FLIPR_STAAM
ID FLIPR_STAAM Reviewed; 133 AA.
AC Q99UV1;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=FPRL1 inhibitory protein;
DE Short=FLIPr;
DE Flags: Precursor;
GN Name=flr; OrderedLocusNames=SAV1156;
OS Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=158878;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mu50 / ATCC 700699;
RX PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA Hiramatsu K.;
RT "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL Lancet 357:1225-1240(2001).
CC -!- FUNCTION: May be involved in countering the first line of host defense
CC mechanisms. Impairs the leukocyte response to FPRL1 agonists by binding
CC directly to host FPRL1 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CHIPS/FLIPr family. {ECO:0000305}.
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DR EMBL; BA000017; BAB57318.1; -; Genomic_DNA.
DR RefSeq; WP_000739564.1; NC_002758.2.
DR AlphaFoldDB; Q99UV1; -.
DR PaxDb; Q99UV1; -.
DR DNASU; 1121132; -.
DR EnsemblBacteria; BAB57318; BAB57318; SAV1156.
DR KEGG; sav:SAV1156; -.
DR HOGENOM; CLU_157996_0_0_9; -.
DR OMA; KDDERAT; -.
DR BioCyc; SAUR158878:SAV_RS06225-MON; -.
DR Proteomes; UP000002481; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 3.10.20.390; -; 1.
DR InterPro; IPR023256; FLIPR.
DR InterPro; IPR038529; FLIPR/CHIP_sf.
DR InterPro; IPR023253; FLIPR/CHIPS.
DR Pfam; PF16104; FPRL1_inhibitor; 1.
DR PRINTS; PR02037; FLIPR.
DR PRINTS; PR02035; FLIPRCHIPS.
PE 3: Inferred from homology;
KW Secreted; Signal; Virulence.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..133
FT /note="FPRL1 inhibitory protein"
FT /id="PRO_0000286684"
SQ SEQUENCE 133 AA; 15216 MW; E91279C1620032B6 CRC64;
MKKNITKTII ASTVIAAGLL TQTNDAKAFF SYEWKGLEIA KNLADQAKKD DERIDKLMKE
SDKNLTPYKA ETVNDLYLIV KKLSQGDVKK AVVRIKDGGP RDYYTFDLTR PLEENRKNIK
VVKNGEIDSI YWD