ID   FLIK_ECOLI              Reviewed;         375 AA.
AC   P52614;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Flagellar hook-length control protein;
GN   Name=fliK; Synonyms=flaE, flaR; OrderedLocusNames=b1943, JW1927;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12 / KS650;
RX   PubMed=8631687; DOI=10.1128/jb.178.10.2954-2959.1996;
RA   Kawagishi I., Homma M., Williams A.W., Macnab R.M.;
RT   "Characterization of the flagellar hook length control protein fliK of
RT   Salmonella typhimurium and Escherichia coli.";
RL   J. Bacteriol. 178:2954-2959(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA   Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA   Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA   Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA   Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA   Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y.,
RA   Horiuchi T.;
RT   "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 40.1-50.0 min region on the linkage map.";
RL   DNA Res. 3:379-392(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: Controls the length of the flagellar hook.
CC   -!- DOMAIN: Two-domain protein with the central portion of the sequence
CC       acting as a hinge or connector between the two.
CC   -!- SIMILARITY: Belongs to the FliK family. {ECO:0000305}.
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DR   EMBL; L43491; AAB06632.1; -; Genomic_DNA.
DR   EMBL; L49147; AAA82639.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC75010.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA15768.1; -; Genomic_DNA.
DR   PIR; D64958; D64958.
DR   RefSeq; NP_416453.1; NC_000913.3.
DR   RefSeq; WP_000620071.1; NZ_LN832404.1.
DR   AlphaFoldDB; P52614; -.
DR   SMR; P52614; -.
DR   BioGRID; 4260391; 6.
DR   BioGRID; 850803; 3.
DR   IntAct; P52614; 15.
DR   STRING; 511145.b1943; -.
DR   TCDB; 8.A.153.1.1; the regulator of the flagellar protein export apparatus, flik (flik) family.
DR   PaxDb; P52614; -.
DR   PRIDE; P52614; -.
DR   EnsemblBacteria; AAC75010; AAC75010; b1943.
DR   EnsemblBacteria; BAA15768; BAA15768; BAA15768.
DR   GeneID; 946449; -.
DR   KEGG; ecj:JW1927; -.
DR   KEGG; eco:b1943; -.
DR   PATRIC; fig|1411691.4.peg.308; -.
DR   EchoBASE; EB4165; -.
DR   eggNOG; COG3144; Bacteria.
DR   HOGENOM; CLU_039492_0_0_6; -.
DR   InParanoid; P52614; -.
DR   OMA; ATHEHTP; -.
DR   PhylomeDB; P52614; -.
DR   BioCyc; EcoCyc:G379-MON; -.
DR   PRO; PR:P52614; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0009424; C:bacterial-type flagellum hook; IMP:EcoliWiki.
DR   GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR   GO; GO:0071973; P:bacterial-type flagellum-dependent cell motility; IMP:EcoCyc.
DR   Gene3D; 3.30.750.140; -; 1.
DR   InterPro; IPR001635; Flag_hook_Flik.
DR   InterPro; IPR021136; Flagellar_hook_control-like_C.
DR   InterPro; IPR038610; FliK-like_C_sf.
DR   Pfam; PF02120; Flg_hook; 1.
DR   PRINTS; PR01007; FLGHOOKFLIK.
PE   3: Inferred from homology;
KW   Bacterial flagellum biogenesis; Reference proteome.
FT   CHAIN           1..375
FT                   /note="Flagellar hook-length control protein"
FT                   /id="PRO_0000180908"
FT   REGION          319..363
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        319..344
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   375 AA;  39312 MW;  4C8FCA941FAC7DB3 CRC64;
     MIRLAPLITA DVDTTTLPGG KASDAAQDFL ALLSEALAGE TTTDKAAPQL LVATDKPTTK
     GEPLISDIVS DAQQANLLIP VDETPPVIND EQSTSTPLTT AQTMALAAVA DKNTTKDEKA
     DDLNEDVTAS LSALFAMLPG FDNTPKVTDA PSTVLPTEKP TLFTKLTSEQ LTTAQPDDAP
     GTPAQPLTPL VAEAQSKAEV ISTPSPVTAA ASPLITPHQT QPLPTVAAPV LSAPLGSHEW
     QQSLSQHISL FTRQGQQSAE LRLHPQDLGE VQISLKVDDN QAQIQMVSPH QHVRAALEAA
     LPVLRTQLAE SGIQLGQSNI SGESFSGQQQ AASQQQQSQR TANHEPLAGE DDDTLPVPVS
     LQGRVTGNSG VDIFA