ID   FLIPR_STAA8             Reviewed;         133 AA.
AC   Q2FZC0;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=FPRL1 inhibitory protein;
DE            Short=FLIPr;
DE   Flags: Precursor;
GN   Name=flr; OrderedLocusNames=SAOUHSC_01112;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
CC   -!- FUNCTION: May be involved in countering the first line of host defense
CC       mechanisms. Impairs the leukocyte response to FPRL1 agonists by binding
CC       directly to host FPRL1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CHIPS/FLIPr family. {ECO:0000305}.
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DR   EMBL; CP000253; ABD30226.1; -; Genomic_DNA.
DR   RefSeq; WP_000739563.1; NZ_LS483365.1.
DR   RefSeq; YP_499656.1; NC_007795.1.
DR   AlphaFoldDB; Q2FZC0; -.
DR   STRING; 1280.SAXN108_1151; -.
DR   EnsemblBacteria; ABD30226; ABD30226; SAOUHSC_01112.
DR   GeneID; 3920754; -.
DR   KEGG; sao:SAOUHSC_01112; -.
DR   PATRIC; fig|93061.5.peg.1019; -.
DR   HOGENOM; CLU_157996_0_0_9; -.
DR   OMA; KDDERAT; -.
DR   PRO; PR:Q2FZC0; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.10.20.390; -; 1.
DR   InterPro; IPR023256; FLIPR.
DR   InterPro; IPR038529; FLIPR/CHIP_sf.
DR   InterPro; IPR023253; FLIPR/CHIPS.
DR   Pfam; PF16104; FPRL1_inhibitor; 1.
DR   PRINTS; PR02037; FLIPR.
DR   PRINTS; PR02035; FLIPRCHIPS.
PE   3: Inferred from homology;
KW   Reference proteome; Secreted; Signal; Virulence.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..133
FT                   /note="FPRL1 inhibitory protein"
FT                   /id="PRO_0000286687"
SQ   SEQUENCE   133 AA;  15203 MW;  F8E27331620032B6 CRC64;
     MKKNITKTII ASTVIAAGLL TQTNDAKAFF SYEWKGLEIA KNLADQAKKD DERIDKLMKE
     SDKNLTPYKA ETVNDLYLIV KKLSQGDVKK AVVRIKDGGP RDYYTFDLTR PLEENRKNIK
     VVKNGEIDSI TWY