FLII_BORBU
ID FLII_BORBU Reviewed; 436 AA.
AC P52607; Q44913; Q44916;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Flagellum-specific ATP synthase;
DE EC=7.1.2.2;
GN Name=fliI; OrderedLocusNames=BB_0288;
OS Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)
OS (Borrelia burgdorferi).
OC Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX NCBI_TaxID=224326;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RA Dunn J.J., Butler-Loffredo L., Kieleczawa J., Medalle J., Luft B.J.;
RL Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=212;
RX PubMed=8626068; DOI=10.1016/0378-1119(95)00743-1;
RA Ge Y., Old I.G., Saint-Girons I., Yelton D.B., Charon N.W.;
RT "FliH and fliI of Borrelia burgdorferi are similar to flagellar and
RT virulence factor export proteins of other bacteria.";
RL Gene 168:73-75(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=212;
RA Ge Y., Saint-Girons I., Old I.G., Charon N.W.;
RL Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX PubMed=9403685; DOI=10.1038/37551;
RA Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L.,
RA Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L.,
RA Peterson J.D., Kerlavage A.R., Quackenbush J., Salzberg S.L., Hanson M.,
RA van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F.,
RA Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C.,
RA Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B.,
RA Smith H.O., Venter J.C.;
RT "Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.";
RL Nature 390:580-586(1997).
CC -!- FUNCTION: Probable catalytic subunit of a protein translocase for
CC flagellum-specific export, or a proton translocase involved in local
CC circuits at the flagellum. May be involved in a specialized protein
CC export pathway that proceeds without signal peptide cleavage.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate;
CC Xref=Rhea:RHEA:57720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.1.2.2;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family.
CC {ECO:0000305}.
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DR EMBL; U43739; AAA85611.1; -; Genomic_DNA.
DR EMBL; L43325; AAB04681.1; -; Genomic_DNA.
DR EMBL; L76303; AAB51413.1; -; Genomic_DNA.
DR EMBL; AE000783; AAC66660.1; -; Genomic_DNA.
DR PIR; H70135; H70135.
DR RefSeq; NP_212422.1; NC_001318.1.
DR RefSeq; WP_002660657.1; NC_001318.1.
DR AlphaFoldDB; P52607; -.
DR SMR; P52607; -.
DR STRING; 224326.BB_0288; -.
DR PRIDE; P52607; -.
DR EnsemblBacteria; AAC66660; AAC66660; BB_0288.
DR KEGG; bbu:BB_0288; -.
DR PATRIC; fig|224326.49.peg.687; -.
DR HOGENOM; CLU_022398_5_1_12; -.
DR OMA; MLMMDSV; -.
DR Proteomes; UP000001807; Chromosome.
DR GO; GO:0009288; C:bacterial-type flagellum; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030257; C:type III protein secretion system complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-EC.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:UniProtKB-EC.
DR GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:InterPro.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR004100; ATPase_F1/V1/A1_a/bsu_N.
DR InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
DR InterPro; IPR005714; ATPase_T3SS_FliI/YscN.
DR InterPro; IPR022426; FliI_clade3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR040627; T3SS_ATPase_C.
DR Pfam; PF00006; ATP-synt_ab; 1.
DR Pfam; PF02874; ATP-synt_ab_N; 1.
DR Pfam; PF18269; T3SS_ATPase_C; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR03498; FliI_clade3; 1.
DR TIGRFAMs; TIGR01026; fliI_yscN; 1.
PE 3: Inferred from homology;
KW ATP synthesis; ATP-binding; Bacterial flagellum biogenesis;
KW Bacterial flagellum protein export; Cytoplasm; Hydrogen ion transport;
KW Ion transport; Nucleotide-binding; Protein transport; Reference proteome;
KW Translocase; Transport.
FT CHAIN 1..436
FT /note="Flagellum-specific ATP synthase"
FT /id="PRO_0000144689"
FT BINDING 165..172
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT CONFLICT 76
FT /note="S -> N (in Ref. 2; AAB04681 and 3; AAB51413)"
FT /evidence="ECO:0000305"
FT CONFLICT 118
FT /note="L -> F (in Ref. 2; AAB04681)"
FT /evidence="ECO:0000305"
FT CONFLICT 128
FT /note="E -> Q (in Ref. 2; AAB04681)"
FT /evidence="ECO:0000305"
FT CONFLICT 158..167
FT /note="GQRVGIFSGS -> RTKELVFFWF (in Ref. 2; AAB04681)"
FT /evidence="ECO:0000305"
FT CONFLICT 171..174
FT /note="KSTL -> NSYLC (in Ref. 2; AAB04681)"
FT /evidence="ECO:0000305"
FT CONFLICT 251
FT /note="Missing (in Ref. 2; AAB04681)"
FT /evidence="ECO:0000305"
FT CONFLICT 252..253
FT /note="LL -> FC (in Ref. 2; AAB04681 and 3; AAB51413)"
FT /evidence="ECO:0000305"
FT CONFLICT 259
FT /note="R -> W (in Ref. 2; AAB04681)"
FT /evidence="ECO:0000305"
FT CONFLICT 265..274
FT /note="REMSLSLGEP -> KRDVSFFRGA (in Ref. 2; AAB04681)"
FT /evidence="ECO:0000305"
FT CONFLICT 322
FT /note="A -> D (in Ref. 2; AAB04681)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 436 AA; 48382 MW; F97F8829E8EBFF1C CRC64;
MSNFFENYLR QVDDIETVSF VGRVQKIKGL LVESLGPQCA IGDLCLIDQR NGKKVCAEVL
GFNGPYVSLM AYEGFSGIEV GNKVYSLNKG LEINLSDELL GRVIDSLGRP IDNKGSFLNN
SYKELIFEKI NPINRSIFED QILTGVKVLD GFLPVAKGQR VGIFSGSGVG KSTLLGMIAK
NSNADVNVIA FIGERGRELN EFIEHELGEE RLKKSVLVVS TSDESPISRY KGAYVATMIA
EYFREQGKDV ALLFDSITRF ANAKREMSLS LGEPPVAKGY PPSVFVEIPI LLERSGFNGN
GGSVTGFYTV LVEGDDFTEP VADNIKAVLD GHIILDRDLF DRGIYPSINV LSSTSRSIHR
IMSLEKQKLI MKARNLLSIY KDYEDLIRTG IYLKGSNKDV DFAISKYPKI INFISQGINE
TFDFENLEDE IKEILS
