ID   FLIPR_STAAE             Reviewed;         133 AA.
AC   A6QG57;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=FPRL1 inhibitory protein;
DE            Short=FLIPr;
DE   Flags: Precursor;
GN   Name=flr; OrderedLocusNames=NWMN_1067;
OS   Staphylococcus aureus (strain Newman).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=426430;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Newman;
RX   PubMed=17951380; DOI=10.1128/jb.01000-07;
RA   Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT   "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT   analysis of staphylococcal genomes: polymorphism and evolution of two major
RT   pathogenicity islands.";
RL   J. Bacteriol. 190:300-310(2008).
RN   [2]
RP   FUNCTION, AND INTERACTION WITH FPRL1.
RX   PubMed=17114475; DOI=10.4049/jimmunol.177.11.8017;
RA   Prat C., Bestebroer J., de Haas C.J.C., van Strijp J.A.G.,
RA   van Kessel K.P.M.;
RT   "A new staphylococcal anti-inflammatory protein that antagonizes the formyl
RT   peptide receptor-like 1.";
RL   J. Immunol. 177:8017-8026(2006).
CC   -!- FUNCTION: May be involved in countering the first line of host defense
CC       mechanisms. Impairs the leukocyte response to FPRL1 agonists by binding
CC       directly to host FPRL1. Exerts, in vitro, anti-inflammatory activity by
CC       inhibiting calcium mobilization and cell migration toward
CC       chemoattractants. {ECO:0000269|PubMed:17114475}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CHIPS/FLIPr family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP009351; BAF67339.1; -; Genomic_DNA.
DR   RefSeq; WP_000739562.1; NZ_CP023390.1.
DR   AlphaFoldDB; A6QG57; -.
DR   EnsemblBacteria; BAF67339; BAF67339; NWMN_1067.
DR   KEGG; sae:NWMN_1067; -.
DR   HOGENOM; CLU_157996_0_0_9; -.
DR   OMA; KDDERAT; -.
DR   Proteomes; UP000006386; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.10.20.390; -; 1.
DR   InterPro; IPR023256; FLIPR.
DR   InterPro; IPR038529; FLIPR/CHIP_sf.
DR   InterPro; IPR023253; FLIPR/CHIPS.
DR   Pfam; PF16104; FPRL1_inhibitor; 1.
DR   PRINTS; PR02037; FLIPR.
DR   PRINTS; PR02035; FLIPRCHIPS.
PE   1: Evidence at protein level;
KW   Secreted; Signal; Virulence.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..133
FT                   /note="FPRL1 inhibitory protein"
FT                   /id="PRO_0000317036"
SQ   SEQUENCE   133 AA;  15261 MW;  F8E273339F2FE2B6 CRC64;
     MKKNITKTII ASTVIAAGLL TQTNDAKAFF SYEWKGLEIA KNLADQAKKD DERIDKLMKE
     SDKNLTPYKA ETVNDLYLIV KKLSQGDVKK AVVRIKDDGP RDYYTFDLTR PLEENRKNIK
     VVKNGEIDSI TWY