AK_CHLPN
ID AK_CHLPN Reviewed; 440 AA.
AC Q9Z6L0; Q9JQD3; Q9K1X9;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Aspartokinase;
DE EC=2.7.2.4;
DE AltName: Full=Aspartate kinase;
GN Name=lysC; OrderedLocusNames=CPn_1049, CP_0803, CpB1090;
OS Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=83558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-aspartate = 4-phospho-L-aspartate + ADP;
CC Xref=Rhea:RHEA:23776, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57535, ChEBI:CHEBI:456216; EC=2.7.2.4;
CC -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo
CC pathway; L-homoserine from L-aspartate: step 1/3.
CC -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine
CC from L-aspartate: step 1/5.
CC -!- SIMILARITY: Belongs to the aspartokinase family. {ECO:0000305}.
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DR EMBL; AE001363; AAD19186.1; -; Genomic_DNA.
DR EMBL; AE002161; AAF38602.1; -; Genomic_DNA.
DR EMBL; BA000008; BAA99256.1; -; Genomic_DNA.
DR EMBL; AE009440; AAP99019.1; -; Genomic_DNA.
DR PIR; F86621; F86621.
DR PIR; G81537; G81537.
DR PIR; H72002; H72002.
DR RefSeq; NP_225243.1; NC_000922.1.
DR RefSeq; WP_010883682.1; NZ_LN847257.1.
DR AlphaFoldDB; Q9Z6L0; -.
DR SMR; Q9Z6L0; -.
DR STRING; 115711.CP_0803; -.
DR EnsemblBacteria; AAD19186; AAD19186; CPn_1049.
DR EnsemblBacteria; AAF38602; AAF38602; CP_0803.
DR GeneID; 45051107; -.
DR KEGG; cpa:CP_0803; -.
DR KEGG; cpj:lysC; -.
DR KEGG; cpn:CPn_1049; -.
DR KEGG; cpt:CpB1090; -.
DR PATRIC; fig|115713.3.peg.1148; -.
DR eggNOG; COG0527; Bacteria.
DR HOGENOM; CLU_009116_6_0_0; -.
DR OrthoDB; 1067792at2; -.
DR UniPathway; UPA00034; UER00015.
DR UniPathway; UPA00050; UER00461.
DR UniPathway; UPA00051; UER00462.
DR Proteomes; UP000000583; Chromosome.
DR Proteomes; UP000000801; Chromosome.
DR GO; GO:0004072; F:aspartate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019877; P:diaminopimelate biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.20.120.1320; -; 1.
DR Gene3D; 3.40.1160.10; -; 1.
DR InterPro; IPR036393; AceGlu_kinase-like_sf.
DR InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR InterPro; IPR005260; Asp_kin_monofn.
DR InterPro; IPR001341; Asp_kinase.
DR InterPro; IPR042199; AsparK_Bifunc_asparK/hSer_DH.
DR InterPro; IPR018042; Aspartate_kinase_CS.
DR Pfam; PF00696; AA_kinase; 1.
DR PIRSF; PIRSF000726; Asp_kin; 1.
DR SUPFAM; SSF53633; SSF53633; 1.
DR TIGRFAMs; TIGR00657; asp_kinases; 1.
DR PROSITE; PS00324; ASPARTOKINASE; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; ATP-binding; Diaminopimelate biosynthesis; Kinase;
KW Lysine biosynthesis; Nucleotide-binding; Transferase.
FT CHAIN 1..440
FT /note="Aspartokinase"
FT /id="PRO_0000066674"
FT CONFLICT 145
FT /note="R -> S (in Ref. 2; AAF38602)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 440 AA; 48382 MW; 28E11BE300BAB959 CRC64;
MSKIVYKFGG TSLATAENIC LVCDIICKDK PSFVVVSAIA GVTDLLVDFC SSSLREREEV
LRKIEGKHEE IVKNLAIPFP VSTWTSRLLP YLQHLEISDL DFARILSLGE DISASLVRAV
CSTRGWDLGF LEARSVILTD DSYRRASPNL DLMKAHWHQL ELNQPSYIIQ GFIGSNGLGE
TVLLGRGGSD YSATLIAELA RATEVRIYTD VNGIYTMDPK VISDAQRIPE LSFEEMQNLA
SFGAKVLYPP MLFPCMRAGI PIFVTSTFDP EKGGTWVYAV DKSVSYEPRI KALSLSQYQS
FCSVDYTVLG CGGLEEILGI LESHGIDPEL MIAQNNVVGF VMDDDIISQE AQEHLVDVLS
LSSVTRLHHS VALITMIGDN LSSPKVVSTI TEKLRGFQGP VFCFCQSSMA LSFVVASELA
EGIIEELHND YVKQKAIVAT
