ID   FLIPR_STAAB             Reviewed;         133 AA.
AC   Q2YXC0;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=FPRL1 inhibitory protein;
DE            Short=FLIPr;
DE   Flags: Precursor;
GN   Name=flr; OrderedLocusNames=SAB1019c;
OS   Staphylococcus aureus (strain bovine RF122 / ET3-1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=273036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=bovine RF122 / ET3-1;
RX   PubMed=17971880; DOI=10.1371/journal.pone.0001120;
RA   Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.;
RT   "Molecular correlates of host specialization in Staphylococcus aureus.";
RL   PLoS ONE 2:E1120-E1120(2007).
CC   -!- FUNCTION: May be involved in countering the first line of host defense
CC       mechanisms. Impairs the leukocyte response to FPRL1 agonists by binding
CC       directly to host FPRL1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CHIPS/FLIPr family. {ECO:0000305}.
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DR   EMBL; AJ938182; CAI80707.1; -; Genomic_DNA.
DR   RefSeq; WP_000739557.1; NC_007622.1.
DR   AlphaFoldDB; Q2YXC0; -.
DR   SMR; Q2YXC0; -.
DR   KEGG; sab:SAB1019c; -.
DR   HOGENOM; CLU_157996_0_0_9; -.
DR   OMA; KDDERAT; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.10.20.390; -; 1.
DR   InterPro; IPR023256; FLIPR.
DR   InterPro; IPR038529; FLIPR/CHIP_sf.
DR   InterPro; IPR023253; FLIPR/CHIPS.
DR   Pfam; PF16104; FPRL1_inhibitor; 1.
DR   PRINTS; PR02037; FLIPR.
DR   PRINTS; PR02035; FLIPRCHIPS.
PE   3: Inferred from homology;
KW   Secreted; Signal; Virulence.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..133
FT                   /note="FPRL1 inhibitory protein"
FT                   /id="PRO_0000286681"
SQ   SEQUENCE   133 AA;  15102 MW;  7F3A29DBD8FB730C CRC64;
     MKKNITKTII ASTVIAAGLL TQTNDAKAFF SYEGKGLEIA KNLADQAKKD DERIDKLMKE
     SDKNQTPYKA ETVNDLYLIV KKLSQGDVKK AVVRIKDGGP RDYYTFDLTR PLEENRKNIK
     VVKNGEIDSI YWD