AK_CHLTR
ID AK_CHLTR Reviewed; 431 AA.
AC O84367;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Aspartokinase;
DE EC=2.7.2.4;
DE AltName: Full=Aspartate kinase;
GN Name=lysC; OrderedLocusNames=CT_362;
OS Chlamydia trachomatis (strain D/UW-3/Cx).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=272561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D/UW-3/Cx;
RX PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT trachomatis.";
RL Science 282:754-759(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-aspartate = 4-phospho-L-aspartate + ADP;
CC Xref=Rhea:RHEA:23776, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57535, ChEBI:CHEBI:456216; EC=2.7.2.4;
CC -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo
CC pathway; L-homoserine from L-aspartate: step 1/3.
CC -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine
CC from L-aspartate: step 1/5.
CC -!- SIMILARITY: Belongs to the aspartokinase family. {ECO:0000305}.
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DR EMBL; AE001273; AAC67958.1; -; Genomic_DNA.
DR PIR; G71524; G71524.
DR RefSeq; NP_219871.1; NC_000117.1.
DR RefSeq; WP_010725171.1; NC_000117.1.
DR AlphaFoldDB; O84367; -.
DR SMR; O84367; -.
DR STRING; 813.O172_01985; -.
DR EnsemblBacteria; AAC67958; AAC67958; CT_362.
DR GeneID; 884754; -.
DR KEGG; ctr:CT_362; -.
DR PATRIC; fig|272561.5.peg.391; -.
DR HOGENOM; CLU_009116_6_0_0; -.
DR InParanoid; O84367; -.
DR OMA; ESVTIWK; -.
DR UniPathway; UPA00034; UER00015.
DR UniPathway; UPA00050; UER00461.
DR UniPathway; UPA00051; UER00462.
DR Proteomes; UP000000431; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0004072; F:aspartate kinase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019877; P:diaminopimelate biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0009090; P:homoserine biosynthetic process; IBA:GO_Central.
DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.20.120.1320; -; 1.
DR Gene3D; 3.40.1160.10; -; 1.
DR InterPro; IPR036393; AceGlu_kinase-like_sf.
DR InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR InterPro; IPR001341; Asp_kinase.
DR InterPro; IPR042199; AsparK_Bifunc_asparK/hSer_DH.
DR InterPro; IPR018042; Aspartate_kinase_CS.
DR Pfam; PF00696; AA_kinase; 1.
DR SUPFAM; SSF53633; SSF53633; 1.
DR TIGRFAMs; TIGR00657; asp_kinases; 1.
DR PROSITE; PS00324; ASPARTOKINASE; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; ATP-binding; Diaminopimelate biosynthesis; Kinase;
KW Lysine biosynthesis; Nucleotide-binding; Reference proteome; Transferase.
FT CHAIN 1..431
FT /note="Aspartokinase"
FT /id="PRO_0000066675"
SQ SEQUENCE 431 AA; 47648 MW; 170F9B7DB1DCC919 CRC64;
MLRQETAPLV CKFGGTSVGT AQSIRRVCEI IQEERPSFVV VSAVAGVTDW LEEFCRLPKG
KRAALTEKIR ERHESIAKEL GIEVSLAIFW EILEHFEDVE ELFSEDQARI LAIGEDLSST
LICSYCCTYV LPLKRLEARQ VILTDSQFLR AVPDLALMQT AWGELALQED TIYLMQGFLG
ATSSGKTTVL GRGGSDFSAS LIGELCKARE LRIYTDVCGV HTADPKILKD TQLIDSLTFE
EMQELASSGA KVLHQDMLKP CVRAKVPIFV TSTFNVTKEG TWICASLNES TEGPVIKALS
LKSNQALWFV EYNSPLVRLE DVLGCVRSLG FVPGVVMAQS LGVYFTIDWE EYPQTITKAL
EAFGTVSCEG PLSLVALVGA KLASWSMSRV FEALHRTPVL CWSQTDTVIN LIINKDFGVA
VTELLHDCLF K