ID   FLIG_VIBCH              Reviewed;         348 AA.
AC   Q9X4Q9; Q7DCT8;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Flagellar motor switch protein FliG;
GN   Name=fliG; OrderedLocusNames=VC_2132;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RA   Hase C.C., Mekalanos J.J.;
RT   "Deletion in the fliG gene of Vibrio cholerae result in non-motile
RT   bacteria.";
RL   Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: FliG is one of three proteins (FliG, FliN, FliM) that forms
CC       the rotor-mounted switch complex (C ring), located at the base of the
CC       basal body. This complex interacts with the CheY and CheZ chemotaxis
CC       proteins, in addition to contacting components of the motor that
CC       determine the direction of flagellar rotation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC       Bacterial flagellum basal body {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FliG family. {ECO:0000305}.
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DR   EMBL; AF117332; AAD30267.1; -; Genomic_DNA.
DR   EMBL; AE003852; AAF95277.1; -; Genomic_DNA.
DR   PIR; D82114; D82114.
DR   RefSeq; NP_231763.1; NC_002505.1.
DR   RefSeq; WP_001030089.1; NZ_LT906614.1.
DR   AlphaFoldDB; Q9X4Q9; -.
DR   SMR; Q9X4Q9; -.
DR   STRING; 243277.VC_2132; -.
DR   PRIDE; Q9X4Q9; -.
DR   DNASU; 2613388; -.
DR   EnsemblBacteria; AAF95277; AAF95277; VC_2132.
DR   GeneID; 57740751; -.
DR   GeneID; 66940022; -.
DR   KEGG; vch:VC_2132; -.
DR   PATRIC; fig|243277.26.peg.2037; -.
DR   eggNOG; COG1536; Bacteria.
DR   HOGENOM; CLU_047835_2_0_6; -.
DR   OMA; QVRPFEF; -.
DR   BioCyc; VCHO:VC2132-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0009425; C:bacterial-type flagellum basal body; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003774; F:cytoskeletal motor activity; IEA:InterPro.
DR   GO; GO:0071973; P:bacterial-type flagellum-dependent cell motility; IBA:GO_Central.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   InterPro; IPR000090; Flg_Motor_Flig.
DR   InterPro; IPR023087; Flg_Motor_Flig_C.
DR   InterPro; IPR011002; FliG_a-hlx.
DR   InterPro; IPR032779; FliG_M.
DR   InterPro; IPR028263; FliG_N.
DR   PANTHER; PTHR30534; PTHR30534; 1.
DR   Pfam; PF01706; FliG_C; 1.
DR   Pfam; PF14841; FliG_M; 1.
DR   Pfam; PF14842; FliG_N; 1.
DR   PIRSF; PIRSF003161; FliG; 1.
DR   PRINTS; PR00954; FLGMOTORFLIG.
DR   SUPFAM; SSF48029; SSF48029; 2.
DR   TIGRFAMs; TIGR00207; fliG; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum; Cell inner membrane; Cell membrane; Chemotaxis;
KW   Flagellar rotation; Membrane; Reference proteome.
FT   CHAIN           1..348
FT                   /note="Flagellar motor switch protein FliG"
FT                   /id="PRO_0000184098"
FT   MOTIF           141..144
FT                   /note="Part of the EHPQR-motif"
FT   SITE            176
FT                   /note="Part of the EHPQR-motif"
SQ   SEQUENCE   348 AA;  38157 MW;  83D7487B6B01D492 CRC64;
     MAKDNKDGGE VVESTIDISE IPGEEKAAIL LLSLNEEDAA GIIRHLEPKQ VQRVGSAMAR
     AKDLSQTKVS AVHRAFLEDI QKYTNIGMGS EDFLRNALVA ALGADKANNL VDQILLGTGS
     KGLDSLKWMD PRQVASIIIN EHPQIQTIVL SYLEPDQSAE ILAQFAQRDA LDLLMRIANL
     EEVQPSALAE LNEIMEKQFA GQAGAQAAKI GGLKAAADIM NYLDNNIESV LMEGMREKDE
     DLATQIQDLM FVFENLVEVD DQGIQKLLRD VPQDVLQKAL KGADDTLREK IFKNMSKRAA
     EMMKDDLEAM PPIKVSDVEA AQKEILSIAR RMADNGEIML GGGADEFL