FLIK_SALTY
ID FLIK_SALTY Reviewed; 405 AA.
AC P26416;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Flagellar hook-length control protein;
GN Name=fliK; Synonyms=flaE, flaR; OrderedLocusNames=STM1974;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RX PubMed=8631687; DOI=10.1128/jb.178.10.2954-2959.1996;
RA Kawagishi I., Homma M., Williams A.W., Macnab R.M.;
RT "Characterization of the flagellar hook length control protein fliK of
RT Salmonella typhimurium and Escherichia coli.";
RL J. Bacteriol. 178:2954-2959(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-5.
RX PubMed=1646201; DOI=10.1128/jb.173.11.3564-3572.1991;
RA Vogler A.P., Homma M., Irikura V.M., Macnab R.M.;
RT "Salmonella typhimurium mutants defective in flagellar filament regrowth
RT and sequence similarity of FliI to F0F1, vacuolar, and archaebacterial
RT ATPase subunits.";
RL J. Bacteriol. 173:3564-3572(1991).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 402-405.
RX PubMed=2656645; DOI=10.1128/jb.171.6.3247-3257.1989;
RA Kihara M., Homma M., Kutsukake K., Macnab R.M.;
RT "Flagellar switch of Salmonella typhimurium: gene sequences and deduced
RT protein sequences.";
RL J. Bacteriol. 171:3247-3257(1989).
CC -!- FUNCTION: Controls the length of the flagellar hook.
CC -!- INTERACTION:
CC P26416; P0A1I9: flgD; NbExp=2; IntAct=EBI-6408664, EBI-6408673;
CC P26416; P0A1J1: flgE; NbExp=2; IntAct=EBI-6408664, EBI-6408688;
CC -!- DOMAIN: Two-domain protein with the central portion of the sequence
CC acting as a hinge or connector between the two.
CC -!- SIMILARITY: Belongs to the FliK family. {ECO:0000305}.
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DR EMBL; L43492; AAD15264.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL20886.1; -; Genomic_DNA.
DR EMBL; M62408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M24463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; E42364; E42364.
DR PIR; S78691; S78691.
DR RefSeq; NP_460927.1; NC_003197.2.
DR RefSeq; WP_000631669.1; NC_003197.2.
DR PDB; 2RRL; NMR; -; A=204-370.
DR PDBsum; 2RRL; -.
DR AlphaFoldDB; P26416; -.
DR BMRB; P26416; -.
DR SMR; P26416; -.
DR IntAct; P26416; 2.
DR STRING; 99287.STM1974; -.
DR PaxDb; P26416; -.
DR EnsemblBacteria; AAL20886; AAL20886; STM1974.
DR GeneID; 1253495; -.
DR KEGG; stm:STM1974; -.
DR PATRIC; fig|99287.12.peg.2091; -.
DR HOGENOM; CLU_039492_0_0_6; -.
DR OMA; ATHEHTP; -.
DR PhylomeDB; P26416; -.
DR BioCyc; SENT99287:STM1974-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0009424; C:bacterial-type flagellum hook; IEA:InterPro.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR Gene3D; 3.30.750.140; -; 1.
DR InterPro; IPR001635; Flag_hook_Flik.
DR InterPro; IPR021136; Flagellar_hook_control-like_C.
DR InterPro; IPR038610; FliK-like_C_sf.
DR Pfam; PF02120; Flg_hook; 1.
DR PRINTS; PR01007; FLGHOOKFLIK.
PE 1: Evidence at protein level;
KW 3D-structure; Bacterial flagellum biogenesis; Reference proteome.
FT CHAIN 1..405
FT /note="Flagellar hook-length control protein"
FT /id="PRO_0000180909"
FT REGION 172..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 350..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT STRAND 260..262
FT /evidence="ECO:0007829|PDB:2RRL"
FT HELIX 269..285
FT /evidence="ECO:0007829|PDB:2RRL"
FT STRAND 289..292
FT /evidence="ECO:0007829|PDB:2RRL"
FT HELIX 297..299
FT /evidence="ECO:0007829|PDB:2RRL"
FT STRAND 302..309
FT /evidence="ECO:0007829|PDB:2RRL"
FT STRAND 312..318
FT /evidence="ECO:0007829|PDB:2RRL"
FT HELIX 323..330
FT /evidence="ECO:0007829|PDB:2RRL"
FT HELIX 332..340
FT /evidence="ECO:0007829|PDB:2RRL"
FT TURN 341..343
FT /evidence="ECO:0007829|PDB:2RRL"
FT STRAND 345..354
FT /evidence="ECO:0007829|PDB:2RRL"
SQ SEQUENCE 405 AA; 41795 MW; 256032D33ED7FB7C CRC64;
MITLPQLITT DTDMTAGLTS GKTTGSAEDF LALLAGALGA DGAQGKDARI TLADLQAAGG
KLSKELLTQH GEPGQAVKLA DLLAQKANAT DETLTDLTQA QHLLSTLTPS LKTSALAALS
KTAQHDEKTP ALSDEDLASL SALFAMLPGQ PVATPVAGET PAENHIALPS LLRGDMPSAP
QEETHTLSFS EHEKGKTEAS LARASDDRAT GPALTPLVVA AAATSAKVEV DSPPAPVTHG
AAMPTLSSAT AQPLPVASAP VLSAPLGSHE WQQTFSQQVM LFTRQGQQSA QLRLHPEELG
QVHISLKLDD NQAQLQMVSP HSHVRAALEA ALPMLRTQLA ESGIQLGQSS ISSESFAGQQ
QSSSQQQSSR AQHTDAFGAE DDIALAAPAS LQAAARGNGA VDIFA
