FLII_CAEEL
ID FLII_CAEEL Reviewed; 1257 AA.
AC P34268; P90739; Q17331;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Protein flightless-1 homolog;
GN Name=fli-1; ORFNames=B0523.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8248259; DOI=10.1073/pnas.90.23.11386;
RA Campbell H.D., Schimansky T., Claudianos C., Ozsarac N., Kasprzak A.B.,
RA Cotsell J.N., Young I.G., de Couet H.G., Miklos G.L.G.;
RT "The Drosophila melanogaster flightless-I gene involved in gastrulation and
RT muscle degeneration encodes gelsolin-like and leucine-rich repeat domains
RT and is conserved in Caenorhabditis elegans and humans.";
RL Proc. Natl. Acad. Sci. U.S.A. 90:11386-11390(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: May play a key role in embryonic cellularization by
CC interacting with both the cytoskeleton and other cellular components.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the villin/gelsolin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U01183; AAC03567.1; -; mRNA.
DR EMBL; FO080165; CCD61730.1; -; Genomic_DNA.
DR PIR; A88536; A88536.
DR PIR; S27783; S27783.
DR RefSeq; NP_498913.2; NM_066512.5.
DR AlphaFoldDB; P34268; -.
DR SMR; P34268; -.
DR STRING; 6239.B0523.5; -.
DR EPD; P34268; -.
DR PaxDb; P34268; -.
DR PeptideAtlas; P34268; -.
DR PRIDE; P34268; -.
DR EnsemblMetazoa; B0523.5.1; B0523.5.1; WBGene00001443.
DR GeneID; 176215; -.
DR KEGG; cel:CELE_B0523.5; -.
DR UCSC; B0523.5; c. elegans.
DR CTD; 176215; -.
DR WormBase; B0523.5; CE36522; WBGene00001443; fli-1.
DR eggNOG; KOG0444; Eukaryota.
DR GeneTree; ENSGT00940000156643; -.
DR HOGENOM; CLU_002568_1_0_1; -.
DR InParanoid; P34268; -.
DR OMA; CFHGWSA; -.
DR OrthoDB; 1376537at2759; -.
DR PhylomeDB; P34268; -.
DR PRO; PR:P34268; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00001443; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IBA:GO_Central.
DR GO; GO:0051014; P:actin filament severing; IBA:GO_Central.
DR GO; GO:0008154; P:actin polymerization or depolymerization; IBA:GO_Central.
DR GO; GO:0051016; P:barbed-end actin filament capping; IBA:GO_Central.
DR GO; GO:0030239; P:myofibril assembly; IBA:GO_Central.
DR Gene3D; 3.40.20.10; -; 6.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR029919; FliI.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007122; Villin/Gelsolin.
DR PANTHER; PTHR11977; PTHR11977; 1.
DR PANTHER; PTHR11977:SF85; PTHR11977:SF85; 1.
DR Pfam; PF00626; Gelsolin; 4.
DR Pfam; PF13855; LRR_8; 3.
DR PRINTS; PR00597; GELSOLIN.
DR SMART; SM00262; GEL; 6.
DR SMART; SM00369; LRR_TYP; 11.
DR PROSITE; PS51450; LRR; 10.
PE 2: Evidence at transcript level;
KW Developmental protein; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..1257
FT /note="Protein flightless-1 homolog"
FT /id="PRO_0000218752"
FT REPEAT 6..31
FT /note="LRR 1"
FT REPEAT 32..54
FT /note="LRR 2"
FT REPEAT 56..77
FT /note="LRR 3"
FT REPEAT 78..102
FT /note="LRR 4"
FT REPEAT 103..126
FT /note="LRR 5"
FT REPEAT 128..148
FT /note="LRR 6"
FT REPEAT 149..172
FT /note="LRR 7"
FT REPEAT 174..195
FT /note="LRR 8"
FT REPEAT 197..221
FT /note="LRR 9"
FT REPEAT 222..244
FT /note="LRR 10"
FT REPEAT 246..267
FT /note="LRR 11"
FT REPEAT 268..290
FT /note="LRR 12"
FT REPEAT 292..315
FT /note="LRR 13"
FT REPEAT 316..338
FT /note="LRR 14"
FT REPEAT 339..361
FT /note="LRR 15"
FT REPEAT 363..384
FT /note="LRR 16"
FT REPEAT 510..568
FT /note="Gelsolin-like 1"
FT REPEAT 641..681
FT /note="Gelsolin-like 2"
FT REPEAT 755..798
FT /note="Gelsolin-like 3"
FT REPEAT 1166..1206
FT /note="Gelsolin-like 4"
SQ SEQUENCE 1257 AA; 144815 MW; F3EFD79FACB07493 CRC64;
MSTGVLQFVK GIDFSGNDFS GDRFPHDVEQ MTQMTWLKLN DSKLEQVPDE LSRCANLEHL
QMAHNQLISV HGELSDLPRL RSVIVRDNNL KTAGIPTDIF RMKDLTIIDL SRNQLREVPT
NLEYAKGSIV LNLSYNNIET IPNSVCANLI DLLFLDLSNN KLDMLPPQIR RLSMLQSLKL
SNNPLNHFQL KQLPSMTSLS VLHMSNTNRT LDNIPPTLDD MHNLRDVDFS ENNLPIVPEA
LFKLRNLRKL NLSGNKIEKL NMTEGEWENL ETLNMSHNQL TVLPDCVVKL TRLTKLYAAN
NQLTFEGIPS GIGKLIQLTV LHLSYNKLEL VPEGISRCVK LQKLKLDHNR LITLPEGIHL
LPDLKVLDLH ENENLVMPPK PNDARKKLAF YNIDFSLEHQ RKIAGQMTSP SSSISSVHSG
GARQDALARR KEFIRRRKQQ ADQQSADKVI QGMSKIAGVG AALTEKQQEE EERQLEAKSA
VNWKKNIEKN RRHIDYSDIF DEDVGSDEGM WVWEIENFYP SIMDEAFHGQ FYDADAYLVL
KTTREASGQL RHAIFYWLGE HASLDKGMCS AVHAVGLRNH LNATCRTQRE EMNDETEEFL
TLFGEEIVYI EGGRTISGFY TTEKPAHLTR LYRAGVNGTA VEMEPVPLSV ESLDPRFCFL
LDAGETIWIW SGYKSRITVS NKARLFAERL NKRDRKGKSE IETCRQARCP PEFWQALTGN
PDKPQGAIVE HVPEGFVAER KKLYKVNIGM GFLELPQVEL PKGIAKQDML GSKGVFVLDS
NSDIFLWIGK KANRLLKMAG QKLVVELHQM IDRPDYAQVY RETEGEESMM FRSKFAGWDE
IVPVDYTRTS DSVQRVPDLK VIVKKDNMMR ADLAALFLER QPSMSYEESE ELMEDCNYDL
ELMESFVLEG KKFVKLPQKE FGIFYTMDCY VFLCRYAVMP EEDEEGEDEH DEDDKPEMDF
KCVVYFWQGR DASNMGWLNF TFQLQPNFEE IFKDKLEVVR MYQQQENHKF LSHFKRKFLI
KRGRRGLTKN LGGKWPELFQ MRANGSSVCN RTIQVDCQAN QLCSAFCHML RIPFKEIEED
GHRGVVYVWM GKDSDPREHE FARQVASDLV VRDDDNDFRI VEVQEGEENE EFWKVLGGKK
KYETDSSFVK HTRLFRCTNE KGYFAISEKT VDFCQDDLDD DDIMILDNGD AVFLWIGARS
SDIEAKLSYQ AAQVYHASMR MKANEKPRKF MLAVRGRESC RFRKCFHAWS KMKEPMG
