ID   FLIM_BACSU              Reviewed;         332 AA.
AC   P23453; Q57518;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=Flagellar motor switch protein FliM;
GN   Name=fliM; OrderedLocusNames=BSU16310;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1898932; DOI=10.1128/jb.173.2.710-719.1991;
RA   Zuberi A.R., Bischoff D.S., Ordal G.W.;
RT   "Nucleotide sequence and characterization of a Bacillus subtilis gene
RT   encoding a flagellar switch protein.";
RL   J. Bacteriol. 173:710-719(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-59.
RC   STRAIN=168;
RX   PubMed=1828465; DOI=10.1128/jb.173.11.3573-3579.1991;
RA   Albertini A.M., Caramori T., Crabb W.D., Scoffone F., Galizzi A.;
RT   "The flaA locus of Bacillus subtilis is part of a large operon coding for
RT   flagellar structures, motility functions, and an ATPase-like polypeptide.";
RL   J. Bacteriol. 173:3573-3579(1991).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 309-332.
RX   PubMed=1447979; DOI=10.1111/j.1365-2958.1992.tb01448.x;
RA   Bischoff D.S., Ordal G.W.;
RT   "Identification and characterization of FliY, a novel component of the
RT   Bacillus subtilis flagellar switch complex.";
RL   Mol. Microbiol. 6:2715-2723(1992).
RN   [5]
RP   INTERACTION WITH CHEY.
RC   STRAIN=168 / OI1085;
RX   PubMed=12920116; DOI=10.1074/jbc.m306180200;
RA   Szurmant H., Bunn M.W., Cannistraro V.J., Ordal G.W.;
RT   "Bacillus subtilis hydrolyzes CheY-P at the location of its action, the
RT   flagellar switch.";
RL   J. Biol. Chem. 278:48611-48616(2003).
CC   -!- FUNCTION: One of the proteins that forms a switch complex that is
CC       proposed to be located at the base of the basal body. This complex
CC       interacts with chemotaxis proteins (such as CheY) in addition to
CC       contacting components of the motor that determine the direction of
CC       flagellar rotation.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein.
CC       Bacterial flagellum basal body.
CC   -!- SIMILARITY: Belongs to the FliM family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA39530.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; M37691; AAA22446.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB13504.1; -; Genomic_DNA.
DR   EMBL; X56049; CAA39530.1; ALT_INIT; Genomic_DNA.
DR   EMBL; M86738; AAA22448.1; -; Genomic_DNA.
DR   PIR; B39136; B39136.
DR   RefSeq; NP_389513.1; NC_000964.3.
DR   RefSeq; WP_003220879.1; NZ_JNCM01000035.1.
DR   AlphaFoldDB; P23453; -.
DR   SMR; P23453; -.
DR   STRING; 224308.BSU16310; -.
DR   PaxDb; P23453; -.
DR   PRIDE; P23453; -.
DR   EnsemblBacteria; CAB13504; CAB13504; BSU_16310.
DR   GeneID; 64303524; -.
DR   GeneID; 939518; -.
DR   KEGG; bsu:BSU16310; -.
DR   PATRIC; fig|224308.179.peg.1772; -.
DR   eggNOG; COG1868; Bacteria.
DR   InParanoid; P23453; -.
DR   OMA; NPQFTQI; -.
DR   PhylomeDB; P23453; -.
DR   BioCyc; BSUB:BSU16310-MON; -.
DR   PRO; PR:P23453; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0009425; C:bacterial-type flagellum basal body; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003774; F:cytoskeletal motor activity; IEA:InterPro.
DR   GO; GO:0044780; P:bacterial-type flagellum assembly; IMP:CACAO.
DR   GO; GO:0071978; P:bacterial-type flagellum-dependent swarming motility; IMP:CACAO.
DR   GO; GO:0050918; P:positive chemotaxis; IMP:CACAO.
DR   CDD; cd17908; FliM; 1.
DR   Gene3D; 2.30.330.10; -; 1.
DR   Gene3D; 3.40.1550.10; -; 1.
DR   InterPro; IPR028976; CheC-like_sf.
DR   InterPro; IPR001689; Flag_FliM.
DR   InterPro; IPR001543; FliN-like_C.
DR   InterPro; IPR036429; SpoA-like_sf.
DR   Pfam; PF02154; FliM; 1.
DR   Pfam; PF01052; FliMN_C; 1.
DR   PIRSF; PIRSF002888; FliM; 1.
DR   PRINTS; PR00955; FLGMOTORFLIM.
DR   SUPFAM; SSF101801; SSF101801; 1.
DR   SUPFAM; SSF103039; SSF103039; 1.
DR   TIGRFAMs; TIGR01397; fliM_switch; 1.
PE   1: Evidence at protein level;
KW   Bacterial flagellum; Cell membrane; Chemotaxis; Flagellar rotation;
KW   Membrane; Reference proteome.
FT   CHAIN           1..332
FT                   /note="Flagellar motor switch protein FliM"
FT                   /id="PRO_0000180922"
SQ   SEQUENCE   332 AA;  37529 MW;  5078D0B54E8D08E5 CRC64;
     MSGEVLSQNE IDALLSAIST GEMDAEELKK EEKEKKVKVY DFKRALRFSK DQIRSLTRIH
     DNFARLLTTH FSAQLRTYIH ISVSSVDQVP YEEFIRSIPN MTILNLFDVH PMEGRIMMEV
     NPTIAYTMMD RVMGGIGISH NKVDSLTEIE TKIISNLFEN ALGNYKEAWQ SIADIEPEMT
     EFEVNPQFVQ MVSPNETVVV ISLNTQIGEI SGVINLCIPH IVLEPLIPKL SVHYWMQSDR
     NEPKPEETKS LEKRIMTAQI PVVAELGTSE LTIEEFLSLE VGDCITLDKS VTDPLTVLVG
     DKPKFLGQAG RVNRKQAVQI LDHDIRGEQD GE