ID   FLIPR_STAAC             Reviewed;         133 AA.
AC   Q5HGS8;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=FPRL1 inhibitory protein;
DE            Short=FLIPr;
DE   Flags: Precursor;
GN   Name=flr; OrderedLocusNames=SACOL1166;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: May be involved in countering the first line of host defense
CC       mechanisms. Impairs the leukocyte response to FPRL1 agonists by binding
CC       directly to host FPRL1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CHIPS/FLIPr family. {ECO:0000305}.
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DR   EMBL; CP000046; AAW36545.1; -; Genomic_DNA.
DR   RefSeq; WP_000739563.1; NC_002951.2.
DR   AlphaFoldDB; Q5HGS8; -.
DR   EnsemblBacteria; AAW36545; AAW36545; SACOL1166.
DR   KEGG; sac:SACOL1166; -.
DR   HOGENOM; CLU_157996_0_0_9; -.
DR   OMA; KDDERAT; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.10.20.390; -; 1.
DR   InterPro; IPR023256; FLIPR.
DR   InterPro; IPR038529; FLIPR/CHIP_sf.
DR   InterPro; IPR023253; FLIPR/CHIPS.
DR   Pfam; PF16104; FPRL1_inhibitor; 1.
DR   PRINTS; PR02037; FLIPR.
DR   PRINTS; PR02035; FLIPRCHIPS.
PE   3: Inferred from homology;
KW   Secreted; Signal; Virulence.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..133
FT                   /note="FPRL1 inhibitory protein"
FT                   /id="PRO_0000286682"
SQ   SEQUENCE   133 AA;  15203 MW;  F8E27331620032B6 CRC64;
     MKKNITKTII ASTVIAAGLL TQTNDAKAFF SYEWKGLEIA KNLADQAKKD DERIDKLMKE
     SDKNLTPYKA ETVNDLYLIV KKLSQGDVKK AVVRIKDGGP RDYYTFDLTR PLEENRKNIK
     VVKNGEIDSI TWY