FLIL_CAUVN
ID FLIL_CAUVN Reviewed; 205 AA.
AC B8GXB6; P34008;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Flagellar FliL protein;
GN Name=fliL; OrderedLocusNames=CCNA_02141;
OS Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=565050;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1315735; DOI=10.1128/jb.174.10.3327-3338.1992;
RA Yu J., Shapiro L.;
RT "Early Caulobacter crescentus genes fliL and fliM are required for
RT flagellar gene expression and normal cell division.";
RL J. Bacteriol. 174:3327-3338(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NA1000 / CB15N;
RX PubMed=20472802; DOI=10.1128/jb.00255-10;
RA Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V.,
RA Walunas T.L., Crosson S.;
RT "The genetic basis of laboratory adaptation in Caulobacter crescentus.";
RL J. Bacteriol. 192:3678-3688(2010).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=7932752; DOI=10.1006/jmbi.1994.1650;
RA Jenal U., White J., Shapiro L.;
RT "Caulobacter flagellar function, but not assembly, requires FliL, a non-
RT polarly localized membrane protein present in all cell types.";
RL J. Mol. Biol. 243:227-244(1994).
RN [4]
RP ERRATUM OF PUBMED:7932752.
RA Jenal U., White J., Shapiro L.;
RL J. Mol. Biol. 248:883-883(1995).
CC -!- FUNCTION: Controls the rotational direction of flagella during
CC chemotaxis. {ECO:0000269|PubMed:7932752}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:7932752};
CC Single-pass membrane protein {ECO:0000269|PubMed:7932752}.
CC Note=Distributed throughout the cell inner membrane and not just at the
CC poles;.
CC -!- INDUCTION: Found in all cell types and all developmental stages (at
CC protein level), the transcript is turned off in swarmer cells and
CC turned on in stalked cells. {ECO:0000269|PubMed:7932752}.
CC -!- DISRUPTION PHENOTYPE: Forms a complete but paralyzed flagellum.
CC {ECO:0000269|PubMed:7932752}.
CC -!- SIMILARITY: Belongs to the FliL family. {ECO:0000305}.
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DR EMBL; M85232; AAA62448.1; -; Genomic_DNA.
DR EMBL; CP001340; ACL95606.1; -; Genomic_DNA.
DR RefSeq; WP_012640398.1; NC_011916.1.
DR RefSeq; YP_002517514.1; NC_011916.1.
DR AlphaFoldDB; B8GXB6; -.
DR SMR; B8GXB6; -.
DR PRIDE; B8GXB6; -.
DR EnsemblBacteria; ACL95606; ACL95606; CCNA_02141.
DR GeneID; 7330447; -.
DR KEGG; ccs:CCNA_02141; -.
DR PATRIC; fig|565050.3.peg.2099; -.
DR HOGENOM; CLU_099018_2_1_5; -.
DR OMA; DLLIMEF; -.
DR OrthoDB; 1873899at2; -.
DR Proteomes; UP000001364; Chromosome.
DR GO; GO:0009425; C:bacterial-type flagellum basal body; IEA:InterPro.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0071973; P:bacterial-type flagellum-dependent cell motility; IEA:InterPro.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR InterPro; IPR005503; FliL.
DR PANTHER; PTHR35091; PTHR35091; 1.
DR Pfam; PF03748; FliL; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Chemotaxis; Flagellar rotation;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..205
FT /note="Flagellar FliL protein"
FT /id="PRO_0000395336"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 26..63
FT /note="Not required for flagellum motility, although
FT mutants lcaking this region swim less smoothly and are more
FT sensitive to O(2) deprivation"
FT REGION 58..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 56
FT /note="K -> E (in Ref. 1; AAA62448)"
FT /evidence="ECO:0000305"
FT CONFLICT 92..101
FT /note="GAAGTPVIKE -> RRWDSGDQG (in Ref. 1; AAA62448)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 205 AA; 22108 MW; 4D5352FC7F29DE7C CRC64;
MAKKPEKEAP APEGEEGAEG EAPAKKKPPI LIIAIAAGVL VLGGGGAAAF FLLKPKPAAE
AGEHGEKKEE KKKEKKKEEK GDKKDAEKGA EGAAGTPVIK EGPDGVVFYT LPDIVVNMQT
ADGKSTFLKL KLTFELPDEE TADELTPNLP RLQDMFQTFL RELRPEDLNG SQGTYQLRVE
LLRRVNLVAA PAKVNAVLIE EMLIN
