliG"
FT                   /id="PRO_0000184091"
FT   MOTIF           125..128
FT                   /note="Part of the EHPQR-motif"
FT   SITE            160
FT                   /note="Part of the EHPQR-motif"
SQ   SEQUENCE   331 AA;  36776 MW;  E5CB4C0415C6E178 CRC64;
     MSNLTGTDKS VILLMTIGED RAAEVFKHLS QREVQTLSAA MANVTQISNK QLTDVLAEFE
     QEAEQFAALN INANDYLRSV LVKALGEERA ASLLEDILET RDTASGIETL NFMEPQSAAD
     LIRDEHPQII ATILVHLKRA QAADILALFD ERLRHDVMLR IATFGGVQPA ALAELTEVLN
     GLLDGQNLKR SKMGGVRTAA EIINLMKTQQ EEAVITAVRE FDGELAQKII DEMFLFENLV
     DVDDRSIQRL LQEVDSESLL IALKGAEQPL REKFLRNMSQ RAADILRDDL ANRGPVRLSQ
     VENEQKAILL IVRRLAETGE MVIGSGEDTY V