ID   FLIM_TREPA              Reviewed;         344 AA.
AC   P74927;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 2.
DT   25-MAY-2022, entry version 121.
DE   RecName: Full=Flagellar motor switch protein FliM;
GN   Name=fliM; OrderedLocusNames=TP_0721;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8755894; DOI=10.1128/jb.178.15.4628-4634.1996;
RA   Limberger R.J., Slivienski L.L., El-Afandi M.C.T., Dantuono L.A.;
RT   "Organization, transcription, and expression of the 5' region of the fla
RT   operon of Treponema phagedenis and Treponema pallidum.";
RL   J. Bacteriol. 178:4628-4634(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 190-344.
RC   STRAIN=Nichols;
RX   PubMed=8529894; DOI=10.1016/0378-1119(95)00583-x;
RA   Hardham J.M., Frye J.G., Stamm L.V.;
RT   "Identification and sequences of the Treponema pallidum fliM', fliY, fliP,
RT   fliQ, fliR and flhB' genes.";
RL   Gene 166:57-64(1995).
CC   -!- FUNCTION: FliM is one of three proteins (FliG, FliN, FliM) that forms
CC       the rotor-mounted switch complex (C ring), located at the base of the
CC       basal body. This complex interacts with the CheY and CheZ chemotaxis
CC       proteins, in addition to contacting components of the motor that
CC       determine the direction of flagellar rotation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}. Bacterial flagellum basal body
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FliM family. {ECO:0000305}.
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DR   EMBL; U28219; AAB61256.1; -; Genomic_DNA.
DR   EMBL; AE000520; AAC65687.1; -; Genomic_DNA.
DR   EMBL; U36839; AAB00543.1; -; Genomic_DNA.
DR   PIR; E71291; E71291.
DR   RefSeq; WP_010882166.1; NC_021490.2.
DR   AlphaFoldDB; P74927; -.
DR   SMR; P74927; -.
DR   IntAct; P74927; 4.
DR   STRING; 243276.TPANIC_0721; -.
DR   EnsemblBacteria; AAC65687; AAC65687; TP_0721.
DR   KEGG; tpa:TP_0721; -.
DR   eggNOG; COG1868; Bacteria.
DR   HOGENOM; CLU_052646_0_0_12; -.
DR   OMA; NPQFTQI; -.
DR   OrthoDB; 1748746at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0009425; C:bacterial-type flagellum basal body; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003774; F:cytoskeletal motor activity; IEA:InterPro.
DR   GO; GO:0071973; P:bacterial-type flagellum-dependent cell motility; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   CDD; cd17908; FliM; 1.
DR   Gene3D; 2.30.330.10; -; 1.
DR   Gene3D; 3.40.1550.10; -; 1.
DR   InterPro; IPR028976; CheC-like_sf.
DR   InterPro; IPR001689; Flag_FliM.
DR   InterPro; IPR001543; FliN-like_C.
DR   InterPro; IPR036429; SpoA-like_sf.
DR   Pfam; PF02154; FliM; 1.
DR   Pfam; PF01052; FliMN_C; 1.
DR   PIRSF; PIRSF002888; FliM; 1.
DR   PRINTS; PR00955; FLGMOTORFLIM.
DR   SUPFAM; SSF101801; SSF101801; 1.
DR   SUPFAM; SSF103039; SSF103039; 1.
DR   TIGRFAMs; TIGR01397; fliM_switch; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum; Cell inner membrane; Cell membrane; Chemotaxis;
KW   Flagellar rotation; Membrane; Reference proteome.
FT   CHAIN           1..344
FT                   /note="Flagellar motor switch protein FliM"
FT                   /id="PRO_0000180932"
SQ   SEQUENCE   344 AA;  38553 MW;  A2AC419677449737 CRC64;
     MTEVLSQDEI DQLLTAISSG DASIEDARPI SDTRKITLYD FRRPDKFSKE QMRTLSLMHE
     TFARLTTTSL SAQLRSMVHV HVASVDQLTY EEFIRSIPTP STLAVITMDP LKGNAVLEVD
     PSITFSIIDR LFGGTGQAAK VQRDLTDIEN SVMEGVIVRI LANVRESWTQ VIDLRPRLGQ
     IETNPQFAQI VPPSEMVVLV TLETKVGEEE GMMNFCIPYI TIEPIISKLS SQFWFSSVRR
     SSTTQYMGVL RDKLSTVDMD VVAEVGSLRL SVRDILGLRV GDIIRLHDTH VGDPFVLSIG
     NRKKFLCQPG VVGKKIAAQI LERIESTSQE DFEELSADEE ELYE